{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:50:38Z","timestamp":1790805038149,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Prediction of endoscopic postoperative recurrence (POR) and prophylactic treatment based on clinical risk profile have thus far been inconclusive. This study aimed to examine the association between clinical risk profile and the development of endoscopic POR in a Crohn\u2019s disease population without postoperative treatment and to identify individual risk factors of endoscopic POR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Medical records of 142 patients with Crohn\u2019s disease during follow-up after ileocecal or ileocolonic resection without prophylactic treatment at 3 referral centers were reviewed. Endoscopic POR was defined as a modified Rutgeerts score \u2265i2b. Clinical risk profiles were distilled from current guidelines. Both uni- and multivariate logistic regression analysis were used to assess the relationship between risk profiles and endoscopic POR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Endoscopic POR was observed in 68 out of 142 (47.9%) patients. Active smoking postsurgery (odds ratio [OR], 3.01; 95% confidence interval [CI], 1.24-7.34; P\u2005=\u20050.02), a Montreal classification of A3 (OR, 3.05; 95% CI, 1.07-8.69; P\u2005=\u20050.04), and previous bowel resections (OR, 2.58; 95% CI, 1.07-6.22; P\u2005=\u20050.03) were significantly associated with endoscopic POR. No significant association was observed between endoscopic POR and any guideline defined as a high-\/low-risk profile. However, patients with a combination of any 3 or more European Crohns &amp; Colitis Organisation\u2013 (OR, 4.87; 95% CI, 1.30-18.29; P\u2005=\u20050.02) or British Society of Gastroenterology\u2013defined (OR 3.16; 95% CI, 1.05-9.49; P\u2005=\u20050.04) risk factors showed increased odds of developing endoscopic POR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggest that patients with a combination of any 3 or more European Crohns &amp; Colitis Organisation\u2013 or British Society of Gastroenterology\u2013defined risk factors would probably benefit from immediate prophylactic treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izab044","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T10:46:34Z","timestamp":1617101194000},"page":"1-8","source":"Crossref","is-referenced-by-count":43,"title":["Natural History and Risk Stratification of Recurrent Crohn\u2019s Disease After Ileocolonic Resection: A Multicenter Retrospective Cohort Study"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-7220","authenticated-orcid":false,"given":"Vincent","family":"Joustra","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, AGEM University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, AGEM University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aart","family":"Mookhoek","sequence":"additional","affiliation":[{"name":"Department of Pathology, VU University Medical Centre, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne","family":"Buskens","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matic","family":"Ko\u017eelj","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Hindryckx","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Mostafavi","sequence":"additional","affiliation":[{"name":"Biostatistical Unit, Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"D\u2019Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, AGEM University of Amsterdam, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"2022010520142550800_CIT0001","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ajg.2008.168","article-title":"Management of Crohn\u2019s disease in adults","volume":"104","author":"Lichtenstein","year":"2009","journal-title":"Am J Gastroenterol."},{"key":"2022010520142550800_CIT0002","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/j.gastro.2013.07.041","article-title":"Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies","volume":"145","author":"Frolkis","year":"2013","journal-title":"Gastroenterology."},{"key":"2022010520142550800_CIT0003","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/j.gastro.2005.01.010","article-title":"Ornidazole for prophylaxis of postoperative Crohn\u2019s disease recurrence: a randomized, double-blind, placebo-controlled trial","volume":"128","author":"Rutgeerts","year":"2005","journal-title":"Gastroenterology."},{"key":"2022010520142550800_CIT0004","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/bjs.10595","article-title":"Short- and medium-term outcomes following primary ileocaecal resection for Crohn\u2019s disease in two specialist centres","volume":"104","author":"de Buck van Overstraeten","year":"2017","journal-title":"Br J Surg."},{"key":"2022010520142550800_CIT0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/flgastro-2016-100749","article-title":"Postoperative prophylaxis in Crohn\u2019s disease after intestinal resection: a retrospective analysis","volume":"8","author":"O\u2019Connor","year":"2017","journal-title":"Frontline Gastroenterol."},{"key":"2022010520142550800_CIT0006","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0000000000003395","article-title":"Decreasing trends in intestinal resection and re-resection in Crohn\u2019s disease: a nationwide cohort study","author":"Beelen","year":"2021;273:557\u2013563","journal-title":"Ann Surg."