{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:19:51Z","timestamp":1791285591767,"version":"4.1.0"},"reference-count":179,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"DOI":"10.1093\/humupd\/dml063","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T01:18:32Z","timestamp":1171675112000},"page":"225-238","source":"Crossref","is-referenced-by-count":239,"title":["Impact of folate and homocysteine metabolism on human reproductive health"],"prefix":"10.1093","volume":"13","author":[{"given":"Thierry","family":"Forges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Monnier-Barbarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Alberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Gu\u00e9ant-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Daval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Gu\u00e9ant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,2,16]]},"reference":[{"key":"key\n\t\t\t\t20171011195544_DML063C1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"3","author":"Agarwal","year":"2005","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20171011195544_DML063C2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.urology.2005.07.012","article-title":"What an andrologist\/urologist should know about free radicals and why","volume":"67","author":"Agarwal","year":"2006","journal-title":"Urology"},{"key":"key\n\t\t\t\t20171011195544_DML063C3","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1095\/biolreprod62.5.1427","article-title":"Expression and regulation of the CC-chemokine monocyte chemoattractant protein-1 in rat testicular cells in primary culture","volume":"62","author":"Aubry","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C4","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","article-title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","volume":"11","author":"Austin","year":"2004","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20171011195544_DML063C5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/humrep\/deh069","article-title":"Increased rates of thrombophilia in women with repeated IVF failures","volume":"19","author":"Azem","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S1472-6483(10)61644-6","article-title":"PCOS: a diagnostic challenge","volume":"8","author":"Azziz","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20171011195544_DML063C7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1507\/endocrj.51.601","article-title":"Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia","volume":"51","author":"Bayraktar","year":"2004","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t20171011195544_DML063C8","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/humrep\/deh684","article-title":"Influence of global sperm DNA methylation on IVF results","volume":"20","author":"Benchaib","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0015-0282(16)56225-6","article-title":"Folinic acid in the treatment of human male infertility","volume":"60","author":"Bentivoglio","year":"1993","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4065\/75.1.18","article-title":"The effect of estrogen replacement therapy on total plasma homocysteine in healthy postmenopausal women","volume":"75","author":"Berger","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"key\n\t\t\t\t20171011195544_DML063C11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/bmj.38369.437789.82","article-title":"Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records","volume":"330","author":"Berry","year":"2005","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20171011195544_DML063C12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1297-9589(01)00278-8","article-title":"Evolution of homocysteine during ovarian stimulation for IVF or ICSI","volume":"30","author":"Bettahar-Lebugle","year":"2000","journal-title":"Gynecol Obstet Fertil"},{"key":"key\n\t\t\t\t20171011195544_DML063C13","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1056\/NEJM200104123441517","article-title":"Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility","volume":"344","author":"Bezold","year":"2001","journal-title":"New Engl J Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C14","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1111\/j.1742-4658.2005.04857.x","article-title":"Megalin binds and mediates cellular internalization of folate binding protein","volume":"272","author":"Birn","year":"2005","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20171011195544_DML063C15","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1203\/01.PDR.0000161406.19231.98","article-title":"Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats","volume":"57","author":"Blaise","year":"2005","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t20171011195544_DML063C16","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171011195544_DML063C17","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1172\/JCI111161","article-title":"Unique efficiency of methionine metabolism in premenopausal women may protect against vascular disease in the reproductive years","volume":"72","author":"Boers","year":"1983","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C18","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.aje.a010290","article-title":"5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review","volume":"151","author":"Botto","year":"2000","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t20171011195544_DML063C19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/00365519209088360","article-title":"Plasma homocysteine in women on oral oestrogen-containing contraceptives and in men with oestrogen-treated prostatic carcinoma","volume":"52","author":"Brattstrom","year":"1992","journal-title":"Scand J Clin Lab Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humrep\/deg122","article-title":"Peritoneal fluid concentrations of interleukin-8 in patients with endometriosis depend on the severity of the disorder and are higher in the luteal