{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:47:52Z","timestamp":1790682472182,"version":"4.1.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01-DK099485"],"award-info":[{"award-number":["K01-DK099485"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03-DK114545"],"award-info":[{"award-number":["R03-DK114545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK111856"],"award-info":[{"award-number":["R01-DK111856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL130938"],"award-info":[{"award-number":["R01-HL130938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL080396"],"award-info":[{"award-number":["R01-HL080396"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011684","name":"Crohn's and Colitis Foundation","doi-asserted-by":"publisher","award":["276536"],"award-info":[{"award-number":["276536"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011684","name":"Crohn's and Colitis Foundation","doi-asserted-by":"publisher","award":["601121"],"award-info":[{"award-number":["601121"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The mucus gel layer (MGL) lining the colon is integral to exclusion of bacteria and maintaining intestinal homeostasis in health and disease. Some MGL defects allowing bacteria to directly contact the colonic surface are commonly observed in ulcerative colitis (UC). The major macromolecular component of the colonic MGL is the secreted gel-forming mucin MUC2, whose expression is essential for homeostasis in health. In UC, another gel-forming mucin, MUC5AC, is induced. In mice, Muc5ac is protective during intestinal helminth infection. Here we tested the expression and functional role of MUC5AC\/Muc5ac in UC biopsies and murine colitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We measured MUC5AC\/Muc5ac expression in UC biopsies and in dextran sulfate sodium (DSS) colitis. We performed DSS colitis in mice deficient in Muc5ac (Muc5ac-\/-) to model the potential functional role of Muc5ac in colitis. To assess MGL integrity, we quantified bacterial-epithelial interaction and translocation to mesenteric lymph nodes. Antibiotic treatment and 16S rRNA gene sequencing were performed to directly investigate the role of bacteria in murine colitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Colonic MUC5AC\/Muc5ac mRNA expression increased significantly in active UC and murine colitis. Muc5ac-\/- mice experienced worsened injury and inflammation in DSS colitis compared with control mice. This result was associated with increased bacterial-epithelial contact and translocation to the mesenteric lymph nodes. However, no change in microbial abundance or community composition was noted. Antibiotic treatment normalized colitis severity in Muc5ac-\/- mice to that of antibiotic-treated control mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MUC5AC\/Muc5ac induction in the acutely inflamed colon controls injury by reducing bacterial breach of the MGL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izaa064","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:17:53Z","timestamp":1589008673000},"page":"1353-1367","source":"Crossref","is-referenced-by-count":45,"title":["Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis"],"prefix":"10.1093","volume":"26","author":[{"given":"Kristine E","family":"Olli","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"School of Medicine, Conway Institute, University College Dublin , Belfield, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm B","family":"Collins","sequence":"additional","affiliation":[{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children\u2019s Hospital Colorado , Aurora, Colorado, USA"},{"name":"School of Biomolecular and Biomedical Science, University College Dublin , Belfield, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin N","family":"McNamee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University , County Kildare, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jedlicka","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen C","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E","family":"Gerich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ir","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine , Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5653-9003","authenticated-orcid":false,"given":"Carol M","family":"Aherne","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"Mucosal Inflammation Program, University of Colorado School of Medicine , Aurora, Colorado, USA"},{"name":"School of Medicine, Conway Institute, University College Dublin , Belfield, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"2023112513150738200_CIT0001","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrgastro.2013.35","article-title":"The gastrointestinal mucus system in health and disease","volume":"10","author":"Johansson","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"2023112513150738200_CIT0002","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev-cellbio-100617-062818","article-title":"Mucins and their role in shaping the functions of mucus barriers","volume":"34","author":"Wagner","year":"2018","journal-title":"Annu Rev Cell Dev Biol."},{"key":"2023112513150738200_CIT0003","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol Rev."},{"key":"2023112513150738200_CIT0004","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/0016-5085(94)90537-1","article-title":"Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin","volume":"107","author":"Tytgat","year":"1994","journal-title":"Gastroenterology."