{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:21:19Z","timestamp":1775607679588,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-17-1-0556"],"award-info":[{"award-number":["W81XWH-17-1-0556"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-11-2-0133"],"award-info":[{"award-number":["W81XWH-11-2-0133"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cholecystectomy (CCY) is one of the most frequently performed abdominal surgeries. However, the impact of CCY in clinical settings with altered gastrointestinal physiology and anatomy, such as Crohn\u2019s disease (CD), has not been fully characterized. We sought to investigate clinical outcomes, disease severity, and quality of life of CD patients after CCY.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We utilized a prospective, longitudinal registry of consented CD patients followed at a tertiary center. Crohn\u2019s disease patients that had or had not undergone CCY formed the 2 study groups. The absence or presence of gallbladder was confirmed with abdominal CT scans obtained during routine care. Multiyear clinical, biochemical, and histologic data were collected and analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 834 CD patients, 151 (18%) had undergone CCY. History of CCY was associated with higher disease activity (median Harvey-Bradshaw index; P\u2005&amp;lt;\u20050.001), more years with anemia (P\u2005=\u20050.048), lower albumin (P\u2005=\u20050.001), worse quality of life (mean Short Inflammatory Bowel Disease Questionnaire; P\u2005&amp;lt;\u20050.001), chronic abdominal pain (P\u2005&amp;lt;\u20050.001), higher risk for incident colonic dysplasia (P\u2005=\u20050.011), higher rates of annual hospital admissions (P\u2005=\u20050.004), and opioid use (P\u2005&amp;lt;\u20050.001). In multivariate analysis, CCY remained associated with higher disease activity (P\u2005&amp;lt;\u20050.001), lower albumin (P\u2005=\u20050.008), lower quality of life (P\u2005&amp;lt;\u20050.001), and more hospital admissions (P\u2005=\u20050.008), whereas CD patients with diseased ileum had higher risk for colonic dysplasia (P\u2005=\u20050.031).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CCY in CD patients was associated with multiple markers of disease activity and worse quality of life during multiyear follow up. This data suggests that CCY in CD patients may adversely impact the long-term clinical course.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izaa076","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T23:57:12Z","timestamp":1587427032000},"page":"336-343","source":"Crossref","is-referenced-by-count":7,"title":["The Impact of Cholecystectomy on Long-Term Disease Outcomes and Quality of Life in Patients with Crohn\u2019s Disease"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-7301","authenticated-orcid":false,"given":"Filippos","family":"Koutroumpakis","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maham","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Rush University Medical Center , Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaz","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Ramos Rivers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana G","family":"Hashash","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy","family":"Babichenko","sequence":"additional","affiliation":[{"name":"School of Information Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Pittsburgh , Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvi","family":"Nagpal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Keshavarzian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Rush University Medical Center , Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G","family":"Binion","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"2022092610004875700_CIT0001","first-page":"89","article-title":"The first laparoscopic cholecystectomy","volume":"5","author":"Reynolds","year":"2001","journal-title":"JSLS."},{"key":"2022092610004875700_CIT0002","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1007\/s00464-016-5154-9","article-title":"Nineteen-year trends in incidence and indications for laparoscopic cholecystectomy: the NY State experience","volume":"31","author":"Alli","year":"2017","journal-title":"Surg Endosc."},{"key":"2022092610004875700_CIT0003","doi-asserted-by":"crossref","first-page":"52","DOI":"10.14701\/ahbps.2018.22.1.52","article-title":"Clinical patterns of postcholecystectomy syndrome","volume":"22","author":"Shirah","year":"2018","journal-title":"Ann Hepatobiliary Pancreat 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