{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:16:47Z","timestamp":1788250607715,"version":"build-2803163510"},"reference-count":172,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"DOI":"10.1093\/humupd\/dmr025","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:14:03Z","timestamp":1306887243000},"page":"741-760","source":"Crossref","is-referenced-by-count":188,"title":["Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome"],"prefix":"10.1093","volume":"17","author":[{"given":"Konstantinos A.","family":"Toulis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios G.","family":"Goulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesthimani","family":"Mintziori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Kintiraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Eukarpidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia-Anastasia","family":"Mouratoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antigoni","family":"Pavlaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Stergianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Poulasouchidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thrasivoulos G.","family":"Tzellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Makedos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chourdakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil C.","family":"Tarlatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,30]]},"reference":[{"key":"key\n\t\t\t\t20171013030021_DMR025C1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejogrb.2004.07.024","article-title":"Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow","volume":"118","author":"Abd El Aal","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/13.3.651","article-title":"Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries","volume":"13","author":"Agrawal","year":"1998","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/bmj.313.7066.1200","article-title":"Detecting skewness from summary information","volume":"313","author":"Altman","year":"1996","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20171013030021_DMR025C4","doi-asserted-by":"crossref","first-page":"e5606","DOI":"10.1371\/journal.pone.0005606","article-title":"Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women","volume":"4","author":"Alvarez-Blasco","year":"2009","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20171013030021_DMR025C5","first-page":"1177","article-title":"Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles","volume":"101","author":"Amato","year":"2003","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/1479164110366053","article-title":"Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus","volume":"7","author":"Anderssohn","year":"2010","journal-title":"Diab Vasc Dis Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.fertnstert.2007.11.057","article-title":"The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function","volume":"91","author":"Arikan","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/09513590903247816","article-title":"Serum resistin and adiponectin levels in young non-obese women with polycystic ovary syndrome","volume":"26","author":"Arikan","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/09513590600906607","article-title":"Vascular endothelial growth factor and basic fibroblast growth factor in polycystic ovary syndrome during controlled ovarian hyperstimulation","volume":"22","author":"Artini","year":"2006","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/14647270802621358","article-title":"Vascular endothelial growth factor and its soluble receptor in patients with polycystic ovary syndrome undergoing IVF","volume":"12","author":"Artini","year":"2009","journal-title":"Hum Fertil (Camb)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/147323000803600113","article-title":"Serum levels of leptin and homocysteine in women with polycystic ovary syndrome and its relationship to endocrine, clinical and metabolic parameters","volume":"36","author":"Atamer","year":"2008","journal-title":"J Int Med Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0015-0282(97)00486-X","article-title":"The plasminogen activator system in women with polycystic ovary syndrome","volume":"69","author":"Atiomo","year":"1998","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2265.2000.00946.x","article-title":"Raised plasminogen activator inhibitor-1 (PAI-1) is not an independent risk factor in the polycystic ovary syndrome (PCOS)","volume":"52","author":"Atiomo","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C14","first-page":"283","article-title":"Serum C-reactive protein (CRP) levels and insulin resistance in non-obese women with polycystic ovarian syndrome, and effect of bicalutamide on hirsutism, CRP levels and insulin resistance","volume":"62","author":"Bahceci","year":"2004","journal-title":"Horm Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C15","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.fertnstert.2006.11.031","article-title":"Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome","volume":"87","author":"Bahceci","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C16","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.fertnstert.2006.12.055","article-title":"Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity","volume":"88","author":"Baillargeon","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C17","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1007\/s00125-007-0831-9","article-title":"Brothers of women with polycystic ovary syndrome are characterised by impaired glucose tolerance, reduced insulin sensitivity and related metabolic defects","volume":"50","author":"Baillargeon","year":"2007","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20171013030021_DMR025C18","first-page":"267","article-title":"Increased serum neopterin levels in women with polycystic ovary syndrome","volume":"36","author":"Barutcuoglu","year":"2006","journal-title":"Ann Clin Lab Sci"},{"key":"key\n\t\t\t\t20171013030021_DMR025C19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/01.AOG.0000296657.41236.10","article-title":"Vascular