{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:45:09Z","timestamp":1792817109645,"version":"4.5.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003358","name":"GEDEON-RICHTER","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>A worldwide increase in the prevalence of obesity has been observed in the past three decades, particularly in women of reproductive age. Female obesity has been clearly associated with impaired spontaneous fertility, as well as adverse pregnancy outcomes. Increasing evidence in the literature shows that obesity also contributes to adverse clinical outcomes following in vitro fertilization (IVF) procedures. However, the heterogeneity of the available studies in terms of populations, group definition and outcomes prevents drawing firm conclusions. A previous meta-analysis published in 2011 identified a marginal but significant negative effect of increased female body mass index (BMI) on IVF results, but numerous studies have been published since then, including large cohort studies from national registries, highlighting the need for an updated review and meta-analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVE AND RATIONALE<\/jats:title>\n                  <jats:p>Our systematic review and meta-analysis of the available literature aims to evaluate the association of female obesity with the probability of live birth following IVF. Subgroup analyses according to ovulatory status, oocyte origin, fresh or frozen-embryo transfer and cycle rank were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SEARCH METHODS<\/jats:title>\n                  <jats:p>A systematic review was performed using the following key words: (\u2018obesity\u2019, \u2018body mass index\u2019, \u2018live birth\u2019, \u2018IVF\u2019, \u2018ICSI\u2019). Searches were conducted in MEDLINE, EMBASE, Cochrane Library, Eudract and clinicaltrial.gov from 01 January 2007 to 30 November 2017. Study selection was based on title and abstract. Full texts of potentially relevant articles were retrieved and assessed for inclusion by two reviewers. Subsequently, quality was assessed using the Newcastle-Ottawa Quality Assessment Scales for patient selection, comparability and assessment of outcomes. Two independent reviewers carried out study selection and data extraction according to Cochrane methods. Random-effect meta-analysis was performed using Review Manager software on all data (overall analysis), followed by subgroup analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OUTCOMES<\/jats:title>\n                  <jats:p>A total of 21 studies were included in the meta-analysis. A decreased probability of live birth following IVF was observed in obese (BMI \u2265 30 kg\/m2) women when compared with normal weight (BMI 18.5\u201324.9 kg\/m2) women: risk ratio (RR) (95% CI) 0.85 (0.82\u20130.87). Subgroups analyses demonstrated that prognosis was poorer when obesity was associated with polycystic ovary syndrome, while the oocyte origin (donor or non-donor) did not modify the overall interpretation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS<\/jats:title>\n                  <jats:p>Our meta-analysis clearly demonstrates that female obesity negatively and significantly impacts live birth rates following IVF. Whether weight loss can reverse this deleterious effect through lifestyle modifications or bariatric surgery should be further evaluated.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humupd\/dmz011","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T15:35:06Z","timestamp":1551368106000},"page":"439-451","source":"Crossref","is-referenced-by-count":360,"title":["Female obesity is negatively associated with live birth rate following IVF: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"25","author":[{"given":"Nathalie","family":"Sermondade","sequence":"first","affiliation":[{"name":"Service de Biologie de la Reproduction, H\u00f4pital Tenon, H\u00f4pitaux Universitaires Est Parisien, Assistance Publique\u2014H\u00f4pitaux de Paris, PARIS, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Huberlant","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Gyn\u00e9cologie Obst\u00e9trique et M\u00e9decine de la Reproduction, CHU Car\u00e9meau, NIMES, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bourhis-Lefebvre","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine de la Reproduction, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisangela","family":"Arbo","sequence":"additional","affiliation":[{"name":"Gedeon Richter France, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Gallot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine de la Reproduction et Pr\u00e9servation de la Fertilit\u00e9, H\u00f4pital Antoine B\u00e9cl\u00e8re, Assistance Publique\u2014H\u00f4pitaux de Paris, Clamart, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Colombani","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine de la Reproduction, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-7709","authenticated-orcid":false,"given":"Thomas","family":"Fr\u00e9our","sequence":"additional","affiliation":[{"name":"Service de biologie et