{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:50:49Z","timestamp":1785235849293,"version":"3.55.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"DOI":"10.1093\/humupd\/dmr030","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T03:37:29Z","timestamp":1310009849000},"page":"791-802","source":"Crossref","is-referenced-by-count":41,"title":["The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies"],"prefix":"10.1093","volume":"17","author":[{"given":"Nick","family":"Pullen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Birch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry J.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Pruimboom-Brees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind J.","family":"Walley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,7,6]]},"reference":[{"key":"key\n\t\t\t\t20171013025655_DMR030C1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","year":"1997","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C2","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1093\/humrep\/dep275","article-title":"Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study","volume":"24","author":"Al-Jefout","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C3","first-page":"CD004753","article-title":"Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis","author":"Allen","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20171013025655_DMR030C4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1124\/jpet.110.166488","article-title":"A long-acting tumor necrosis factor alpha-binding protein demonstrates activity in both in vitro and in vivo models of endometriosis","volume":"334","author":"Altan","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"issue":"Suppl 1","key":"key\n\t\t\t\t20171013025655_DMR030C5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.fertnstert.2003.09.034","article-title":"Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons","volume":"81","author":"Barrier","year":"2004","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C6","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2353\/ajpath.2006.051133","article-title":"A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy","volume":"168","author":"Becker","year":"2006","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C7","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0403663101","article-title":"Innervation of ectopic endometrium in a rat model of endometriosis","volume":"101","author":"Berkley","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171013025655_DMR030C8","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.1111445","article-title":"The pains of endometriosis","volume":"308","author":"Berkley","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20171013025655_DMR030C9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0002-9378(81)90478-6","article-title":"Dosage aspects of danazol therapy in endometriosis: short-term and long-term effectiveness","volume":"139","author":"Biberoglu","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C10","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1093\/humrep\/dep283","article-title":"Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis","volume":"24","author":"Bokor","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C11","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2353\/ajpath.2010.090551","article-title":"Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis","volume":"176","author":"Chuang","year":"2010","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejogrb.2004.02.007","article-title":"The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis","volume":"116","author":"Cobellis","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C13","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988","edition":"2nd edn"},{"key":"key\n\t\t\t\t20171013025655_DMR030C14","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1093\/humrep\/den167","article-title":"Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial","volume":"23","author":"Creus","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-0378(00)00073-5","article-title":"Ability of recombinant human TNF binding protein-1 (r-hTBP-1) to inhibit the development of experimentally-induced endometriosis in rats","volume":"48","author":"D'Antonio","year":"2000","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1095\/biolreprod.105.043349","article-title":"Recombinant human TNFRSF1A (r-hTBP1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study","volume":"74","author":"D'Hooghe","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1933719108322430","article-title":"Nonhuman primate models for translational research in endometriosis","volume":"16","author":"D'Hooghe","year":"2009","journal-title":"Reprod Sci"},{"key":"key\n\t\t\t\t20171013025655_DMR030C18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00001703-200312000-00009","article-title":"Pain in endometriosis: effectiveness of medical and surgical management","volume":"15","author":"Davis","year":"2003","journal-title":"Curr Opin Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.pain.2010.08.037","article-title":"Endocannabinoid involvement in endometriosis","volume":"151","author":"Dmitrieva","year":"2010","journal-title":"PAIN"},{"issue":"Suppl 3","key":"key\n\t\t\t\t20171013025655_DMR030C20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.fertnstert.2004.06.033","article-title":"Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib","volume":"82","author":"Dogan","year":"2004","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.fertnstert.2004.06.058","article-title":"Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model","volume":"83","author":"Efstathiou","year":"2005","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C22","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/humrep\/del044","article-title":"Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon","volume":"21","author":"Falconer","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.fertnstert.2007.05.062","article-title":"Effects of anti-TNF-mAb treatment on pregnancy in baboons with induced endometriosis","volume":"89","author":"Falconer","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C24","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.fertnstert.2006.07.1550","article-title":"Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease","volume":"87","author":"Flores","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C25","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.fertnstert.2008.04.007","article-title":"Sensory