risk in young women with polycystic ovary and polycystic ovary syndrome","volume":"111","author":"Battaglia","year":"2008","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1507\/endocrj.51.601","article-title":"Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia","volume":"51","author":"Bayraktar","year":"2004","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t20171013030021_DMR025C21","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.2337\/dc06-2142","article-title":"Endothelial function varies according to insulin resistance disease type","volume":"30","author":"Beckman","year":"2007","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20171013030021_DMR025C22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbi.2007.07.003","article-title":"Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome","volume":"22","author":"Benson","year":"2008","journal-title":"Brain Behav Immun"},{"key":"key\n\t\t\t\t20171013030021_DMR025C23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.psyneuen.2008.12.001","article-title":"Disturbed stress responses in women with polycystic ovary syndrome","volume":"34","author":"Benson","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"key\n\t\t\t\t20171013030021_DMR025C24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1742-1241.2008.01897.x","article-title":"Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome","volume":"63","author":"Berneis","year":"2009","journal-title":"Int J Clin Pract"},{"key":"key\n\t\t\t\t20171013030021_DMR025C25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/jcp.2003.015271","article-title":"Cardiovascular risk in women with polycystic ovarian syndrome (PCOS)","volume":"58","author":"Bickerton","year":"2005","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C26","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1210\/jc.2003-031096","article-title":"Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular disease","volume":"89","author":"Boulman","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C27","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1471-0528.2006.01090.x","article-title":"Flow-mediated dilatation in overweight and obese women with polycystic ovary syndrome","volume":"113","author":"Brinkworth","year":"2006","journal-title":"BJOG"},{"key":"key\n\t\t\t\t20171013030021_DMR025C28","first-page":"428","article-title":"Serum levels of resistin and hsCRP in women with PCOS","volume":"4","author":"Capoglu","year":"2009","journal-title":"Cent Eur J Med"},{"key":"key\n\t\t\t\t20171013030021_DMR025C29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.thromres.2004.11.026","article-title":"Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome","volume":"116","author":"Carmassi","year":"2005","journal-title":"Thromb Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C30","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/jc.2004-2279","article-title":"Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters","volume":"90","author":"Carmina","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C31","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1210\/jc.2006-0399","article-title":"Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome","volume":"91","author":"Cascella","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/humrep\/dem356","article-title":"Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome","volume":"23","author":"Cascella","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10815-008-9280-8","article-title":"Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey","volume":"26","author":"Cetinkalp","year":"2009","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C34","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.atherosclerosis.2007.03.002","article-title":"The administration of estrogens, combined with anti-androgens, has beneficial effects on the hormonal features and asymmetric dimethyl-arginine levels, in women with the polycystic ovary syndrome","volume":"196","author":"Charitidou","year":"2008","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20171013030021_DMR025C35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1477-7827-7-147","article-title":"Direct rosiglitazone action on steroidogenesis and proinflammatory factor production in human granulosa-lutein cells","volume":"7","author":"Chen","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C36","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1373\/clinchem.2005.052753","article-title":"The biological variation of C-reactive protein in polycystic ovarian syndrome","volume":"51","author":"Cho","year":"2005","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20171013030021_DMR025C37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.diabres.2008.04.005","article-title":"Low-grade chronic inflammation is not accompanied by structural arterial injury in polycystic ovary syndrome","volume":"81","author":"Costa","year":"2008","journal-title":"Diabetes Res Clin Pract"},{"key":"key\n\t\t\t\t20171013030021_DMR025C38","first-page":"1799","article-title":"Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis","volume":"294","author":"Danesh","year":"2005","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171013030021_DMR025C39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2265.2007.02849.x","article-title":"Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome","volume":"67","author":"Demirel","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C40","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1210\/jcem.86.10.7904","article-title":"Increased endothelin-1 levels in women with polycystic ovary syndrome and the beneficial effect of metformin therapy","volume":"86","author":"Diamanti-Kandarakis","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1530\/eje.0.1500793","article-title":"The prevalence of 4G5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in polycystic ovarian syndrome and its association with plasma PAI-1 levels","volume":"150","author":"Diamanti-Kandarakis","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1530\/eje.1.01910","article-title":"Metformin