},{"key":"2022010520142550800_CIT0007","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","article-title":"3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: Part 2: surgical management and special situations","volume":"11","author":"Gionchetti","year":"2017","journal-title":"J Crohns Colitis."},{"key":"2022010520142550800_CIT0008","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/0016-5085(90)90613-6","article-title":"Predictability of the postoperative course of Crohn\u2019s disease","volume":"99","author":"Rutgeerts","year":"1990","journal-title":"Gastroenterology."},{"key":"2022010520142550800_CIT0009","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/gut.33.3.331","article-title":"Natural course of Crohn\u2019s disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms","volume":"33","author":"Olaison","year":"1992","journal-title":"Gut."},{"key":"2022010520142550800_CIT0010","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"Lamb","year":"2019","journal-title":"Gut."},{"key":"2022010520142550800_CIT0011","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1053\/j.gastro.2016.10.038","article-title":"American Gastroenterological Association Institute Guideline on the management of Crohn\u2019s disease after surgical resection","volume":"152","author":"Nguyen","year":"2017","journal-title":"Gastroenterology."},{"key":"2022010520142550800_CIT0012","doi-asserted-by":"crossref","first-page":"S-227","DOI":"10.1016\/S0016-5085(14)60802-7","article-title":"Sa1198 agreement among experts in the endoscopic evaluation of postoperative recurrence in Crohn\u2019s disease using the Rutgeerts score","volume":"146","author":"Gecse","year":"2014","journal-title":"Gastroenterology"},{"key":"2022010520142550800_CIT0013","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/CEG.S96078","article-title":"Optimal delivery of follow-up care after surgery for Crohn\u2019s disease: current perspectives","volume":"9","author":"Campbell","year":"2016","journal-title":"Clin Exp Gastroenterol."},{"key":"2022010520142550800_CIT0014","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1572-0241.2000.02000.x","article-title":"Medical therapy to reduce postoperative Crohn\u2019s disease recurrence","volume":"95","author":"Achkar","year":"2000","journal-title":"Am J Gastroenterol."},{"key":"2022010520142550800_CIT0015","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/gut.2010.221705","article-title":"Pathogenesis of postoperative recurrence in Crohn\u2019s disease","volume":"60","author":"Ahmed","year":"2011","journal-title":"Gut."},{"key":"2022010520142550800_CIT0016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2009.579","article-title":"The natural history of adult Crohn\u2019s disease in population-based cohorts","volume":"105","author":"Peyrin-Biroulet","year":"2010","journal-title":"Am J Gastroenterol."},{"key":"2022010520142550800_CIT0017","doi-asserted-by":"crossref","first-page":"e2011028","DOI":"10.4084\/mjhid.2011.028","article-title":"The role of infection in the pathogenesis of vaso-occlusive crisis in patients with sickle cell disease","volume":"3","author":"Ahmed","year":"2011","journal-title":"Mediterr J Hematol Infect Dis."},{"key":"2022010520142550800_CIT0018","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/DCR.0b013e31828cb80c","article-title":"Repeat intestinal resections increase the risk of recurrence of Crohn\u2019s disease","volume":"56","author":"Riss","year":"2013","journal-title":"Dis Colon Rectum."},{"key":"2022010520142550800_CIT0019","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10350-008-9348-7","article-title":"Risk factors for surgical recurrence after ileocolic resection of Crohn\u2019s disease","volume":"51","author":"Unkart","year":"2008","journal-title":"Dis Colon Rectum."},{"key":"2022010520142550800_CIT0020","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1097\/MIB.0000000000000123","article-title":"Risk factors for repetitive ileocolic resection in patients with Crohn\u2019s disease: results of an observational cohort study","volume":"20","author":"Manser","year":"2014","journal-title":"Inflamm Bowel Dis."},{"key":"2022010520142550800_CIT0021","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1572-0241.2007.01548.x","article-title":"A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn\u2019s disease","volume":"103","author":"Simillis","year":"2008","journal-title":"Am J Gastroenterol."},{"key":"2022010520142550800_CIT0022","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00000658-200001000-00006","article-title":"Risk factors for surgery and postoperative recurrence in Crohn\u2019s disease","volume":"231","author":"Bernell","year":"2000","journal-title":"Ann Surg."},{"key":"2022010520142550800_CIT0023","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/ecco-jcc\/jju028","article-title":"Risk factors for postoperative intra-abdominal septic complications after surgery in Crohn\u2019s disease: a meta-analysis of observational studies","volume":"9","author":"Huang","year":"2015","journal-title":"J Crohns Colitis."},{"key":"2022010520142550800_CIT0024","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00000658-198403000-00015","article-title":"Postoperative recurrence in Crohn\u2019s disease. The effect of the initial length of bowel resection and operative procedure","volume":"199","author":"Ellis","year":"1984","journal-title":"Ann Surg."