{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:30:51Z","timestamp":1793377851369,"version":"4.5.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SACVRDP"},{"name":"South Australian Department of Health and the South Australian Health and Medical Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Reprod. Update"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1093\/humupd\/dmv025","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T19:55:21Z","timestamp":1433966121000},"page":"560-574","source":"Crossref","is-referenced-by-count":289,"title":["Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis"],"prefix":"10.1093","volume":"21","author":[{"given":"Negar","family":"Naderpoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soulmaz","family":"Shorakae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"de Courten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie L.","family":"Misso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J.","family":"Teede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"key":"2015081110283483000_21.5.560.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02157.x"},{"key":"2015081110283483000_21.5.560.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3415"},{"key":"2015081110283483000_21.5.560.3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.4.1555"},{"key":"2015081110283483000_21.5.560.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602293340906"},{"key":"2015081110283483000_21.5.560.5","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/S0020-7292(09)60473-2","article-title":"Role of Metformin in the treatment of polycystic ovarian disease","volume":"107","author":"Batra","year":"2009","journal-title":"Int J Gynecol Obstet"},{"key":"2015081110283483000_21.5.560.6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5694\/mja11.10553","article-title":"Prevalence of polycystic ovary syndrome in a sample of Indigenous women in Darwin, Australia","volume":"196","author":"Boyle","year":"2012","journal-title":"Med J Aust"},{"key":"2015081110283483000_21.5.560.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04554-5"},{"key":"2015081110283483000_21.5.560.8","doi-asserted-by":"crossref","unstructured":"Costello M , Shrestha B , Eden J , Sjoblom P , Johnson N . Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev 2007;Cd005552.","DOI":"10.1002\/14651858.CD005552.pub2"},{"key":"2015081110283483000_21.5.560.9","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.583957"},{"key":"2015081110283483000_21.5.560.10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-1-200007040-00016"},{"key":"2015081110283483000_21.5.560.11","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K656"},{"key":"2015081110283483000_21.5.560.12","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1299"},{"key":"2015081110283483000_21.5.560.13","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0733"},{"key":"2015081110283483000_21.5.560.14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2385"},{"key":"2015081110283483000_21.5.560.15","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.681636"},{"key":"2015081110283483000_21.5.560.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.02051.x"},{"key":"2015081110283483000_21.5.560.17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2250"},{"key":"2015081110283483000_21.5.560.18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3886"},{"key":"2015081110283483000_21.5.560.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.02.104"},{"key":"2015081110283483000_21.5.560.20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0461"},{"key":"2015081110283483000_21.5.560.21","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2014.966385"},{"key":"2015081110283483000_21.5.560.22","doi-asserted-by":"publisher","DOI":"10.1080\/09513590802288242"},{"key":"2015081110283483000_21.5.560.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.078"},{"key":"2015081110283483000_21.5.560.24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"key":"2015081110283483000_21.5.560.25","article-title":"Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study","volume":"95","author":"Ladson","year":"2011","journal-title":"Fertil Steril"},{"key":"2015081110283483000_21.5.560.26","article-title":"The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study","volume":"95","author":"Ladson","year":"2011","journal-title":"Fertil Steril"},{"key":"2015081110283483000_21.5.560.27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063971"},{"key":"2015081110283483000_21.5.560.28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2350"},{"key":"2015081110283483000_21.5.560.29","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms030"},{"key":"2015081110283483000_21.5.560.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01053.x"},{"key":"2015081110283483000_21.5.560.31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100379"},{"key":"2015081110283483000_21.5.560.32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7421.951"},{"key":"2015081110283483000_21.5.560.33","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep399"},{"key":"2015081110283483000_21.5.560.34","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0618"},{"key":"2015081110283483000_21.5.560.35","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms036"},{"key":"2015081110283483000_21.5.560.36","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.139"},{"key":"2015081110283483000_21.5.560.37","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm026"},{"key":"2015081110283483000_21.5.560.38","doi-asserted-by":"crossref","unstructured":"Moran LJ , Hutchison SK , Norman RJ , Teede HJ . Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev 2011;CD007506.","DOI":"10.1002\/14651858.CD007506.pub3"},{"key":"2015081110283483000_21.5.560.39","unstructured":"NEbw panel. NIH Evidence based workshop on Polycystic Ovary Syndrome. 2012."},{"key":"2015081110283483000_21.5.560.40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0707092"},{"key":"2015081110283483000_21.5.560.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"2015081110283483000_21.5.560.42","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn043"},{"key":"2015081110283483000_21.5.560.43","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1237705"},{"key":"2015081110283483000_21.5.560.44","doi-asserted-by":"publisher","DOI":"10.3109\/09513590903215581"},{"key":"2015081110283483000_21.5.560.45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03369.x"},{"key":"2015081110283483000_21.5.560.46","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2767"},{"key":"2015081110283483000_21.5.560.47","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0097-z"},{"key":"2015081110283483000_21.5.560.48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0772"},{"key":"2015081110283483000_21.5.560.49","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"2015081110283483000_21.5.560.50","doi-asserted-by":"publisher","DOI":"10.1159\/000335253"},{"key":"2015081110283483000_21.5.560.51","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des463"},{"key":"2015081110283483000_21.5.560.52","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei311"},{"key":"2015081110283483000_21.5.560.53","first-page":"CD003053","article-title":"Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"5","author":"Tang","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2015081110283483000_21.5.560.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.08.001"},{"key":"2015081110283483000_21.5.560.55","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-41"},{"key":"2015081110283483000_21.5.560.56","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10915"},{"key":"2015081110283483000_21.5.560.57","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20213"},{"key":"2015081110283483000_21.5.560.58","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2978"},{"key":"2015081110283483000_21.5.560.59","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh347"},{"key":"2015081110283483000_21.5.560.60","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110386"},{"key":"2015081110283483000_21.5.560.61","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.736557"},{"key":"2015081110283483000_21.5.560.62","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.705368"},{"key":"2015081110283483000_21.5.560.63","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des232"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/21\/5\/560\/17158390\/dmv025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T03:06:45Z","timestamp":1503457605000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humupd\/article-lookup\/doi\/10.1093\/humupd\/dmv025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,8,11]]},"published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1093\/humupd\/dmv025"],"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmv025","relation":{},"ISSN":["1355-4786","1460-2369"],"issn-type":[{"value":"1355-4786","type":"print"},{"value":"1460-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,9]]}}}