phase","volume":"18","author":"Calhaz-Jorge","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C21","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1515\/CCLM.2003.157","article-title":"Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss","volume":"41","author":"Candito","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/geno.2000.6319","article-title":"Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes","volume":"70","author":"Chadwick","year":"2000","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20171011195544_DML063C23","first-page":"80","article-title":"Comparison of seminal vitamin B12, folate, reactive oxygen species and various sperm parameters between fertile and infertile males","volume":"30","author":"Chen","year":"2001","journal-title":"Wei Sheng Yan Jiu"},{"key":"key\n\t\t\t\t20171011195544_DML063C24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1096-8628(19990521)84:2<151::AID-AJMG12>3.0.CO;2-T","article-title":"Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects","volume":"84","author":"Christensen","year":"1999","journal-title":"Am J Med Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C26","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1073\/pnas.87.4.1431","article-title":"Pyrimethamine: an approach to the development of a male contraceptive","volume":"87","author":"Cosentino","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171011195544_DML063C27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/humrep\/14.1.211","article-title":"Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion","volume":"14","author":"Coumans","year":"1999","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ajog.2004.02.018","article-title":"Periconceptional folic acid\/multivitamin supplementation and twin pregnancy","volume":"191","author":"Czeizel","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0001566000001938","article-title":"The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causes","volume":"43","author":"Czeizel","year":"1994","journal-title":"Acta Genet Med Gemellol (Roma)"},{"key":"key\n\t\t\t\t20171011195544_DML063C30","first-page":"379","article-title":"Recurrent spontaneous miscarriages and hyperhomocysteinemia","volume":"56","author":"Del Bianco","year":"2004","journal-title":"Minerva Ginecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/abbi.2001.2474","article-title":"Immunohistochemical detection of betaine-homocysteine S-methyltransferase in human, pig, and rat liver and kidney","volume":"393","author":"Delgado-Reyes","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20171011195544_DML063C32","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1095\/biolreprod.103.015800","article-title":"Homocysteine induces trophoblast cell death with apoptotic features","volume":"69","author":"Di Simone","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/humrep\/del396","article-title":"Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF","volume":"22","author":"Dobson","year":"2007","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C34","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1210\/endo.141.9.7661","article-title":"Deoxyribonucleic acid hypomethylation of male germ cells by mitotic and meiotic exposure to 5-azacytidine is associated with altered testicular histology","volume":"141","author":"Doerksen","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20171011195544_DML063C35","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0015-0282(03)02157-5","article-title":"C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration","volume":"80","author":"Ebisch","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C36","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/humrep\/del081","article-title":"Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple","volume":"21","author":"Ebisch","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2605.2005.00598.x","article-title":"Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?","volume":"29","author":"Ebisch","year":"2006","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20171011195544_DML063C38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1375\/1369052012155","article-title":"Use of multivitamins and folic acid in early pregnancy and multiple births in Sweden","volume":"4","author":"Ericson","year":"2001","journal-title":"Twin Res"},{"key":"key\n\t\t\t\t20171011195544_DML063C39","first-page":"157","article-title":"Homocysteine and human reproduction","volume":"27","author":"Eskes","year":"2000","journal-title":"Clin Exp Obstet Gynecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0015-0282(02)04676-9","article-title":"Effects of estrogen and psychological stress on plasma homocysteine levels","volume":"79","author":"Farag","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C41","first-page":"19","article-title":"Zinc deficiency and dietary folate metabolism in pregnant rats","volume":"7","author":"Favier","year":"1993","journal-title":"J Trace Elem Electrolytes Health Dis"},{"key":"key\n\t\t\t\t20171011195544_DML063C42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0027-5107(01)00079-3","article-title":"The role of folic acid and Vitamin B12 in genomic stability of human cells","volume":"475","author":"Fenech","year":"2001","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20171011195544_DML063C43","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1046\/j.1523-1755.2001.59780221.x","article-title":"The folate cycle and disease in humans","volume":"59","author":"Fowler","year":"2001","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20171011195544_DML063C44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-2005-872394","article-title":"Homocysteine: overview of biochemistry, molecular biology, and role in disease processes","volume":"5","author":"Fowler","year":"2005","journal-title":"Semin Vasc Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C45","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.062066299","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status","volume":"99","author":"Friso","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171011195544_DML063C46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C47","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1001\/jama.288.15.1867","article-title":"Plasma