{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:27Z","timestamp":1790704887226,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"DOI":"10.1093\/humupd\/dmu033","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T01:02:38Z","timestamp":1403658158000},"page":"840-852","source":"Crossref","is-referenced-by-count":226,"title":["A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF\/ICSI compared with children conceived spontaneously"],"prefix":"10.1093","volume":"20","author":[{"given":"Gabija","family":"Lazaraviciute","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohinee","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Haggarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siladitya","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"key\n\t\t\t\t20171013013208_DMU033C1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.fertnstert.2011.09.037","article-title":"Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?","volume":"96","year":"2011","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C2","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1093\/hmg\/ddp445","article-title":"Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns","volume":"18","year":"2009","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/jama.2013.7223","article-title":"In vitro fertilization and risk of autistic disorder and mental retardation","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171013013208_DMU033C4","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1210\/jc.2006-2896","article-title":"Body composition in children and adolescents born after in vitro fertilization or spontaneous conception","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013013208_DMU033C5","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/jc.2007-2432","article-title":"Cardiometabolic differences in children born after in vitro fertilization: follow-up study","volume":"93","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013013208_DMU033C6","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.fertnstert.2011.05.047","article-title":"DNA methylation at H19\/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection","volume":"95","year":"2011","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C7","first-page":"77","article-title":"DNA methylation at H19\/IGF2 ICR1 in the placenta of pregnancies conceived by IVF and ICSI","volume":"26","year":"2011","journal-title":"Human Reproduction. Conference: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, ESHRE 2011 Stockholm Sweden. Conference Start: 20110703 Conference End: 20110706. Conference Publication: (var.pagings)"},{"key":"key\n\t\t\t\t20171013013208_DMU033C8","article-title":"Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171013013208_DMU033C9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/01.ogx.0000421443.42267.9d","article-title":"Reproductive technologies and the risk of birth defects","volume":"67","year":"2012","journal-title":"Obstet Gynecol Surv"},{"key":"key\n\t\t\t\t20171013013208_DMU033C10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jech.52.6.377","article-title":"The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions","volume":"52","year":"1998","journal-title":"J Epidemiol Community Health"},{"key":"key\n\t\t\t\t20171013013208_DMU033C11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1472-6483(10)62061-5","article-title":"Aspects of the molecular regulation of early mammalian development","volume":"6","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20171013013208_DMU033C12","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.fertnstert.2011.09.033","article-title":"General imprinting status is stable in assisted reproduction-conceived offspring","volume":"96","year":"2011","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cmet.2011.01.011","article-title":"You are what your dad ate","volume":"13","year":"2011","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20171013013208_DMU033C14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.placenta.2006.01.015","article-title":"Epigenetics and imprinting of the trophoblast\u2014a workshop report","volume":"27","year":"2006","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20171013013208_DMU033C15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1274\/jmor.27.51","article-title":"Investigation of imprinted gene expression for in vitro fertilized mouse embryos","volume":"27","year":"2010","journal-title":"J Mamm Ova Res"},{"key":"key\n\t\t\t\t20171013013208_DMU033C16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/molehr\/gap038","article-title":"Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies","volume":"15","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C17","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(03)13592-1","article-title":"Rare congenital disorders, imprinted genes, and assisted reproductive technology","volume":"361","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ydbio.2008.04.025","article-title":"Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae","volume":"320","year":"2008","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20171013013208_DMU033C19","doi-asserted-by":"crossref","first-page":"20110328","DOI":"10.1098\/rstb.2011.0328","article-title":"DNA methylation dynamics during the mammalian life cycle","volume":"368","year":"2013","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key\n\t\t\t\t20171013013208_DMU033C20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/acprof:oso\/9780199656516.003.0015","article-title":"Life course epigenetics and healthy ageing","volume-title":"A Life Course Approach to Healthy Ageing","year":"2013"},{"key":"key\n\t\t\t\t20171013013208_DMU033C21","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1086\/423902","article-title":"Beckwith-Wiedemann syndrome and IVF: a case-control study [4]","volume":"75","year":"2004","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C22","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.fertnstert.2009.09.010","article-title":"Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility","volume":"94","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1054\/ebog.2002.0088","article-title":"Children conceived by IVF or ICSI were twice as likely as naturally conceived children to have major birth defects","volume":"4","year":"2002","journal-title":"Evid Based Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013013208_DMU033C24","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/AOG.0b013e318269c282","article-title":"Assisted reproductive technology and major birth defects in Western Australia","volume":"120","year":"2012","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171013013208_DMU033C25","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/humupd\/dmt006","article-title":"Assisted reproductive technology and birth defects: A systematic review and meta-analysis","volume":"19","year":"2013","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171013013208_DMU033C26","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/humrep\/des197","article-title":"Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C27","doi-asserted-by":"crossref","first-page":"g252","DOI":"10.1136\/bmj.g252","article-title":"Are we overusing IVF?","volume":"348","author":"the Evidence Based IVF Group","year":"2014","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20171013013208_DMU033C28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0079-6123(10)82006-0","article-title":"Assisted reproduction and its neuroendocrine impact on the offspring","volume":"182","year":"2010","journal-title":"Prog Brain Res"},{"key":"key\n\t\t\t\t20171013013208_DMU033C29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ejhg.2008.177","article-title":"Low frequency of imprinting defects in ICSI children born small for gestational