{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:22:17Z","timestamp":1787008937818,"version":"build-2736575974"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French Institute of Health"},{"name":"Universit\u00e9 de Paris, and the Investisements d\u2019Avenir","award":["ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR-11-IDEX-0005-02"]}]},{"name":"Laboratoire d\u2019Excellence LABEX INFLAMEX"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ileal pouch-anal anastomosis (IPAA) is the standard of care after total proctocolectomy for ulcerative colitis (UC). However, inflammation often develops in the pouch, leading to acute or recurrent\/chronic pouchitis (R\/CP). MicroRNAs (miRNA) are used as accurate diagnostic and predictive biomarkers in many human diseases, including inflammatory bowel diseases. Therefore, we aimed to identify an miRNA-based biomarker to predict the occurrence of R\/CP in patients with UC after colectomy and IPAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study in 3 tertiary centers in France. We included patients with UC who had undergone IPAA with or without subsequent R\/CP. Paraffin-embedded biopsies collected from the terminal ileum during the proctocolectomy procedure were used for microarray analysis of miRNA expression profiles. Deep neural network\u2013based classifiers were used to identify biomarkers predicting R\/CP using miRNA expression and relevant biological and clinical factors in a discovery cohort of 29 patients. The classification algorithm was tested in an independent validation cohort of 28 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A combination of 11 miRNA expression profiles and 3 biological\/clinical factors predicted the outcome of R\/CP with 88% accuracy (area under the curve\u2005=\u20050.94) in the discovery cohort. The performance of the classification algorithm was confirmed in the validation cohort with 88% accuracy (area under the curve\u2005=\u20050.90). Apoptosis, cytoskeletal regulation by Rho GTPase, and fibroblast growth factor signaling were the most dysregulated targets of the 11 selected miRNAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We developed and validated a computational miRNA-based algorithm for accurately predicting R\/CP in patients with UC after IPAA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izab030","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T02:34:15Z","timestamp":1613874855000},"page":"1653-1660","source":"Crossref","is-referenced-by-count":9,"title":["Computational Learning of microRNA-Based Prediction of Pouchitis Outcome After Restorative Proctocolectomy in Patients With Ulcerative Colitis"],"prefix":"10.1093","volume":"27","author":[{"given":"Ian","family":"Morilla","sequence":"first","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"},{"name":"Universit\u00e9 Sorbonne Paris-Nord, Laboratoire d\u2019Excellence Inflamex , Villetaneuse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Uzzan","sequence":"additional","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"},{"name":"D\u00e9partement de Gastroent\u00e9rologie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Beaujon, Clichy la Garenne , Clichy Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Cazals-Hatem","sequence":"additional","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"},{"name":"Service d\u2019anatomopathologie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Beaujon, Clichy la Garenne , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Colnot","sequence":"additional","affiliation":[{"name":"Service d\u2019anatomopathologie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Beaujon, Clichy la Garenne , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-9727","authenticated-orcid":false,"given":"Yves","family":"Panis","sequence":"additional","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"},{"name":"Service de chirurgie colorectale, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Beaujon, Clichy la Garenne , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nancey","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, Hospices Civils de Lyon , Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Boschetti","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9pato-Gastroent\u00e9rologie, Hospices Civils de Lyon , Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Amiot","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie, H\u00f4pital Henri Mondor , Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Tr\u00e9ton","sequence":"additional","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"},{"name":"D\u00e9partement de Gastroent\u00e9rologie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Beaujon, Clichy la Garenne , Clichy Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-7593","authenticated-orcid":false,"given":"Eric","family":"Ogier-Denis","sequence":"additional","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Daniel","sequence":"additional","affiliation":[{"name":"INSERM U1149, Universit\u00e9 de Paris, Centre de Recherche sur l\u2019inflammation, Team Gut Inflammation , Paris, France"},{"name":"Laboratory of Excellence Labex INFLAMEX , Sorbonne Paris-Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"2022092120224762300_CIT0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.crohns.2014.08.012","article-title":"European evidence based consensus on surgery for ulcerative colitis","volume":"9","author":"\u00d8resland","year":"2015","journal-title":"J Crohns Colitis."},{"key":"2022092120224762300_CIT0002","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0889-8553(05)70175-8","article-title":"Pouch and 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