folate levels and risk of spontaneous abortion","volume":"288","author":"George","year":"2002","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171011195544_DML063C48","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejogrb.2005.03.019","article-title":"Evaluation of monocyte chemotactic protein-1 levels in peripheral blood of infertile women with endometriosis","volume":"122","author":"Gmyrek","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171011195544_DML063C49","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1182\/blood-2003-01-0320","article-title":"Antiphospholipid\/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study","volume":"102","author":"Gris","year":"2003","journal-title":"Blood"},{"key":"key\n\t\t\t\t20171011195544_DML063C50","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1055\/s-0037-1614292","article-title":"Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss","volume":"92","author":"Gueant","year":"2004","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t20171011195544_DML063C51","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1515\/CCLM.2003.226","article-title":"Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?","volume":"41","author":"Gueant","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C52","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/ajcn.83.3.701","article-title":"Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations","volume":"83","author":"Gueant-Rodriguez","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C53","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(06)68651-0","article-title":"Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study","volume":"367","author":"Haggarty","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C54","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1521-6934(03)00009-9","article-title":"Homocysteine and pregnancy","volume":"17","author":"Hague","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C55","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0021-9150(99)00321-4","article-title":"Increased plasma homocysteine after menopause","volume":"149","author":"Hak","year":"2000","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20171011195544_DML063C56","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(03)14237-7","article-title":"Twinning","volume":"362","author":"Hall","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C57","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/qjmed\/89.8.571","article-title":"The common \u2018thermolabile\u2019 variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia","volume":"89","author":"Harmon","year":"1996","journal-title":"QJM"},{"key":"key\n\t\t\t\t20171011195544_DML063C58","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/humrep\/15.12.2659","article-title":"The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C\u2013 > T mutation","volume":"15","author":"Hasbargen","year":"2000","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s004330050087","article-title":"Vitamin supplementation during weight reduction \u2013 favourable effect on homocysteine metabolism","volume":"198","author":"Henning","year":"1998","journal-title":"Res Exp Med (Berl)"},{"key":"key\n\t\t\t\t20171011195544_DML063C60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2174\/1381612033391720","article-title":"Nitric oxide is a signaling molecule in spermatozoa","volume":"9","author":"Herrero","year":"2003","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20171011195544_DML063C61","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1515\/CCLM.2001.110","article-title":"The importance of hyperhomocysteinemia as a risk factor for diseases: an overview","volume":"39","author":"Herrmann","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C62","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF01127499","article-title":"A high-affinity folate binding protein in human semen","volume":"11","author":"Holm","year":"1991","journal-title":"Biosci Rep"},{"key":"key\n\t\t\t\t20171011195544_DML063C63","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1023\/A:1020219029206","article-title":"Characterization of a high-affinity folate receptor in normal and malignant human testicular tissue","volume":"19","author":"Holm","year":"1999","journal-title":"Biosci Rep"},{"key":"key\n\t\t\t\t20171011195544_DML063C64","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/humupd\/dmi001","article-title":"Apoptosis in the ovary: molecular mechanisms","volume":"11","author":"Hussein","year":"2005","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171011195544_DML063C65","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1086\/303082","article-title":"Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations","volume":"67","author":"Isotalo","year":"2000","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171011195544_DML063C67","first-page":"949","article-title":"Homocysteine level in ovarian follicular fluid or serum as a predictor of successful fertilization","volume":"74","author":"Jerzak","year":"2003","journal-title":"Ginekol Pol"},{"key":"key\n\t\t\t\t20171011195544_DML063C68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s004330050054","article-title":"Regulation of male fertility by pyrimethamine in adult mice","volume":"197","author":"Kalla","year":"1997","journal-title":"Res Exp Med (Berl)"},{"key":"key\n\t\t\t\t20171011195544_DML063C69","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.earlhumdev.2004.06.002","article-title":"Use of folic acid supplementation and risk for dizygotic twinning","volume":"80","author":"Kallen","year":"2004","journal-title":"Early Hum Dev"},{"key":"key\n\t\t\t\t20171011195544_DML063C70","first-page":"328","article-title":"Homocysteinemia and ovariectomy \u2013 initial experience with functional monitoring","volume":"67","author":"Kapral","year":"2002","journal-title":"Ceska