m\u00e9decine de la reproduction, CHU de Nantes, NANTES 44093, France\u2014Facult\u00e9 de m\u00e9decine, Universit\u00e9 de Nantes, France\u2014INSERM UMR1064, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"2019070109124112900_dmz011C1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1001\/archinte.166.19.2081","article-title":"Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women","volume":"166","author":"Alvarez-Blasco","year":"2006","journal-title":"Arch Intern Med"},{"key":"2019070109124112900_dmz011C2","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.fertnstert.2015.08.018","article-title":"Obesity and reproduction: a committee opinion","volume":"104","author":"ASRM (American Society for Reproductive Medicine)","year":"2015","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C3","doi-asserted-by":"crossref","first-page":"163.e1","DOI":"10.1016\/j.ajog.2014.03.035","article-title":"Effect of body mass index on in vitro fertilization outcomes in women with polycystic ovary syndrome","volume":"211","author":"Bailey","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2019070109124112900_dmz011C4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J Intern Med"},{"key":"2019070109124112900_dmz011C6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.fertnstert.2008.12.032","article-title":"Female obesity impairs in vitro fertilization outcome without affecting embryo quality","volume":"93","author":"Bellver","year":"2010","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C7","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.fertnstert.2011.03.021","article-title":"Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome","volume":"95","author":"Bellver","year":"2011","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C8","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.fertnstert.2013.06.001","article-title":"Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors","volume":"100","author":"Bellver","year":"2013","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/humupd\/dmx027","article-title":"How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese? A systematic review and meta-analysis of the evidence","volume":"23","author":"Best","year":"2017","journal-title":"Hum Reprod Update"},{"key":"2019070109124112900_dmz011C10","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/hec.3383","article-title":"Measuring socioeconomic inequality in obesity: looking beyond the obesity threshold","volume":"26","author":"Bilger","year":"2017","journal-title":"Health Econ"},{"key":"2019070109124112900_dmz011C11","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/AOG.0000000000000677","article-title":"Weight loss in obese pregnant women and risk for adverse perinatal outcomes","volume":"125","author":"Bogaerts","year":"2015","journal-title":"Obstet Gynecol"},{"key":"2019070109124112900_dmz011C12","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.fertnstert.2017.01.017","article-title":"Obesity and female infertility: potential mediators of obesity\u2019s impact","volume":"107","author":"Broughton","year":"2017","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C13","doi-asserted-by":"crossref","first-page":"k1767","DOI":"10.1136\/bmj.k1767","article-title":"Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank","volume":"361","author":"Carreras-Torres","year":"2018","journal-title":"BMJ"},{"key":"2019070109124112900_dmz011C14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/humupd\/dmv057","article-title":"Leptin and its potential interest in assisted reproduction cycles","volume":"22","author":"Catteau","year":"2016","journal-title":"Hum Reprod Update"},{"key":"2019070109124112900_dmz011C15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fertnstert.2012.04.012","article-title":"Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction","volume":"98","author":"Chavarro","year":"2012","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/oby.20590","article-title":"Bariatric surgery influences the number and quality of oocytes in patients submitted to assisted reproduction techniques","volume":"22","author":"Christofolini","year":"2014","journal-title":"Obesity"},{"key":"2019070109124112900_dmz011C17","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s10815-015-0515-1","article-title":"Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization","volume":"32","author":"Comstock","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"2019070109124112900_dmz011C18","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1093\/humrep\/dex235","article-title":"Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial","volume":"32","author":"Einarsson","year":"2017","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C19","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/humrep\/dep458","article-title":"Lifestyle-related factors and access to medically assisted reproduction","volume":"25","author":"ESHRE Task Force on Ethics and Law, including","year":"2010","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(10)62037-5","article-title":"National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9\u00b71 