{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:02:20Z","timestamp":1771340540538,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We sought to compare the dysplasia detection rate of high-definition white light endoscopy (HDWLE) with that of chromoendoscopy in patients with long-standing inflammatory bowel disease (IBD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a retrospective observational cohort of patients with IBD who underwent surveillance colonoscopy between October 1, 2016 and September 30, 2017. We assessed the association between dysplasia detection and multiple variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 808 unique colonoscopies were performed, of which 150 (18.6%) included chromoendoscopy. Primary sclerosing cholangitis was a comorbid diagnosis in 24.5% of patients. The performing endoscopist was an IBD specialist with 37.1% of patients and had &amp;gt;10 years\u2019 experience with 64.9% of patients. Prior dysplasia had been seen in 245 (30.3%) patients: 102 (68.0%) and 143 (22.0%) among patients who had chromoendoscopy and HDWLE, respectively. Dysplasia in polyps was found in 129 procedures (15.1%). Among patients who had chromoendoscopy and HDWLE, polypoid dysplasia was identified in 50 (33.0%) and 79 (12.0%) patients, respectively, P &amp;lt; 0.01. Dysplasia in random biopsies was found in 39 patients (4.8%): 15 (10%) who had chromoendoscopy and 24 (3.6%) who had HDWLE (P &amp;lt; 0.001). On multivariate analysis, patient and disease characteristics significantly associated with an increased odds for polypoid dysplasia included older age at diagnosis (odds ratio [OR] = 1.3 per 10 years; 95% confidence interval [CI], 1.07-1.60), having an IBD physician endoscopist (OR = 1.6; 95% CI, 1.01-2.67), having an endoscopist with less than 10 years\u2019 experience (OR = 1.8; 95% CI (1.16-2.89), and prior random dysplasia (OR = 4.2; 95% CI (1.93-9.17). Concomitant primary sclerosing cholangitis was significantly associated with random dysplasia (OR = 2.3; 95% CI, 1.02-5.07). After multivariate analysis adjusting for these variables, chromoendoscopy was no more likely to identify dysplasia than was HDWLE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Chromoendoscopy and HDWLE had a similar diagnostic yield for dysplasia detection in patients with chronic IBD-colitis after adjusting for multiple known risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izaa146","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T06:28:29Z","timestamp":1591943309000},"page":"594-602","source":"Crossref","is-referenced-by-count":10,"title":["A 1-Year Cross-sectional Inflammatory Bowel Disease Surveillance Colonoscopy Cohort Comparing High-definition White Light Endoscopy and Chromoendoscopy"],"prefix":"10.1093","volume":"27","author":[{"given":"Nayantara","family":"Coelho-Prabhu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H","family":"Bruining","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A","family":"Faubion","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunanda V","family":"Kane","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B","family":"Kisiel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos A","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell S","family":"Pardi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E","family":"Raffals","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Tremaine","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Fruth","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Scott","family":"Harmsen","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester , Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Edward V","family":"Loftus","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Rochester , Minnesota , 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