Gyneko"},{"key":"key\n\t\t\t\t20171011195544_DML063C71","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI0216886","article-title":"Orchestrating the unfolded protein response in health and disease","volume":"110","author":"Kaufman","year":"2002","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C72","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/j.1939-4640.2003.tb03133.x","article-title":"5-aza-2\u2032-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome","volume":"24","author":"Kelly","year":"2003","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20171011195544_DML063C73","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1095\/biolreprod.104.035238","article-title":"Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation","volume":"72","author":"Kelly","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C74","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/humrep\/deh825","article-title":"Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial","volume":"20","author":"Kilicdag","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C75","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/humrep\/deh700","article-title":"Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study","volume":"20","author":"Kilicdag","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C76","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1507\/endocrj.51.505","article-title":"Relationship between homocysteine and insulin resistance in women with polycystic ovary syndrome","volume":"51","author":"Kilic-Okman","year":"2004","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t20171011195544_DML063C77","first-page":"707","article-title":"Trends in twinning rates in metropolitan Atlanta before and after folic acid fortification","volume":"49","author":"Kucik","year":"2004","journal-title":"J Reprod Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C78","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/BF01981432","article-title":"Folic acid levels in blood and seminal plasma of normo- and oligospermic patients prior and following folic acid treatment","volume":"34","author":"Landau","year":"1978","journal-title":"Experientia"},{"key":"key\n\t\t\t\t20171011195544_DML063C79","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/humupd\/4.2.177","article-title":"The vanishing twin: a review","volume":"4","author":"Landy","year":"1998","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171011195544_DML063C80","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/dvdy.20527","article-title":"Homocysteine inhibits extra-embryonic vascular development in the avian embryo","volume":"234","author":"Latacha","year":"2005","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20171011195544_DML063C81","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0009-9120(03)00062-6","article-title":"Hyperhomocysteinemia and its role in the development of atherosclerosis","volume":"36","author":"Lawrence de Koning","year":"2003","journal-title":"Clin Biochem"},{"key":"key\n\t\t\t\t20171011195544_DML063C82","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/bdra.20088","article-title":"Food fortification with folic acid and rate of multiple births, 1994\u20132000","volume":"70","author":"Lawrence","year":"2004","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"key\n\t\t\t\t20171011195544_DML063C83","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1095\/biolreprod.103.021329","article-title":"Nitric oxide\/nitric oxide synthase, spermatogenesis, and tight junction dynamics","volume":"70","author":"Lee","year":"2004","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C84","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1074\/jbc.M411224200","article-title":"Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S -nitrosohomocysteine","volume":"280","author":"Lee","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171011195544_DML063C85","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1016502408305","article-title":"Reproductive fitness in maternal homocystinuria due to cystathionine beta-synthase deficiency","volume":"25","author":"Levy","year":"2002","journal-title":"J Inherit Metab Dis"},{"key":"key\n\t\t\t\t20171011195544_DML063C86","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00441-005-1097-5","article-title":"DNA damage to spermatozoa has impacts on fertilization and pregnancy","volume":"322","author":"Lewis","year":"2005","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20171011195544_DML063C87","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(03)12390-2","article-title":"Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study","volume":"361","author":"Li","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C88","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/ajcn\/28.4.346","article-title":"Oral contraceptive hormones, folate metabolism, and the cervical epithelium","volume":"28","author":"Lindenbaum","year":"1975","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C89","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000058367","article-title":"The plasma homocysteine levels are increased in polycystic ovary syndrome","volume":"53","author":"Loverro","year":"2002","journal-title":"Gynecol Obstet Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C90","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","article-title":"Folic acid: nutritional biochemistry, molecular biology, and role in disease processes","volume":"71","author":"Lucock","year":"2000","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t20171011195544_DML063C91","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.thromres.2003.11.007","article-title":"Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users","volume":"112","author":"Lussana","year":"2003","journal-title":"Thromb Res"},{"key":"key\n\t\t\t\t20171011195544_DML063C92","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/j.1939-4640.1995.tb01750.x","article-title":"The contraceptive effects of etoprine on male mice and rats","volume":"16","author":"Malik","year":"1995","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20171011195544_DML063C93","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2605.2005.00543.x","article-title":"A