administration improves endothelial function in women with polycystic ovary syndrome","volume":"152","author":"Diamanti-Kandarakis","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C43","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.metabol.2005.10.011","article-title":"Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome","volume":"55","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20171013030021_DMR025C44","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2362.2006.01712.x","article-title":"Inflammatory and endothelial markers in women with polycystic ovary syndrome","volume":"36","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t20171013030021_DMR025C45","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/humrep\/del003","article-title":"Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin","volume":"21","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.metabol.2006.09.006","article-title":"Effect of metformin administration on plasma advanced glycation end product levels in women with polycystic ovary syndrome","volume":"56","author":"Diamanti-Kandarakis","year":"2007","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20171013030021_DMR025C47","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2265.2008.03247.x","article-title":"Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS)","volume":"69","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1530\/EJE-07-0822","article-title":"Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?","volume":"158","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C49","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/BF03345631","article-title":"Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome","volume":"31","author":"Diamanti-Kandarakis","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t20171013030021_DMR025C50","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1530\/EJE-08-0510","article-title":"Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome","volume":"160","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/09513590600630447","article-title":"Are polycystic ovaries associated with cardiovascular disease risk as polycystic ovary syndrome?","volume":"22","author":"Engin-Ustun","year":"2006","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2007-992118","article-title":"Thrombin-activatable fibrinolysis inhibitor and cardiovascular risk factors in polycystic ovary syndrome","volume":"116","author":"Erdogan","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t20171013030021_DMR025C53","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1744-313X.2009.00867.x","article-title":"The relationship of the interleukin-6 -174 G>C gene polymorphism with cardiovascular risk factors in Turkish polycystic ovary syndrome patients","volume":"36","author":"Erdogan","year":"2009","journal-title":"Int J Immunogenet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C54","first-page":"3761","article-title":"TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study","volume":"86","author":"Escobar-Morreale","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00125-003-1090-z","article-title":"Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women","volume":"46","author":"Escobar-Morreale","year":"2003","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20171013030021_DMR025C56","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.fertnstert.2010.11.036","article-title":"Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis","volume":"95","author":"Escobar-Morreale","year":"2010","journal-title":"Fertil Steril"},{"issue":"Suppl )1","key":"key\n\t\t\t\t20171013030021_DMR025C57","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.genm.2009.02.004","article-title":"Review of cardiovascular risk factors in women","volume":"6","author":"Evangelista","year":"2009","journal-title":"Gend Med"},{"key":"key\n\t\t\t\t20171013030021_DMR025C58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0015-0282(03)00571-5","article-title":"Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease","volume":"80","author":"Fenkci","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C59","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jadohealth.2009.10.008","article-title":"Obesity-related lipid profile and altered insulin incretion in adolescents with polycystic ovary syndrome","volume":"46","author":"Fulghesu","year":"2010","journal-title":"J Adolesc Health"},{"key":"key\n\t\t\t\t20171013030021_DMR025C60","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/09513590802585613","article-title":"Plasma visfatin level in lean women with PCOS: relation to proinflammatory markers and insulin resistance","volume":"25","author":"Gen","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C61","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2337\/dc07-1424","article-title":"Soluble CD36 and risk markers of insulin resistance and atherosclerosis are elevated in polycystic ovary syndrome and significantly reduced during pioglitazone treatment","volume":"31","author":"Glintborg","year":"2008","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20171013030021_DMR025C62","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1210\/jc.2005-0694","article-title":"Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome","volume":"90","author":"Gonzalez","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C63","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.metabol.2009.02.022","article-title":"Evidence of proatherogenic inflammation in polycystic ovary syndrome","volume":"58","author":"Gonzalez","year":"2009","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20171013030021_DMR025C64","doi-asserted-by":"crossref","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","author":"Goodarzi","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C65","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/09513590701554306","article-title":"Chronic inflammation and elevated homocysteine levels are associated with increased body mass index in women with polycystic ovary