million participants","volume":"377","author":"Finucane","year":"2011","journal-title":"Lancet"},{"key":"2019070109124112900_dmz011C21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999\u20132010","volume":"307","author":"Flegal","year":"2012","journal-title":"JAMA"},{"key":"2019070109124112900_dmz011C22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejogrb.2014.07.015","article-title":"Maternal and neonatal outcomes in women undergoing bariatric surgery: a systelmatic review and meta-analysis","volume":"181","author":"Galazis","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2019070109124112900_dmz011C23","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00394-014-0746-4","article-title":"Overweight and obesity in 16 European countries","volume":"54","author":"Gallus","year":"2015","journal-title":"Eur J Nutr"},{"key":"2019070109124112900_dmz011C24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/humrep\/del400","article-title":"Obesity and time to pregnancy","volume":"22","author":"Gesink Law","year":"2007","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.fertnstert.2014.11.029","article-title":"Association of body mass index with embryonic aneuploidy","volume":"103","author":"Goldman","year":"2015","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/AOG.0000000000000667","article-title":"Factors associated with second- trimester pregnancy loss in women with normal uterine anatomy undergoing in vitro fertilization","volume":"125","author":"Hawkins Bressler","year":"2015","journal-title":"Obstet Gynecol"},{"key":"2019070109124112900_dmz011C27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"2019070109124112900_dmz011C28","doi-asserted-by":"crossref","first-page":"929251","DOI":"10.5402\/2011\/929251","article-title":"Body mass index impacts in vitro fertilization stimulation","volume":"2011","author":"Hill","year":"2011","journal-title":"ISRN Obstet Gynecol"},{"key":"2019070109124112900_dmz011C29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.fertnstert.2017.08.024","article-title":"Neutral effect of body mass index on implantation rate after frozen-thawed blastocyst transfer","volume":"108","author":"Insogna","year":"2017","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C30","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1056\/NEJMoa1405789","article-title":"Outcomes of pregnancy after bariatric surgery","volume":"372","author":"Johansson","year":"2015","journal-title":"N Engl J Med"},{"key":"2019070109124112900_dmz011C32","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.fertnstert.2011.01.154","article-title":"Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization","volume":"95","author":"Jungheim","year":"2011","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ajog.2010.06.043","article-title":"Current knowledge of obesity\u2019s effects in the pre- and periconceptional periods and avenues for future research","volume":"203","author":"Jungheim","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"2019070109124112900_dmz011C34","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1093\/humrep\/det292","article-title":"IVF outcomes in obese donor oocyte recipients: a systematic review and meta-analysis","volume":"28","author":"Jungheim","year":"2013","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C35","doi-asserted-by":"crossref","first-page":"j4511","DOI":"10.1136\/bmj.j4511","article-title":"Obesity and gynaecological and obstetric conditions: umbrella review of the literature","volume":"359","author":"Kalliala","year":"2017","journal-title":"BMJ"},{"key":"2019070109124112900_dmz011C36","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.fertnstert.2016.08.028","article-title":"Extremities of body mass index and their association with pregnancy outcomes in women undergoing in vitro fertilization in the United States","volume":"106","author":"Kawwass","year":"2016","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/humrep\/der416","article-title":"Complications and outcome of assisted reproduction technologies in overweight and obese women","volume":"27","author":"Koning","year":"2012","journal-title":"Human Reprod"},{"key":"2019070109124112900_dmz011C38","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/jc.2016-1659","article-title":"Benefit of delayed fertility therapy with preconception weight loss over immediate therapy in obese women With PCOS","volume":"101","author":"Legro","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2019070109124112900_dmz011C39","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1055\/s-0043-107617","article-title":"High leptin level attenuates embryo development in overweight\/obese infertile women by inhibiting proliferation and promotes apoptosis in granule cell","volume":"49","author":"Lin","year":"2017","journal-title":"Horm Metab Res"},{"key":"2019070109124112900_dmz011C40","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.fertnstert.2017.02.114","article-title":"Adverse effects of female obesity and interaction with race on reproductive