},{"key":"2022010520142550800_CIT0025","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s002689900398","article-title":"Factors determining recurrence following surgery for Crohn\u2019s disease","volume":"22","author":"Wolff","year":"1998","journal-title":"World J Surg."},{"key":"2022010520142550800_CIT0026","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1007\/s10350-007-9011-8","article-title":"A meta-analysis comparing conventional end-to-end anastomosis vs. other anastomotic configurations after resection in Crohn\u2019s disease","volume":"50","author":"Simillis","year":"2007","journal-title":"Dis Colon Rectum."},{"key":"2022010520142550800_CIT0027","first-page":"651","article-title":"Risk stratification for prevention of recurrence of postoperative Crohn\u2019s disease","volume":"13","author":"Cohen-Mekelburg","year":"2017","journal-title":"Gastroenterol Hepatol (N Y)."},{"key":"2022010520142550800_CIT0028","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/j.gastro.2016.10.039","article-title":"American Gastroenterological Association Institute Technical Review on the management of Crohn\u2019s disease after surgical resection","volume":"152","author":"Regueiro","year":"2017","journal-title":"Gastroenterology."},{"key":"2022010520142550800_CIT0029","first-page":"335","article-title":"Natural history of ileo-caecal Crohn\u2019s disease after surgical resection. A long term study","volume":"57","author":"Margagnoni","year":"2011","journal-title":"Minerva Gastroenterol Dietol."},{"key":"2022010520142550800_CIT0030","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/gut.25.6.665","article-title":"Natural history of recurrent Crohn\u2019s disease at the ileocolonic anastomosis after curative surgery","volume":"25","author":"Rutgeerts","year":"1984","journal-title":"Gut."},{"key":"2022010520142550800_CIT0031","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1053\/j.gastro.2008.07.066","article-title":"Meta-analysis of the placebo rates of clinical relapse and severe endoscopic recurrence in postoperative Crohn\u2019s disease","volume":"135","author":"Renna","year":"2008","journal-title":"Gastroenterology."},{"key":"2022010520142550800_CIT0032","first-page":"30","article-title":"Multiple imputation with multivariate imputation by chained equation (MICE) package","volume":"4","author":"Zhang","year":"2016","journal-title":"Ann Transl Med."},{"key":"2022010520142550800_CIT0033","article-title":"Rates of post-operative recurrence of Crohn\u2019s disease and effects of immunosuppressive and biologic therapies","author":"Riviere","year":"2020","journal-title":"Clin Gastroenterol Hepatol."},{"key":"2022010520142550800_CIT0034","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00384-008-0542-9","article-title":"The effect of smoking after surgery for Crohn\u2019s disease: a meta-analysis of observational studies","volume":"23","author":"Reese","year":"2008","journal-title":"Int J Colorectal Dis."},{"key":"2022010520142550800_CIT0035","first-page":"1","article-title":"Crohn\u2019s disease in Stockholm County 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis","volume":"490","author":"Hellers","year":"1979","journal-title":"Acta Chir Scand Suppl."},{"key":"2022010520142550800_CIT0036","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.3748\/wjg.v11.i26.3971","article-title":"Factors affecting recurrence after surgery for Crohn\u2019s disease","volume":"11","author":"Yamamoto","year":"2005","journal-title":"World J Gastroenterol."},{"key":"2022010520142550800_CIT0037","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/ibd.20922","article-title":"Established genetic risk factors do not distinguish early and later onset Crohn\u2019s disease","volume":"15","author":"Essers","year":"2009","journal-title":"Inflamm Bowel Dis."},{"key":"2022010520142550800_CIT0038","doi-asserted-by":"crossref","DOI":"10.1093\/ibd\/izz290","article-title":"The predictive value of inflammation at ileocecal resection margins for postoperative Crohn\u2019s recurrence: a cohort study","author":"Wasmann","year":"2020;26:1691\u20131699","journal-title":"Inflamm Bowel Dis"},{"key":"2022010520142550800_CIT0039","first-page":"491","article-title":"P0635: postoperative prophylactic thiopurines or biologicals are protective for clinical and endoscopic recurrence at short term follow-up after primary ileocecal resection in Crohn\u2019s disease, but not associated with a long-term beneficial effect on the risk of re-resection","volume":"8","author":"Arkenbosch","year":"2020","journal-title":"UEG J."},{"key":"2022010520142550800_CIT0040","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1053\/j.gastro.2016.02.072","article-title":"Infliximab reduces endoscopic, but not clinical, recurrence of Crohn\u2019s disease after ileocolonic resection","volume":"150","author":"Regueiro","year":"2016","journal-title":"Gastroenterology."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/28\/1\/1\/41890182\/izab044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/28\/1\/1\/41890182\/izab044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T20:15:00Z","timestamp":1641413700000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/28\/1\/1\/6203395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,30]]},"published-print":{"date-parts":[[2022,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izab044","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,3,30]]}}}