},{"key":"2023112513150738200_CIT0005","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1073\/pnas.1006451107","article-title":"The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions","volume":"108","author":"Johansson","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"key":"2023112513150738200_CIT0006","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1126\/science.1069094","article-title":"Colorectal cancer in mice genetically deficient in the mucin Muc2","volume":"295","author":"Velcich","year":"2002","journal-title":"Science."},{"key":"2023112513150738200_CIT0007","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology."},{"key":"2023112513150738200_CIT0008","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/gut.2006.098160","article-title":"Comparative study of the intestinal mucus barrier in normal and inflamed colon","volume":"56","author":"Swidsinski","year":"2007","journal-title":"Gut."},{"key":"2023112513150738200_CIT0009","first-page":"832","article-title":"Proceedings: changes in human colonic mucus in ulcerative colitis","volume":"16","author":"Fraser","year":"1975","journal-title":"Gut."},{"key":"2023112513150738200_CIT0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/gut.35.3.353","article-title":"Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis","volume":"35","author":"Pullan","year":"1994","journal-title":"Gut."},{"key":"2023112513150738200_CIT0011","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1742-1241.2007.01665.x","article-title":"Thickness and continuity of the adherent colonic mucus barrier in active and quiescent ulcerative colitis and Crohn\u2019s disease","volume":"62","author":"Strugala","year":"2008","journal-title":"Int J Clin Pract."},{"key":"2023112513150738200_CIT0012","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","article-title":"Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis","volume":"63","author":"Johansson","year":"2014","journal-title":"Gut."},{"key":"2023112513150738200_CIT0013","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/gut.38.4.554","article-title":"MUC2 is the prominent colonic mucin expressed in ulcerative colitis","volume":"38","author":"Tytgat","year":"1996","journal-title":"Gut."},{"key":"2023112513150738200_CIT0014","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/44.10.8813081","article-title":"Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues","volume":"44","author":"Weiss","year":"1996","journal-title":"J Histochem Cytochem."},{"key":"2023112513150738200_CIT0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<304::AID-PATH375>3.0.CO;2-A","article-title":"Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn\u2019s disease increases detectability of the MUC2 protein core","volume":"188","author":"Hanski","year":"1999","journal-title":"J Pathol."},{"key":"2023112513150738200_CIT0016","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/ecco-jcc\/jjx139","article-title":"Transcriptomic landscape of treatment-na\u00efve ulcerative colitis","volume":"12","author":"Taman","year":"2018","journal-title":"J Crohns Colitis."},{"key":"2023112513150738200_CIT0017","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/bbrc.1996.1039","article-title":"Quantitative analysis of MUC2 synthesis in ulcerative colitis","volume":"224","author":"Tytgat","year":"1996","journal-title":"Biochem Biophys Res Commun."},{"key":"2023112513150738200_CIT0018","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1097\/MIB.0000000000001246","article-title":"Genetic and transcriptomic bases of intestinal epithelial barrier dysfunction in inflammatory bowel disease","volume":"23","author":"Vancamelbeke","year":"2017","journal-title":"Inflamm Bowel Dis."},{"key":"2023112513150738200_CIT0019","doi-asserted-by":"crossref","first-page":"7343","DOI":"10.1038\/srep07343","article-title":"Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases","volume":"4","author":"Hensel","year":"2014","journal-title":"Sci Rep."},{"key":"2023112513150738200_CIT0020","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00005176-200405000-00006","article-title":"Colonic expression of MUC2, MUC5AC, and TFF1 in inflammatory bowel disease in children","volume":"38","author":"Shaoul","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"2023112513150738200_CIT0021","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/gut.44.3.387","article-title":"Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis","volume":"44","author":"Van Klinken","year":"1999","journal-title":"Gut."},{"key":"2023112513150738200_CIT0022","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/BF00702345","article-title":"Colonic mucins in ulcerative colitis: evidence for loss of sulfation","volume":"13","author":"Corfield","year":"1996","journal-title":"Glycoconj J."},{"key":"2023112513150738200_CIT0023","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2018-317571","article-title":"Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis","author":"van der","year":"2019","journal-title":"Gut."},{"key":"2023112513150738200_CIT0024","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/ijc.22865","article-title":"Abnormal expression of M1\/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer","volume":"121","author":"Forgue-Lafitte","year":"2007","journal-title":"Int J Cancer."},{"key":"2023112513150738200_CIT0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.crohns.2007.06.006","article-title":"Aberrant gastric apomucin expression in ulcerative colitis and associated neoplasia","volume":"1","author":"Borralho","year":"2007","journal-title":"J Crohns Colitis."},{"key":"2023112513150738200_CIT0026","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1084\/jem.20102057","article-title":"Muc5ac: a critical component mediating the rejection of enteric nematodes","volume":"208","author":"Hasnain","year":"2011","journal-title":"J Exp Med."},{"key":"2023112513150738200_CIT0027","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121521","article-title":"Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation","volume":"3","author":"Aherne","year":"2018","journal-title":"JCI Insight."