age","volume":"17","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C30","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1093\/hmg\/ddp319","article-title":"DNA methylation and gene expression differences in children conceived in vitro or in vivo","volume":"18","year":"2009","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C31","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.rbmo.2010.01.011","article-title":"Skewed X inactivation and IVF-conceived infants","volume":"20","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20171013013208_DMU033C32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ando.2010.02.004","article-title":"Epigenetics, genomic imprinting and assisted reproductive technology","volume":"71","year":"2010","journal-title":"Ann Endocrinol"},{"key":"key\n\t\t\t\t20171013013208_DMU033C33","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.fertnstert.2011.01.173","article-title":"Evaluation of DNA methylation status at differentially methylated regions in IVF-conceived newborn twins","volume":"95","year":"2011","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C34","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/humrep\/deh714","article-title":"Imprinting diseases and IVF: Danish National IVF cohort study","volume":"20","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.fertnstert.2009.01.002","article-title":"Imprinting disorders and assisted reproductive technology","volume":"91","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C36","doi-asserted-by":"crossref","first-page":"A56","DOI":"10.1016\/j.placenta.2013.06.167","article-title":"Comparison of genome-wide and gene-specific DNA methylation between pregnancies conceived naturally versus ART (assisted reproductive technologies)","volume":"34","year":"2013","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20171013013208_DMU033C37","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/humrep\/des459","article-title":"Placentas from pregnancies conceived by IVF\/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions","volume":"28","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/MED.0b013e32834040a3","article-title":"Imprinting disorders and assisted reproductive technology","volume":"17","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"key\n\t\t\t\t20171013013208_DMU033C39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fertnstert.2011.10.027","article-title":"Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population","volume":"97","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1055\/s-0029-1237430","article-title":"Imprinting disorders and assisted reproductive technology","volume":"27","year":"2009","journal-title":"Semin Reprod Med"},{"key":"key\n\t\t\t\t20171013013208_DMU033C41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2431-12-33","article-title":"Similar DNA methylation levels in specific imprinting control regions in children conceived with and without assisted reproductive technology: a cross-sectional study","volume":"12","year":"2012","journal-title":"BMC Pediatr"},{"key":"key\n\t\t\t\t20171013013208_DMU033C42","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/humrep\/des151","article-title":"Methylation levels at imprinting control regions are not altered with ovulation induction or in vitro fertilization in a birth cohort","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C43","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/jmg.2006.042135","article-title":"The epigenetic imprinting defect of patients with Beckwith-Wiedemann syndrome born after assisted reproductive technology is not restricted to the 11p15 region","volume":"43","year":"2006","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C44","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1210\/jc.2008-1624","article-title":"Euthyroid hyperthyrotropinemia in children born after in vitro fertilization","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171013013208_DMU033C45","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.fertnstert.2009.09.049","article-title":"Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization","volume":"94","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1469-8749.2007.00129.x","article-title":"Increased frequency of severe major anomalies in children conceived by intracytoplasmic sperm injection","volume":"49","year":"2007","journal-title":"Dev Med Child Neurol"},{"key":"key\n\t\t\t\t20171013013208_DMU033C47","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/hmg\/ddg167","article-title":"Familial aggregation of abnormal methylation of parental alleles at the IGF2\/H19 and IGF2R differentially methylated regions","volume":"12","year":"2003","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrg2295","article-title":"Epigenetic events in mammalian germ-cell development: reprogramming and beyond","volume":"9","year":"2008","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/humrep\/del316","article-title":"Aberrant DNA methylation of imprinted loci in superovulated oocytes","volume":"22","year":"2007","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jmg.2009.073189","article-title":"Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in human","volume":"47","year":"2010","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C51","doi-asserted-by":"crossref","first-page":"e1001033","DOI":"10.1371\/journal.pgen.1001033","article-title":"Inter- and intra-individual variation in allele-specific DNA methylation and gene expression in children conceived using assisted reproductive technology","volume":"6","year":"2010","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C52","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.fertnstert.2013.01.125","article-title":"Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection?","volume":"99","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171013013208_DMU033C53","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1373\/clinchem.2005.065086","article-title":"Quantitative analysis of SRNPN gene methylation by pyrosequencing as a diagnostic test for Prader-Willi syndrome and Angelman syndrome","volume":"52","year":"2006","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20171013013208_DMU033C54","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrg1062","article-title":"What good is genomic imprinting: the function of parent-specific gene expression","volume":"4","year":"2003","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20171013013208_DMU033C55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8935-4-1","article-title":"Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue","volume":"4","year":"2011","journal-title":"Epigenetics Chromatin"},{"key":"key\n\t\t\t\t20171013013208_DMU033C56","first-page":"704","article-title":"Quantitative methylation analysis of developmentally important genes in human pregnancy losses after ART and spontaneous conception","volume":"16","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20171013013208_DMU033C57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/humrep\/des358","article-title":"Aberrant DNA methylation of imprinted loci in human spontaneous abortions after assisted reproduction techniques and natural conception","volume":"28","year":"2013","journal-title":"Hum Reprod"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/20\/6\/840\/17055820\/dmu033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T18:05:14Z","timestamp":1565546714000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humupd\/article\/20\/6\/840\/2952650\/A-systematic-review-and-metaanalysis-of-DNA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,24]]},"references-count":57,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,24]]},"published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmu033","relation":{},"ISSN":["1355-4786","1460-2369"],"issn-type":[{"value":"1355-4786","type":"print"},{"value":"1460-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,24]]}}}