syndrome","volume":"23","author":"Guzelmeric","year":"2007","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C66","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1210\/jc.2007-0842","article-title":"Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment","volume":"93","author":"Heutling","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C67","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis","volume":"288","author":"Homocysteine Studies Collaboration","year":"2002","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171013030021_DMR025C68","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.4065\/83.11.1203","article-title":"Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis","volume":"83","author":"Humphrey","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"key\n\t\t\t\t20171013030021_DMR025C69","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09513590802128968","article-title":"Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment","volume":"24","author":"Jakubowska","year":"2008","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C70","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1161\/01.CIR.94.9.2057","article-title":"Fibrinolytic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. ECAT Study Group. European Concerted Action on Thrombosis and Disabilities","volume":"94","author":"Juhan-Vague","year":"1996","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171013030021_DMR025C71","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"Kaptoge","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C72","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2007-992154","article-title":"Oxidative stress markers in young patients with polycystic ovary syndrome, the relationship between insulin resistances","volume":"116","author":"Karadeniz","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t20171013030021_DMR025C73","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/09513590802291824","article-title":"Increased thrombin-activatable fibrinolysis inhibitor antigen levels as a clue for prothrombotic state in polycystic ovary syndrome","volume":"24","author":"Karakurt","year":"2008","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C74","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.fertnstert.2008.08.016","article-title":"Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome","volume":"92","author":"Kaya","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C75","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.rbmo.2009.06.005","article-title":"Obesity and insulin resistance associated with lower plasma vitamin B12 in PCOS","volume":"19","author":"Kaya","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20171013030021_DMR025C76","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.fertnstert.2008.06.006","article-title":"Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study","volume":"92","author":"Kaya","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C77","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fertnstert.2009.02.076","article-title":"C-reactive protein and homocysteine levels are associated with abnormal heart rate recovery in women with polycystic ovary syndrome","volume":"94","author":"Kaya","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C78","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.fertnstert.2009.05.055","article-title":"Relationship between interleukin-6 levels and ambulatory blood pressure in women with polycystic ovary syndrome","volume":"94","author":"Kaya","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C79","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1055\/s-0029-1220770","article-title":"Comparison of the effects of atorvastatin and simvastatin in women with polycystic ovary syndrome: a prospective, randomized study","volume":"118","author":"Kaya","year":"2010","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t20171013030021_DMR025C80","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.fertnstert.2008.10.070","article-title":"Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors","volume":"93","author":"Kaya","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00404-008-0884-0","article-title":"High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome","volume":"280","author":"Kebapcilar","year":"2009","journal-title":"Arch Gynecol Obstet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C82","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","article-title":"Low grade chronic inflammation in women with polycystic ovarian syndrome","volume":"86","author":"Kelly","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C83","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1210\/jcem.87.7.8634","article-title":"A specific elevation in tissue plasminogen activator antigen in women with polycystic ovarian syndrome","volume":"87","author":"Kelly","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C84","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1507\/endocrj.51.505","article-title":"Relationship between homocysteine and insulin resistance in women with polycystic ovary syndrome","volume":"51","author":"Kilic-Okman","year":"2004","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t20171013030021_DMR025C85","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1055\/s-2008-1058085","article-title":"Increased low grade inflammatory serum markers in patients with Polycystic ovary syndrome (PCOS) and their relationship to PPARgamma gene variants","volume":"116","author":"Knebel","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t20171013030021_DMR025C86","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.2337\/dc07-1872","article-title":"Insulin resistance is associated with decreased circulating mannan-binding lectin concentrations in women with polycystic ovary syndrome","volume":"31","author":"Kowalska","year":"2008","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20171013030021_DMR025C87","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3109\/09513591003686387","article-title":"The role of chronic inflammation and