nerve endings and endometriotic implants","volume":"89","author":"Fraser","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/humupd\/dml026","article-title":"Animal models in endometriosis research","volume":"12","author":"Grummer","year":"2006","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171013025655_DMR030C27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/humupd\/dmp007","article-title":"Recurrence of endometriosis and its control","volume":"15","author":"Guo","year":"2009","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171013025655_DMR030C28","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/humrep\/dep045","article-title":"A call for more transparency of registered clinical trials on endometriosis","volume":"24","author":"Guo","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C29","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1093\/humrep\/deq248","article-title":"Aberrant expression of regulators of cell-fate found in eutopic endometrium is found in matched ectopic endometrium among women and in a baboon model of endometriosis","volume":"25","author":"Hapangama","year":"2010","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C30","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/humrep\/deh611","article-title":"Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis","volume":"20","author":"Hull","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C31","doi-asserted-by":"crossref","first-page":"700","DOI":"10.2353\/ajpath.2008.071128","article-title":"Endometrial-peritoneal interactions during endometriotic lesion establishment","volume":"173","author":"Hull","year":"2008","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C32","first-page":"824","article-title":"Tumor necrosis factor-alpha promotes proliferation of endometriotic stromal cells by inducing interleukin-8 gene and protein expression","volume":"85","author":"Iwabe","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013025655_DMR030C33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0976-500X.72351","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"1","author":"Kilkenny","year":"2010","journal-title":"J Pharmacol Pharmacother"},{"key":"key\n\t\t\t\t20171013025655_DMR030C34","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/humrep\/den177","article-title":"Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial","volume":"23","author":"Koninckx","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1600-0897.2007.00507.x","article-title":"Gene expression profiling of the rat endometriosis model","volume":"58","author":"Konno","year":"2007","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C36","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/humrep\/deq201","article-title":"Size and spatial orientation of uterine tissue transplants on the peritoneum crucially determine the growth and cyst formation of endometriosis-like lesions in mice","volume":"25","author":"Korbel","year":"2010","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jri.2010.02.008","article-title":"DNA microarray analysis in a mouse model for endometriosis and validation of candidate factors with human adenomyosis","volume":"85","author":"Kusakabe","year":"2010","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/humupd\/dmm006","article-title":"In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis","volume":"13","author":"Laschke","year":"2007","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171013025655_DMR030C39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.fertnstert.2006.05.068","article-title":"Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis","volume":"87","author":"Laschke","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2353\/ajpath.2010.090617","article-title":"High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models","volume":"176","author":"Laschke","year":"2010","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pharmthera.2007.05.002","article-title":"Clinical attrition due to biased preclinical assessments of potential efficacy","volume":"115","author":"Lindner","year":"2007","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20171013025655_DMR030C42","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/j.1447-0756.2010.01345.x","article-title":"Improved nude mouse models for green fluorescence human endometriosis","volume":"36","author":"Liu","year":"2010","journal-title":"J Obstet Gynaecol Res"},{"key":"key\n\t\t\t\t20171013025655_DMR030C43","first-page":"CD008088","article-title":"Anti-TNF-alpha treatment for pelvic pain associated with endometriosis","author":"Lv","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20171013025655_DMR030C44","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1016\/j.fertnstert.2009.11.037","article-title":"A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model","volume":"93","author":"Machado","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C45","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1161\/STROKEAHA.108.525386","article-title":"Good laboratory practice: preventing introduction of bias at the bench","volume":"40","author":"Macleod","year":"2009","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20171013025655_DMR030C46","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.fertnstert.2004.07.946","article-title":"Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats","volume":"82","author":"Matsuzaki","year":"2004","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pain.2009.09.022","article-title":"Endometriosis-induced vaginal hyperalgesia in the rat: Role of the ectopic growths and their innervation","volume":"147","author":"McAllister","year":"2009","journal-title":"PAIN"},{"key":"key\n\t\t\t\t20171013025655_DMR030C48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000092023","article-title":"Endometriosis in patients with chronic pelvic pain: is staging predictive of the efficacy of laparoscopic surgery in pain relief?","volume":"62","author":"Milingos","year":"2006","journal-title":"Gynecol Obstet Invest"},{"key":"key\n\t\t\t\t20171013025655_DMR030C49","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(00)04337-3","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials","volume":"357","author":"Moher","year":"2001","journal-title":"Lancet"},{"issue":"Suppl 1","key":"key\n\t\t\t\t20171013025655_DMR030C50","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1016\/j.pain.2007.04.039","article-title":"Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat","volume":"132","author":"Nagabukuro","year":"2007","journal-title":"PAIN"},{"key":"key\n\t\t\t\t20171013025655_DMR030C51","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.fertnstert.2009.05.065","article-title":"Fenofibrate