minor fraction of a high-affinity folate binding protein from the epididymis is associated with membranous vesicles and spermatozoa in human semen","volume":"28","author":"Malm","year":"2005","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20171011195544_DML063C94","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1634\/stemcells.19-4-287","article-title":"Imprinting in the germ line","volume":"19","author":"Mann","year":"2001","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20171011195544_DML063C95","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(04)16256-9","article-title":"Genomic imprinting in disruptive spermatogenesis","volume":"363","author":"Marques","year":"2004","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C96","first-page":"789","article-title":"Embryo implantation after assisted reproductive procedures and maternal thrombophilia","volume":"88","author":"Martinelli","year":"2003","journal-title":"Haematologica"},{"key":"key\n\t\t\t\t20171011195544_DML063C97","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/1381612033391784","article-title":"Nitric oxide and its role during pregnancy: from ovulation to delivery","volume":"9","author":"Maul","year":"2003","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20171011195544_DML063C98","first-page":"A229","article-title":"Folate levels and the effects of folate deficiency in the reproductive organs of male rats","volume":"13","author":"Mayr","year":"1999","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20171011195544_DML063C99","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1053\/meta.2002.34038","article-title":"Effects of two oral contraceptives on plasma levels of nitric oxide, homocysteine, and lipid metabolism","volume":"51","author":"Merki-Feld","year":"2002","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20171011195544_DML063C100","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1515\/CCLM.2001.127","article-title":"Homocysteine in postmenopausal women and the importance of hormone replacement therapy","volume":"39","author":"Mijatovic","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C101","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1095\/biolreprod33.4.902","article-title":"Phospholipid methylation by intact rat Leydig cells","volume":"33","author":"Moger","year":"1985","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C102","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1093\/jn\/112.8.1565","article-title":"Effect of folate deficiency on the reproductive organs of female rhesus monkeys: a cytomorphological and cytokinetic study","volume":"112","author":"Mohanty","year":"1982","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C103","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/humrep\/deg441","article-title":"Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes","volume":"18","author":"Montgomery","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C104","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0028-2243(92)90246-U","article-title":"Disturbed reproductive performance in extreme folic acid deficient golden hamsters","volume":"43","author":"Mooij","year":"1992","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171011195544_DML063C105","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1056\/NEJM198509193131210","article-title":"Vascular disease and homocysteine metabolism","volume":"313","author":"Mudd","year":"1985","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C106","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0140-6736(05)79761-0","article-title":"Genetic selection and folate intake during pregnancy","volume":"352","author":"Munoz-Moran","year":"1998","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C107","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1182\/blood.V97.4.1092","article-title":"Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood","volume":"97","author":"Namour","year":"2001","journal-title":"Blood"},{"key":"key\n\t\t\t\t20171011195544_DML063C108","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1515\/CCLM.2001.126","article-title":"Hyperhomocysteinaemia and human reproduction","volume":"39","author":"Nelen","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C109","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0015-0282(00)01595-8","article-title":"Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis","volume":"74","author":"Nelen","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C110","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1210\/jc.2002-021142","article-title":"Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate reductase in women with polycystic ovary syndrome","volume":"88","author":"Orio","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171011195544_DML063C111","first-page":"712","article-title":"Changes in folate status in overweight\/obese women following two different weight control programmes based on an increased consumption of vegetables or fortified breakfast cereals","volume":"96","author":"Ortega","year":"2006","journal-title":"Br J Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C112","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood.V94.3.959.415k20_959_967","article-title":"Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells","volume":"94","author":"Outinen","year":"1999","journal-title":"Blood"},{"key":"key\n\t\t\t\t20171011195544_DML063C113","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0022-4731(87)90035-5","article-title":"Effects of the transmethylation inhibitor S -adenosyl-homocysteine and of the methyl donor S -adenosyl-methionine on rat Leydig cell function in vitro","volume":"26","author":"Papadopoulos","year":"1987","journal-title":"J Steroid Biochem"},{"key":"key\n\t\t\t\t20171011195544_DML063C114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/13547500500442050","article-title":"MTHFR C677T