},{"key":"2023112513150738200_CIT0028","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/gutjnl-2011-300012","article-title":"Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis","volume":"61","author":"Aherne","year":"2012","journal-title":"Gut."},{"key":"2023112513150738200_CIT0029","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/ibd.21763","article-title":"Dextran sodium sulfate inhibition of real-time polymerase chain reaction amplification: a poly-A purification solution","volume":"18","author":"Kerr","year":"2012","journal-title":"Inflamm Bowel Dis."},{"key":"2023112513150738200_CIT0030","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/mi.2015.22","article-title":"Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis","volume":"8","author":"Aherne","year":"2015","journal-title":"Mucosal Immunol."},{"key":"2023112513150738200_CIT0031","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/mi.2012.134","article-title":"Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function","volume":"6","author":"Collins","year":"2013","journal-title":"Mucosal Immunol."},{"key":"2023112513150738200_CIT0032","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/mi.2009.132","article-title":"Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis","volume":"3","author":"Hill","year":"2010","journal-title":"Mucosal Immunol."},{"key":"2023112513150738200_CIT0033","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nrmicro2540","article-title":"Unravelling the effects of the environment and host genotype on the gut microbiome","volume":"9","author":"Spor","year":"2011","journal-title":"Nat Rev Microbiol."},{"key":"2023112513150738200_CIT0034","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods."},{"key":"2023112513150738200_CIT0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gr.8.3.186","article-title":"Base-calling of automated sequencer traces using phred. II. error probabilities","volume":"8","author":"Ewing","year":"1998","journal-title":"Genome Res."},{"key":"2023112513150738200_CIT0036","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics."},{"key":"2023112513150738200_CIT0037","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/bioinformatics\/bts252","article-title":"SINA: accurate high-throughput multiple sequence alignment of ribosomal RNA genes","volume":"28","author":"Pruesse","year":"2012","journal-title":"Bioinformatics."},{"key":"2023112513150738200_CIT0038","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2023112513150738200_CIT0039","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/bioinformatics\/btt526","article-title":"Explicet: graphical user interface software for metadata-driven management, analysis and visualization of microbiome data","volume":"29","author":"Robertson","year":"2013","journal-title":"Bioinformatics."},{"key":"2023112513150738200_CIT0040","doi-asserted-by":"crossref","first-page":"7948","DOI":"10.1039\/C5AY90053K","article-title":"Using the Grubbs and Cochran tests to identify outliers","volume":"7","author":"Analytical Methods Committee","year":"2015","journal-title":"Anal Methods."},{"key":"2023112513150738200_CIT0041","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3892\/or.2010.869","article-title":"Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice","volume":"24","author":"Araki","year":"2010","journal-title":"Oncol Rep."},{"key":"2023112513150738200_CIT0042","doi-asserted-by":"crossref","first-page":"e6073","DOI":"10.1371\/journal.pone.0006073","article-title":"Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis","volume":"4","author":"Yan","year":"2009","journal-title":"PLoS One."},{"key":"2023112513150738200_CIT0043","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm Bowel Dis."},{"key":"2023112513150738200_CIT0044","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1084\/jem.20160462","article-title":"Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome","volume":"214","author":"Neudecker","year":"2017","journal-title":"J Exp Med."},{"key":"2023112513150738200_CIT0045","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/1751-2980.12540","article-title":"Potential roles of neutrophils in regulating intestinal mucosal inflammation of inflammatory bowel disease","volume":"18","author":"Zhou","year":"2017","journal-title":"J Dig Dis."},{"key":"2023112513150738200_CIT0046","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.4049\/jimmunol.1103746","article-title":"p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation","volume":"189","author":"Conway","year":"2012","journal-title":"J Immunol."},{"key":"2023112513150738200_CIT0047","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.4049\/jimmunol.0900600","article-title":"CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching\/effacing lesion-forming bacterial pathogen","volume":"183","author":"Spehlmann","year":"2009","journal-title":"J Immunol."},{"key":"2023112513150738200_CIT0048","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00248-015-0613-8","article-title":"Antibiotic-induced depletion of murine microbiota induces mild inflammation and changes in toll-like receptor patterns and intestinal motility","volume":"70","author":"Grasa","year":"2015","journal-title":"Microb Ecol."},{"key":"2023112513150738200_CIT0049","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1038\/s41467-018-05336-9","article-title":"Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism","volume":"9","author":"Zarrinpar","year":"2018","journal-title":"Nat Commun."},{"key":"2023112513150738200_CIT0050","doi-asserted-by":"crossref","first-page":"e17996","DOI":"10.1371\/journal.pone.0017996","article-title":"Depletion of murine intestinal microbiota: effects on gut mucosa and 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