causes regression of endometriotic implants: a rat model","volume":"92","author":"Onalan","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C52","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.fertnstert.2006.01.057","article-title":"A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice","volume":"86","author":"Ozawa","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2008.08.017","article-title":"Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards","volume":"139","author":"Rice","year":"2008","journal-title":"PAIN"},{"key":"key\n\t\t\t\t20171013025655_DMR030C54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/1933719108330568","article-title":"Priorities for endometriosis research: recommendations from an international consensus workshop","volume":"16","author":"Rogers","year":"2009","journal-title":"Reprod Sci"},{"key":"key\n\t\t\t\t20171013025655_DMR030C55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/1933719108330568","article-title":"Priorities for endometriosis research: recommendations from an international consensus workshop","volume":"16","author":"Rogers","year":"2009","journal-title":"Reprod Sci"},{"key":"key\n\t\t\t\t20171013025655_DMR030C56","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2307\/3002019","article-title":"An approximate distribution of estimates of variance components","volume":"2","author":"Satterthwaite","year":"1946","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t20171013025655_DMR030C57","first-page":"269","article-title":"Modern concepts of endometriosis. Classification and its consequences for therapy","volume":"43","author":"Schenken","year":"1998","journal-title":"J Reprod Med"},{"key":"key\n\t\t\t\t20171013025655_DMR030C58","doi-asserted-by":"crossref","first-page":"e1000344","DOI":"10.1371\/journal.pbio.1000344","article-title":"Publication bias in reports of animal stroke studies leads to major overstatement of efficacy","volume":"8","author":"Sena","year":"2010","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C59","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2741\/e41","article-title":"Treatment of endometriosis-related pain: options and outcomes","volume":"1","author":"Somigliana","year":"2009","journal-title":"Front Biosci (Elite Ed)"},{"key":"key\n\t\t\t\t20171013025655_DMR030C60","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/01.AOG.0000297307.35024.b5","article-title":"Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial","volume":"111","author":"Stratton","year":"2008","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013025655_DMR030C61","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/humrep\/dei368","article-title":"High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis","volume":"21","author":"Tokushige","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C62","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1093\/humrep\/del260","article-title":"Nerve fibres in peritoneal endometriosis","volume":"21","author":"Tokushige","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C63","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.fertnstert.2006.12.078","article-title":"Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis","volume":"88","author":"Tokushige","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C64","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.fertnstert.2008.07.1774","article-title":"Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis","volume":"92","author":"Tokushige","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013025655_DMR030C65","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pharmthera.2007.10.001","article-title":"Tumor necrosis factor antagonist mechanisms of action: a comprehensive review","volume":"117","author":"Tracey","year":"2008","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20171013025655_DMR030C66","doi-asserted-by":"crossref","first-page":"e1000245","DOI":"10.1371\/journal.pmed.1000245","article-title":"Can animal models of disease reliably inform human studies?","volume":"7","author":"van der Worp","year":"2010","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20171013025655_DMR030C67","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/humrep\/del339","article-title":"Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients","volume":"22","author":"Vercellini","year":"2007","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C68","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2165\/00003495-200969060-00002","article-title":"Endometriosis: current therapies and new pharmacological developments","volume":"69","author":"Vercellini","year":"2009","journal-title":"Drugs"},{"key":"key\n\t\t\t\t20171013025655_DMR030C69","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humrep\/deq302","article-title":"\u2018Waiting for Godot\u2019: a commonsense approach to the medical treatment of endometriosis","volume":"26","author":"Vercellini","year":"2011","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C70","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/humrep\/den464","article-title":"Rich innervation of deep infiltrating endometriosis","volume":"24","author":"Wang","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C71","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/humrep\/den417","article-title":"Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model","volume":"24","author":"Xu","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013025655_DMR030C72","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00404-010-1543-9","article-title":"Etanercept causes regression of endometriotic implants in a rat model","volume":"283","author":"Yildirim","year":"2011","journal-title":"Arch Gynecol Obstet"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/17\/6\/791\/17055978\/dmr030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T06:57:06Z","timestamp":1507877826000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humupd\/article\/17\/6\/791\/874711\/The-translational-challenge-in-the-development-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,6]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,7,6]]},"published-print":{"date-parts":[[2011,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmr030","relation":{},"ISSN":["1460-2369","1355-4786"],"issn-type":[{"value":"1460-2369","type":"electronic"},{"value":"1355-4786","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,11]]},"published":{"date-parts":[[2011,7,6]]}}}