Leu55Met PON1 polymorphism in the pathogenesis of polycystic ovary syndrome","volume":"26","author":"Lenarcik","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C88","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijgo.2007.09.019","article-title":"Plasminogen activator and plasma activator inhibitor-1 in young women with polycystic ovary syndrome","volume":"100","author":"Lin","year":"2008","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C89","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12020-009-9255-2","article-title":"The plasminogen activator inhibitor-1 (PAI-1) gene -844 A\/G and -675 4G\/5G promoter polymorphism significantly influences plasma PAI-1 levels in women with polycystic ovary syndrome","volume":"36","author":"Lin","year":"2009","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20171013030021_DMR025C90","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3109\/09513590.2010.487592","article-title":"Tissue plasminogen activator and plasminogen activator inhibitor 1 in obese and lean patients with polycystic ovary syndrome","volume":"26","author":"Lindholm","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C91","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1210\/jc.2005-2430","article-title":"Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome","volume":"91","author":"Lo","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C92","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1530\/EJE-08-0725","article-title":"Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking","volume":"160","author":"Luque-Ramirez","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C93","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/0003319709361198","article-title":"Serum high-sensitivity C-reactive protein and homocysteine changes during hormonal therapy in women with polycystic ovary syndrome: a prospective, matched study","volume":"61","author":"Makedos","year":"2010","journal-title":"Angiology"},{"key":"key\n\t\t\t\t20171013030021_DMR025C94","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.fertnstert.2008.03.023","article-title":"Endothelial function and its relationship to leptin, homocysteine, and insulin resistance in lean and overweight eumenorrheic women and PCOS patients: a pilot study","volume":"91","author":"Mancini","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C95","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.fertnstert.2008.12.008","article-title":"Hepatic steatosis in young lean insulin resistant women with polycystic ovary syndrome","volume":"93","author":"Markou","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C96","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2337\/dc09-0420","article-title":"Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism","volume":"32","author":"Martinez-Garcia","year":"2009","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20171013030021_DMR025C97","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijgo.2007.06.005","article-title":"Metabolic and cardiovascular changes in women with polycystic ovary syndrome","volume":"99","author":"Meden-Vrtovec","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C98","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1210\/jc.2005-0011","article-title":"Overweight women with polycystic ovary syndrome have evidence of subclinical cardiovascular disease","volume":"90","author":"Meyer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C99","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/0256-4947.65255","article-title":"Cardiovascular disease markers in women with polycystic ovary syndrome with emphasis on asymmetric dimethylarginine and homocysteine","volume":"30","author":"Mohamadin","year":"2010","journal-title":"Ann Saudi Med"},{"key":"key\n\t\t\t\t20171013030021_DMR025C100","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1530\/eje.0.1500525","article-title":"The polycystic ovary syndrome per se is not associated with increased chronic inflammation","volume":"150","author":"Mohlig","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C101","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/jc.2006-2336","article-title":"C-reactive protein before and after weight loss in overweight women with and without polycystic ovary syndrome","volume":"92","author":"Moran","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C102","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/CS20080218","article-title":"A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome","volume":"116","author":"Moran","year":"2009","journal-title":"Clin Sci (Lond)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C103","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF03345790","article-title":"Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention","volume":"33","author":"Moran","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t20171013030021_DMR025C104","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejogrb.2006.09.009","article-title":"Nitric oxide and fibrinogen in polycystic ovary syndrome: associations with insulin resistance and obesity","volume":"133","author":"Nacul","year":"2007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C105","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.fertnstert.2008.12.024","article-title":"The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome","volume":"93","author":"Nafiye","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C106","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pathophys.2006.09.006","article-title":"Acute phase proteins: C-reactive protein and fibrinogen in young women with polycystic ovary syndrome","volume":"14","author":"Nasiek","year":"2007","journal-title":"Pathophysiology"},{"key":"key\n\t\t\t\t20171013030021_DMR025C107","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/humrep\/deh853","article-title":"Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome","volume":"20","author":"Ng","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C108","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.2337\/db09-1316","article-title":"Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome","volume":"59","author":"Nikolajuk","year":"2010","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20171013030021_DMR025C109","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.cyto.2010.12.005","article-title":"Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: comparison with C-reactive protein","volume":"53","author":"Nishida","year":"2010","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20171013030021_DMR025C110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3904\/kjim.2009.24.4.350","article-title":"Serum C-reactive protein levels in normal-weight polycystic ovary syndrome","volume":"24","author":"Oh","year":"2009","journal-title":"Korean J Intern Med"},{"key":"key\n\t\t\t\t20171013030021_DMR025C111","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/j.fertnstert.2008.03.039","article-title":"Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease","volume":"91","author":"Oktem","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C112","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejogrb.2006.10.037","article-title":"Is the polycystic ovary syndrome associated with chronic inflammation per se?","volume":"133","author":"Olszanecka-Glinianowicz","year":"2007","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C113","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1034\/j.1600-0412.2003.00045.x","article-title":"Differential expression of T-helper cytokines in the peritoneal fluid of women with normal ovarian cycle compared with women with chronic anovulation","volume":"82","author":"Omu","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"key":"key\n\t\t\t\t20171013030021_DMR025C114","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/09513590802549874","article-title":"Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome","volume":"25","author":"Oral","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C115","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1210\/jc.2002-021142","article-title":"Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate reductase in women with polycystic ovary syndrome","volume":"88","author":"Orio","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C116","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1210\/jc.2003-031867","article-title":"Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome","volume":"89","author":"Orio","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C117","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1472-6483(10)61634-3","article-title":"Is plasminogen activator inhibitor-1 a cardiovascular risk factor in young women with polycystic ovary syndrome?","volume":"9","author":"Orio","year":"2004","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20171013030021_DMR025C118","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1210\/jc.2004-0628","article-title":"The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome","volume":"90","author":"Orio","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C119","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1210\/jc.2006-0216","article-title":"Cardiopulmonary impairment in young women with polycystic ovary syndrome","volume":"91","author":"Orio","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C120","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.atherosclerosis.2007.12.054","article-title":"Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS)","volume":"200","author":"Ozgurtas","year":"2008","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20171013030021_DMR025C121","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa040967","article-title":"Inflammatory markers and the risk of coronary heart disease in men and women","volume":"351","author":"Pai","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171013030021_DMR025C122","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/14647270600950157","article-title":"Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study","volume":"10","author":"Palep-Singh","year":"2007","journal-title":"Hum Fertil (Camb)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C123","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejogrb.2007.12.015","article-title":"Plasma homocysteine concentrations and the single nucleotide polymorphisms in the methionine synthase gene (MTR 2756A>G): associations with the polycystic ovary syndrome an observational study","volume":"138","author":"Palep-Singh","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C124","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2337\/dc09-1516","article-title":"Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome","volume":"33","author":"Palomba","year":"2010","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20171013030021_DMR025C125","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.fertnstert.2008.10.073","article-title":"Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters","volume":"93","author":"Pamuk","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C126","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1210\/jc.2002-020386","article-title":"Troglitazone therapy improves endothelial function to near normal levels in women with polycystic ovary syndrome","volume":"88","author":"Paradisi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C127","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171013030021_DMR025C128","first-page":"28","article-title":"PCR ultrasensible en mujeres con s\u00edndrome de ovario poliqu\u00edstico: posible marcador de riesgo cardiovascular","volume":"26","author":"Perez Calvo","year":"2009","journal-title":"Fertilidad"},{"key":"key\n\t\t\t\t20171013030021_DMR025C129","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1210\/jc.2005-1002","article-title":"Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance","volume":"90","author":"Puder","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C130","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1365-2362.2006.01734.x","article-title":"Women with polycystic ovary syndrome are sensitive to the TNF-alpha-lowering effect of