potential","volume":"107","author":"Luke","year":"2017","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/humrep\/deq306","article-title":"Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates","volume":"26","author":"Luke","year":"2011","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/humupd\/dmm017","article-title":"Effect of overweight and obesity on assisted reproductive technology\u2014a systematic review","volume":"13","author":"Maheshwari","year":"2007","journal-title":"Hum Reprod Update"},{"key":"2019070109124112900_dmz011C43","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.fertnstert.2007.10.077","article-title":"Effects of polycystic ovarian syndrome on in vitro fertilization-embryo transfer outcomes are influenced by body mass index","volume":"90","author":"McCormick","year":"2008","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C44","doi-asserted-by":"crossref","first-page":"i5735","DOI":"10.1136\/bmj.i5735","article-title":"Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women","volume":"355","author":"McLernon","year":"2016","journal-title":"BMJ"},{"key":"2019070109124112900_dmz011C45","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ehb.2016.05.004","article-title":"Disentangling effects of socioeconomic status on obesity: a cross-sectional study of the Spanish adult population","volume":"22","author":"Merino Ventosa","year":"2016","journal-title":"Econ Hum Biol"},{"key":"2019070109124112900_dmz011C46","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1196\/annals.1434.000","article-title":"Reproductive endocrinology and clinical aspects of obesity in women","volume":"1127","author":"Metwally","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"2019070109124112900_dmz011C47","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1007\/s11695-017-2614-9","article-title":"Does bariatric surgery improve assisted reproductive technology outcomes in obese infertile women?","volume":"27","author":"Milone","year":"2017","journal-title":"Obes Surg"},{"key":"2019070109124112900_dmz011C49","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tem.2014.12.003","article-title":"Metabolic risk in PCOS: phenotype and adiposity impact","volume":"26","author":"Moran","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"2019070109124112900_dmz011C50","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.rbmo.2018.01.002","article-title":"Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis","volume":"36","author":"Mushtaq","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"2019070109124112900_dmz011C51","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1056\/NEJMoa1505297","article-title":"Randomized trial of a lifestyle program in obese infertile women","volume":"374","author":"Mutsaerts","year":"2016","journal-title":"N Engl J Med"},{"key":"2019070109124112900_dmz011C52","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"2019070109124112900_dmz011C53","volume-title":"Fertility: assessment and treatment for people with fertility problems","author":"NICE (National Institute for Health and Care Excellence)","year":"2013"},{"key":"2019070109124112900_dmz011C54","first-page":"155","article-title":"Impact of body mass index (BMI) and age on the outcome of the IVF process","volume":"32","author":"Petanovski","year":"2011","journal-title":"Prilozi"},{"key":"2019070109124112900_dmz011C55","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.rbmo.2011.06.010","article-title":"Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples","volume":"23","author":"Pinborg","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"2019070109124112900_dmz011C56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.fertnstert.2015.11.008","article-title":"Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008\u20132010 Society for Assisted Reproductive Technology registry","volume":"105","author":"Provost","year":"2016","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C57","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2015.10.015","article-title":"Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor\/recipient cycles from the 2008\u20132010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry","volume":"105","author":"Provost","year":"2016","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C58","volume-title":"Ovarian stimulation in assisted reproduction","author":"RANZCOG (The Royal Australian and New Zealand College of Obstetricians and Gynaecologists)","year":"2014"},{"key":"2019070109124112900_dmz011C80","unstructured":"Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014."