polymorphism, GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction?","volume":"11","author":"Paracchini","year":"2006","journal-title":"Biomarkers"},{"key":"key\n\t\t\t\t20171011195544_DML063C115","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10815-005-6795-0","article-title":"MTHFR C677T polymorphism associates with unexplained infertile male factors","volume":"22","author":"Park","year":"2005","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C116","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0399-8320(04)95015-4","article-title":"Folate metabolism and colorectal carcinogenesis","volume":"28","author":"Peyrin-Biroulet","year":"2004","journal-title":"Gastroenterol Clin Biol"},{"key":"key\n\t\t\t\t20171011195544_DML063C117","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1161\/01.CIR.103.22.2717","article-title":"Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease","volume":"103","author":"Poddar","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171011195544_DML063C118","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"van der Put","year":"1998","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C119","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0015-0282(97)00451-2","article-title":"A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages","volume":"69","author":"Quere","year":"1998","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0015-0282(01)01678-8","article-title":"Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia","volume":"75","author":"Quere","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C121","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/mrd.1080420304","article-title":"5-Aza deoxycytidine-induced inhibition of differentiation of spermatogonia into spermatocytes in the mouse","volume":"42","author":"Raman","year":"1995","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171011195544_DML063C122","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome","volume":"2","author":"Reik","year":"2001","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C123","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(03)12771-7","article-title":"Thrombophilic disorders and fetal loss: a meta-analysis","volume":"361","author":"Rey","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C124","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/molehr\/8.10.952","article-title":"Implications on human fertility of the 677C\u2013 > T and 1298A\u2013 > C polymorphisms of the MTHFR gene: consequences of a possible genetic selection","volume":"8","author":"Reyes-Engel","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.atherosclerosis.2004.05.014","article-title":"Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults","volume":"176","author":"Romerio","year":"2004","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20171011195544_DML063C126","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/01443610500378764","article-title":"Homocysteine in assisted reproduction: does oestradiol influence homocysteine levels?","volume":"26","author":"Roopnarinesingh","year":"2006","journal-title":"J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C127","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.fertnstert.2004.02.086","article-title":"A genetic polymorphism and male fertility","volume":"81","author":"Rossato","year":"2004","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C128","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/4.1.3","article-title":"Role of nitric oxide in the biology, physiology and pathophysiology of reproduction","volume":"4","author":"Rosselli","year":"1998","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171011195544_DML063C129","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.gene.2004.12.004","article-title":"Establishment of male-specific epigenetic information","volume":"345","author":"Rousseaux","year":"2005","journal-title":"Gene"},{"key":"key\n\t\t\t\t20171011195544_DML063C130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/humupd\/dmh003","article-title":"Role of caspases in male infertility","volume":"10","author":"Said","year":"2004","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171011195544_DML063C131","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/j.1939-4640.2003.tb02693.x","article-title":"Male genital tract inflammation: the role of selected interleukins in regulation of pro-oxidant and antioxidant enzymatic substances in seminal plasma","volume":"24","author":"Sanocka","year":"2003","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20171011195544_DML063C132","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/humrep\/deg190","article-title":"Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine","volume":"18","author":"Schachter","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C133","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00043798-199808000-00003","article-title":"Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry","volume":"5","author":"Scott","year":"1998","journal-title":"J Cardiovasc Risk"},{"key":"key\n\t\t\t\t20171011195544_DML063C134","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/01.AOG.0000154886.40318.5e","article-title":"Effects of folic acid fortification on twin gestation rates","volume":"105","author":"Signore","year":"2005","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1447-0756.2001.tb01241.x","article-title":"Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility","volume":"27","author":"Sills","year":"2001","journal-title":"J Obstet Gynaecol Res"},{"key":"key\n\t\t\t\t20171011195544_DML063C136","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2605.2004.00513.x","article-title":"Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population","volume":"28","author":"Singh","year":"2005","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20171011195544_DML063C137","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2165\/00024677-200504050-00002","article-title":"Management of infertility in women with polycystic ovary syndrome: a practical guide","volume":"4","author":"Stadtmauer","year":"2005","journal-title":"Treat