glucose-induced hyperinsulinaemia","volume":"36","author":"Puder","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t20171013030021_DMR025C131","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.atherosclerosis.2008.09.010","article-title":"Polycystic ovary syndrome is associated with severe platelet and endothelial dysfunction in both obese and lean subjects","volume":"204","author":"Rajendran","year":"2009","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20171013030021_DMR025C132","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1447-0578.2005.00114.x","article-title":"Cytokines and leptin correlation in patients with polycystic ovary syndrome: biochemical evaluation in south Indian population","volume":"4","author":"Ravishankar Ram","year":"2005","journal-title":"Reprod Med Biol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C133","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/humrep\/dep121","article-title":"Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype","volume":"24","author":"Rizzo","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C134","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171013030021_DMR025C135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C136","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000189809","article-title":"Study on chronic low-grade inflammation and influential factors of polycystic ovary syndrome","volume":"18","author":"Ruan","year":"2009","journal-title":"Med Princ Pract"},{"key":"key\n\t\t\t\t20171013030021_DMR025C137","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1365-2265.2007.02985.x","article-title":"The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndrome","volume":"67","author":"Sahin","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C138","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1155\/2009\/465203","article-title":"Clinical significance of inflammatory markers in polycystic ovary syndrome: their relationship to insulin resistance and body mass index","volume":"26","author":"Samy","year":"2009","journal-title":"Dis Markers"},{"key":"key\n\t\t\t\t20171013030021_DMR025C139","first-page":"165","article-title":"Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome","volume":"48","author":"Sayin","year":"2003","journal-title":"J Reprod Med"},{"key":"key\n\t\t\t\t20171013030021_DMR025C140","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/humrep\/deg190","article-title":"Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine","volume":"18","author":"Schachter","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C141","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1161\/01.RES.0000181286.44222.61","article-title":"Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study","volume":"97","author":"Schnabel","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C142","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1210\/jc.2007-1343","article-title":"Young obese women with polycystic ovary syndrome have evidence of early coronary atherosclerosis","volume":"92","author":"Shroff","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C143","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/gye.17.3.231.237","article-title":"Absence of profound hyperinsulinism in polycystic ovary syndrome is associated with subtle elevations in the plasminogen activator inhibitor system","volume":"17","author":"Sills","year":"2003","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C144","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/09513590601005805","article-title":"Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity","volume":"22","author":"Slopien","year":"2006","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C145","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2265.2008.03506.x","article-title":"Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome?","volume":"71","author":"Soares","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C146","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1210\/jcem.87.5.8471","article-title":"Menstrual cycle irregularity and risk for future cardiovascular disease","volume":"87","author":"Solomon","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C147","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.fertnstert.2010.03.049","article-title":"Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome","volume":"94","author":"Sova","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C148","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/cvr\/cvp131","article-title":"Metformin decreases angiogenesis via NF-kappaB and Erk1\/2\/Erk5 pathways by increasing the antiangiogenic thrombospondin-1","volume":"83","author":"Tan","year":"2009","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C149","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1210\/jc.2004-0751","article-title":"Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation","volume":"89","author":"Tarkun","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C150","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1507\/endocrj.51.467","article-title":"The plasminogen activator system in young and lean women with polycystic ovary syndrome","volume":"51","author":"Tarkun","year":"2004","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t20171013030021_DMR025C151","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1089\/met.2006.4.122","article-title":"Association between circulating tumor necrosis factor-alpha, interleukin-6, and insulin resistance in normal-weight women with polycystic ovary syndrome","volume":"4","author":"Tarkun","year":"2006","journal-title":"Metab Syndr Relat Disord"},{"key":"key\n\t\t\t\t20171013030021_DMR025C152","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/09513590801893398","article-title":"Differences in low-grade chronic inflammation and insulin resistance in women with previous gestational diabetes mellitus and women with polycystic ovary syndrome","volume":"24","author":"Thomann","year":"2008","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C153","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/j.1471-0528.2009.02177.x","article-title":"Comparison