},{"key":"2019070109124112900_dmz011C59","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/humrep\/dew048","article-title":"Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy","volume":"31","author":"Rhee","year":"2016","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C60","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00001648-200203000-00013","article-title":"Physical activity, body mass index, and ovulatory disorder infertility","volume":"13","author":"Rich-Edwards","year":"2002","journal-title":"Epidemiology"},{"key":"2019070109124112900_dmz011C61","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.rbmo.2011.06.018","article-title":"Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis","volume":"23","author":"Rittenberg","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"2019070109124112900_dmz011C62","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10815-017-0883-9","article-title":"Morbid obesity and pregnancy outcomes after single blastocyst transfer: a retrospective, North American study","volume":"34","author":"Russo","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"2019070109124112900_dmz011C63","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.fertnstert.2014.10.048","article-title":"Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization","volume":"103","author":"Schliep","year":"2015","journal-title":"Fertil Steril"},{"key":"2019070109124112900_dmz011C64","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5005\/jp-journals-10016-1082","article-title":"Prospective study of effect of body weight on in vitro fertilization outcome in reproductive age group","volume":"5","author":"Sharma","year":"2014","journal-title":"Int J Infertil Fetal Med"},{"key":"2019070109124112900_dmz011C65","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejogrb.2014.08.004","article-title":"Clinical predictive criteria associated with live birth following elective single embryo transfer","volume":"181","author":"Sifer","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2019070109124112900_dmz011C67","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/humrep\/den188","article-title":"Body mass index: impact on IVF success appears age-related","volume":"23","author":"Sneed","year":"2008","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C68","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"2019070109124112900_dmz011C69","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"2019070109124112900_dmz011C70","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13048-014-0116-0","article-title":"Does bariatric surgery improve ovarian stimulation characteristics, oocyte yield, or embryo quality?","volume":"7","author":"Tsur","year":"2014","journal-title":"J Ovarian Res"},{"key":"2019070109124112900_dmz011C71","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1093\/humrep\/des350","article-title":"BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality","volume":"27","author":"Valckx","year":"2012","journal-title":"Hum Reprod"},{"key":"2019070109124112900_dmz011C72","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/s12889-016-3182-y","article-title":"Smoking and socio-demographic correlates of BMI","volume":"16","author":"Wang","year":"2016","journal-title":"BMC Public Health"},{"key":"2019070109124112900_dmz011C73","author":"WHO"},{"key":"2019070109124112900_dmz011C74","first-page":"8","article-title":"Obesity: preventing and managing the global epidemic: Report of a WHO consultation","volume":"894","author":"WHO","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"2019070109124112900_dmz011C75","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1210\/jc.2007-1834","article-title":"Impact of obesity on the risk for polycystic ovary syndrome","volume":"93","author":"Yildiz","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2019070109124112900_dmz011C76","doi-asserted-by":"crossref","first-page":"e0167193","DOI":"10.1371\/journal.pone.0167193","article-title":"Four decades of obesity trends among non-hispanic whites and blacks in the united states: analyzing the influences of educational inequalities in obesity and population improvements in education","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS One"},{"key":"2019070109124112900_dmz011C77","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1479-828X.2012.01453.x","article-title":"Does obesity really matter? The impact of BMI on embryo quality and pregnancy outcomes after IVF in women aged \u226438 years","volume":"52","author":"Zander-Fox","year":"2012","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2019070109124112900_dmz011C78","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/09513590.2015.1014785","article-title":"Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF","volume":"31","author":"Zhang","year":"2015","journal-title":"Gynecol Endocrinol"},{"key":"2019070109124112900_dmz011C79","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/09513591003632100","article-title":"Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women","volume":"26","author":"Zhang","year":"2010","journal-title":"Gynecol Endocrinol"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/25\/4\/439\/28888773\/dmz011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T09:13:06Z","timestamp":1561972386000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humupd\/article\/25\/4\/439\/5426458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,4]]},"references-count":76,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,3,4]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmz011","relation":{},"ISSN":["1355-4786","1460-2369"],"issn-type":[{"value":"1355-4786","type":"print"},{"value":"1460-2369","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,3,4]]}}}