Endocrinol"},{"key":"key\n\t\t\t\t20171011195544_DML063C138","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI112442","article-title":"Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine","volume":"77","author":"Starkebaum","year":"1986","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C139","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/0140-6736(92)90725-I","article-title":"Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae","volume":"339","author":"Steegers-Theunissen","year":"1992","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171011195544_DML063C140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0010-7824(92)90047-W","article-title":"Effects of sub-50 oral contraceptives on homocysteine metabolism: a preliminary study","volume":"45","author":"Steegers-Theunissen","year":"1992","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20171011195544_DML063C141","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0015-0282(16)56401-2","article-title":"Study on the presence of homocysteine in ovarian follicular fluid","volume":"60","author":"Steegers-Theunissen","year":"1993","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C142","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/j.1471-0528.2000.tb11677.x","article-title":"Folate affects apoptosis in human trophoblastic cells","volume":"107","author":"Steegers-Theunissen","year":"2000","journal-title":"BJOG"},{"key":"key\n\t\t\t\t20171011195544_DML063C143","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/01.AOG.0000129955.47943.2a","article-title":"Hyperhomocysteinemia, pregnancy complications, and the timing of investigation","volume":"104","author":"Steegers-Theunissen","year":"2004","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171011195544_DML063C144","first-page":"849","article-title":"Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene","volume":"9","author":"Stern","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t20171011195544_DML063C145","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/01.CIR.0000085067.55901.89","article-title":"Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine","volume":"108","author":"Stuhlinger","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171011195544_DML063C146","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/BF03347018","article-title":"The methylenetethrahydrofolate reductase (MTHFR) C677T polymorphism and male infertility in Italy","volume":"26","author":"Stuppia","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C147","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.HYP.0000127914.94292.76","article-title":"Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways","volume":"43","author":"Suhara","year":"2004","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20171011195544_DML063C148","first-page":"1392","article-title":"Effect of homocysteine concentration in follicular fluid on a degree of oocyte maturity","volume":"74","author":"Szymanski","year":"2003","journal-title":"Ginekol Pol"},{"key":"key\n\t\t\t\t20171011195544_DML063C149","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1046\/j.1365-2362.1999.00572.x","article-title":"Changes of plasma total homocysteine levels during the menstrual cycle","volume":"29","author":"Tallova","year":"1999","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C150","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/jn\/121.7.1042","article-title":"The absorption of pteroylpolyglutamate and intestinal pteroylpolygammaglutamyl hydrolase activity in zinc-deficient rats","volume":"121","author":"Tamura","year":"1991","journal-title":"J Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C151","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/83.5.993","article-title":"Folate and human reproduction","volume":"83","author":"Tamura","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C152","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2174\/1381612033391748","article-title":"Nitric oxide in oocyte maturation, ovulation, fertilization, cleavage and implantation: a little dab'll do ya","volume":"9","author":"Thaler","year":"2003","journal-title":"Curr Pharm Des"},{"key":"key\n\t\t\t\t20171011195544_DML063C153","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1600-0897.2005.00357.x","article-title":"Effects of the common 677 C > T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness to recombinant follicle-stimulating hormone","volume":"55","author":"Thaler","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171011195544_DML063C154","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/humrep\/17.2.314","article-title":"Polycystic ovarian syndrome and thrombophilia","volume":"17","author":"Tsanadis","year":"2002","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-6147(00)01675-8","article-title":"Biological and clinical implications of the MTHFR C677T polymorphism","volume":"22","author":"Ueland","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"key\n\t\t\t\t20171011195544_DML063C156","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2005.01.007","article-title":"Promoter-2-derived Cyp19 expression in bovine granulosa cells coincides with gene-specific DNA hypo-methylation","volume":"233","author":"Vanselow","year":"2005","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20171011195544_DML063C157","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sj.ejcn.1601362","article-title":"Effects of an 8-week weight-loss program on cardiovascular disease risk factors and regional body composition","volume":"56","author":"Volek","year":"2002","journal-title":"Eur J Clin Nutr"},{"key":"key\n\t\t\t\t20171011195544_DML063C158","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.ede.0000152914.84962.13","article-title":"Folate supplementation and twin pregnancies","volume":"16","author":"Vollset","year":"2005","journal-title":"Epidemiology"},{"key":"key\n\t\t\t\t20171011195544_DML063C159","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-2002-23489","article-title":"Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome","volume":"110","author":"Vrbikova","year":"2002","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t20171011195544_DML063C160","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1515\/CCLM.2003.035","article-title":"Plasma