of aerobic exercise capacity and muscle strength in overweight women with and without polycystic ovary syndrome","volume":"116","author":"Thomson","year":"2009","journal-title":"BJOG"},{"key":"key\n\t\t\t\t20171013030021_DMR025C154","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/humrep\/dei431","article-title":"Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease?","volume":"21","author":"Topcu","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C155","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1530\/EJE-09-0379","article-title":"Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome","volume":"161","author":"Tosi","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C156","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.fertnstert.2008.06.045","article-title":"Risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and a meta-analysis","volume":"92","author":"Toulis","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C157","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0015-0282(00)00684-1","article-title":"Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome","volume":"74","author":"Tulandi","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C158","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0026-0495(97)90066-4","article-title":"Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome","volume":"46","author":"Velazquez","year":"1997","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20171013030021_DMR025C159","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00404-009-1226-6","article-title":"High sensitive serum C-reactive protein and its relationship with other cardiovascular risk factors in normoinsulinemic polycystic ovary patients without metabolic syndrome","volume":"281","author":"Verit","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C160","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.metabol.2006.04.002","article-title":"Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea","volume":"55","author":"Vgontzas","year":"2006","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20171013030021_DMR025C161","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1210\/jc.2009-0466","article-title":"Mitochondrial complex I impairment in leukocytes from polycystic ovary syndrome patients with insulin resistance","volume":"94","author":"Victor","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C162","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-2002-23489","article-title":"Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome","volume":"110","author":"Vrbikova","year":"2002","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t20171013030021_DMR025C163","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1365-2265.2004.02019.x","article-title":"Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity?","volume":"60","author":"Wijeyaratne","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171013030021_DMR025C164","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/jc.2009-2724","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society","volume":"95","author":"Wild","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fertnstert.2007.11.031","article-title":"Increased acylation-stimulating protein, C-reactive protein,and lipid levels in young women with polycystic ovary syndrome","volume":"91","author":"Wu","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C166","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ijgo.2009.02.004","article-title":"Apnea\u2013hypopnea index in nonobese women with polycystic ovary syndrome","volume":"105","author":"Yang","year":"2009","journal-title":"Int J Gynecol Obstet"},{"key":"key\n\t\t\t\t20171013030021_DMR025C167","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(01)01937-9","article-title":"Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome","volume":"76","author":"Yarali","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013030021_DMR025C168","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1210\/jcem.87.8.8716","article-title":"Global fibrinolytic capacity is decreased in polycystic ovary syndrome, suggesting a prothrombotic state","volume":"87","author":"Yildiz","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013030021_DMR025C169","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/09513590400027265","article-title":"Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome","volume":"20","author":"Yilmaz","year":"2005","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20171013030021_DMR025C170","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1093\/humrep\/dei258","article-title":"The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome","volume":"20","author":"Yilmaz","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013030021_DMR025C171","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1447-0756.2007.00699.x","article-title":"The correlation of plasma homocysteine with insulin resistance in polycystic ovary syndrome","volume":"34","author":"Yilmaz","year":"2008","journal-title":"J Obstet Gynaecol Res"},{"key":"key\n\t\t\t\t20171013030021_DMR025C172","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome; towards a rational approach","volume-title":"Polycystic Ovary Syndrome","author":"Zawadski","year":"1992"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/17\/6\/741\/17055669\/dmr025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T07:00:43Z","timestamp":1507878043000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humupd\/article\/17\/6\/741\/870911\/Metaanalysis-of-cardiovascular-disease-risk"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,30]]},"references-count":172,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,5,30]]},"published-print":{"date-parts":[[2011,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmr025","relation":{},"ISSN":["1460-2369","1355-4786"],"issn-type":[{"value":"1460-2369","type":"electronic"},{"value":"1355-4786","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,11]]},"published":{"date-parts":[[2011,5,30]]}}}