{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:31:12Z","timestamp":1790202672649,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>First detected in Wuhan, China, the novel 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped RNA beta-coronavirus responsible for an unprecedented, worldwide pandemic caused by COVID-19. Optimal management of immunosuppression in inflammatory bowel disease (IBD) patients with COVID-19 infection currently is based on expert opinion, given the novelty of the infection and the corresponding lack of high-level evidence in patients with immune-mediated conditions. There are limited data regarding IBD patients with COVID-19 and no data regarding early pregnancy in the era of COVID-19. This article describes a patient with acute severe ulcerative colitis (UC) during her first trimester of pregnancy who also has COVID-19. The case presentation is followed by a review of the literature to date on COVID-19 in regard to inflammatory bowel disease and pregnancy, respectively.<\/jats:p>","DOI":"10.1093\/ibd\/izaa109","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T19:02:18Z","timestamp":1589310138000},"page":"971-973","source":"Crossref","is-referenced-by-count":37,"title":["Management of Acute Severe Ulcerative Colitis in a Pregnant Woman With COVID-19 Infection: A Case Report and Review of the Literature"],"prefix":"10.1093","volume":"26","author":[{"given":"Melissa H","family":"Rosen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, NYU Langone Health , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Axelrad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, NYU Langone Health , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hudesman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, NYU Langone Health , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-1723","authenticated-orcid":false,"given":"David T","family":"Rubin","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine Inflammatory Bowel Disease Center , Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, NYU Langone Health , New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"2022092616480520700_CIT0001","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJM199406303302601","article-title":"Cyclosporine in severe ulcerative colitis refractory to steroid therapy","volume":"330","author":"Lichtiger","year":"1994","journal-title":"N Engl J Med."},{"key":"2022092616480520700_CIT0002","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1053\/j.gastro.2018.12.022","article-title":"Inflammatory bowel disease in pregnancy clinical care pathway: a report from the American Gastroenterological Association IBD Parenthood Project Working Group","volume":"156","author":"Mahadevan","year":"2019","journal-title":"Gastroenterology."},{"key":"2022092616480520700_CIT0003","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.annepidem.2014.06.005","article-title":"First-trimester nonsystemic corticosteroid use and the risk of oral clefts in Norway","volume":"24","author":"Skuladottir","year":"2014","journal-title":"Ann Epidemiol."},{"key":"2022092616480520700_CIT0004","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1503\/cmaj.101063","article-title":"Corticosteroid use during pregnancy and risk of orofacial clefts","volume":"183","author":"Hviid","year":"2011","journal-title":"Cmaj."},{"key":"2022092616480520700_CIT0005","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1399-3038.2009.00852.x","article-title":"Effect of dexamethasone on respiratory syncytial virus-induced lung inflammation in children: results of a randomized, placebo controlled clinical trial","volume":"20","author":"Somers","year":"2009","journal-title":"Pediatr Allergy Immunol."},{"key":"2022092616480520700_CIT0006","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jcv.2004.07.006","article-title":"Effects of early corticosteroid treatment on plasma SARS-associated coronavirus RNA concentrations in adult patients","volume":"31","author":"Lee","year":"2004","journal-title":"J Clin Virol."},{"key":"2022092616480520700_CIT0007","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1164\/rccm.201706-1172OC","article-title":"Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome","volume":"197","author":"Arabi","year":"2018","journal-title":"Am J Respir Crit Care Med."},{"key":"2022092616480520700_CIT0008","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(20)30317-2","article-title":"Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury","volume":"395","author":"Russell","year":"2020","journal-title":"Lancet."},{"key":"2022092616480520700_CIT0009","article-title":"International Organization for the Study of Inflammatory Bowel Disease. Management of patients with Crohn\u2019s disease and ulcerative colitis during the COVID-19 pandemic: results of an international meeting","author":"Rubin","year":"2020","journal-title":"Gastroenterology."},{"key":"2022092616480520700_CIT0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2019.12.040","article-title":"Inpatient management of inflammatory bowel disease-related complications","author":"Kaur","year":"2020","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2022092616480520700_CIT0011","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1099\/vir.0.034983-0","article-title":"Cyclosporin A inhibits the replication of diverse coronaviruses","volume":"92","author":"de Wilde","year":"2011","journal-title":"J Gen Virol."},{"key":"2022092616480520700_CIT0012","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000457560","article-title":"Pharmacokinetics of cyclosporin A in 16 newborn infants of renal or cardiac transplant mothers","volume":"20","author":"Claris","year":"1993","journal-title":"Dev Pharmacol Ther."},{"key":"2022092616480520700_CIT0013","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1016\/S0041-1345(97)00458-2","article-title":"Analysis of 629 pregnancy outcomes in transplant recipients treated with Sandimmun","volume":"29","author":"Lamarque","year":"1997","journal-title":"Transplant Proc."},{"key":"2022092616480520700_CIT0014","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ajg.2017.501","article-title":"Long-term safety of in utero exposure to anti-TNF\u03b1 drugs for the treatment of inflammatory bowel disease: results from the Multicenter European TEDDY Study","volume":"113","author":"Chaparro","year":"2018","journal-title":"Am J Gastroenterol."},{"key":"2022092616480520700_CIT0015","article-title":"Lythgoe MP, Middleton P. Ongoing clinical trials for the management of the COVID-19 pandemic. Trends Pharmacol Sci. 2020. pii: S0165-6147(20)30070-5. doi: 10.1016\/j.tips.2020.03.006. 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