thiols and androgen levels in polycystic ovary syndrome","volume":"41","author":"Vrbikova","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C161","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1046\/j.1365-3016.2003.00511.x","article-title":"Rates of twinning before and after fortification of foods in the US with folic acid, Texas, 1996 to 1998","volume":"17","author":"Waller","year":"2003","journal-title":"Paediatr Perinat Epidemiol"},{"key":"key\n\t\t\t\t20171011195544_DML063C162","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0015-0282(00)01697-6","article-title":"Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers","volume":"75","author":"Wallock","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C163","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1389200052997357","article-title":"Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function","volume":"6","author":"Weiss","year":"2005","journal-title":"Curr Drug Metab"},{"key":"key\n\t\t\t\t20171011195544_DML063C164","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/(SICI)1096-8628(19970711)71:1<93::AID-AJMG17>3.0.CO;2-Q","article-title":"Multivitamin supplementation and multiple births","volume":"71","author":"Werler","year":"1997","journal-title":"Am J Med Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C165","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1365-2265.2004.02019.x","article-title":"Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity?","volume":"60","author":"Wijeyaratne","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171011195544_DML063C166","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1677\/joe.0.0410439","article-title":"The effect of folic acid on superovulation in the immature rat","volume":"41","author":"Willmott","year":"1968","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20171011195544_DML063C167","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0015-0282(99)00551-8","article-title":"Male factor subfertility: possible causes and the impact of nutritional factors","volume":"73","author":"Wong","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C168","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0015-0282(01)03229-0","article-title":"Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial","volume":"77","author":"Wong","year":"2002","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C169","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0015-0282(16)56282-7","article-title":"Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss","volume":"60","author":"Wouters","year":"1993","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C170","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2362.1995.tb01687.x","article-title":"Plasma homocysteine and menopausal status","volume":"25","author":"Wouters","year":"1995","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C171","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1365-2796.2003.01213.x","article-title":"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial","volume":"254","author":"Wulffele","year":"2003","journal-title":"J Intern Med"},{"key":"key\n\t\t\t\t20171011195544_DML063C172","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171011195544_DML063C173","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(01)01937-9","article-title":"Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome","volume":"76","author":"Yarali","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171011195544_DML063C174","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/09513590400027265","article-title":"Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome","volume":"20","author":"Yilmaz","year":"2005","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171011195544_DML063C175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1477-7827-2-7","article-title":"Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications","volume":"2","author":"Zetterberg","year":"2004","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20171011195544_DML063C176","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.ejhg.5200767","article-title":"Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos","volume":"10","author":"Zetterberg","year":"2002","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t20171011195544_DML063C177","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/humrep\/deg375","article-title":"Gene\u2013gene interaction between fetal MTHFR 677 C > T and transcobalamin 776 C > G polymorphisms in human spontaneous abortion","volume":"18","author":"Zetterberg","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171011195544_DML063C178","doi-asserted-by":"crossref","first-page":"F671","DOI":"10.1152\/ajprenal.2000.279.4.F671","article-title":"Effects of homocysteine on endothelial nitric oxide production","volume":"279","author":"Zhang","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"key\n\t\t\t\t20171011195544_DML063C179","doi-asserted-by":"crossref","first-page":"35867","DOI":"10.1074\/jbc.M100747200","article-title":"Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response","volume":"276","author":"Zhang","year":"2001","journal-title":"J Biol Chem"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/13\/3\/225\/7421420\/dml063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:43:43Z","timestamp":1707612223000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humupd\/article\/13\/3\/225\/2458410\/Impact-of-folate-and-homocysteine-metabolism-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,16]]},"references-count":179,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,2,16]]},"published-print":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dml063","relation":{},"ISSN":["1460-2369","1355-4786"],"issn-type":[{"value":"1460-2369","type":"electronic"},{"value":"1355-4786","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,5]]},"published":{"date-parts":[[2007,2,16]]}}}