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It is believed that the chronic inflammation in CD is a result of an imbalance between the epithelial barrier, the immune system, and the intestinal microbiota. The aim of the study was to identify circulating markers associated with CD and\/or disease location in CD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We tested 49 cytokines, chemokines, and growth factors in serum samples from 300 patients with CD and 300 controls. After quality control, analyte levels were tested for association with CD and disease location.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 13 analytes that were higher in CD patients relative to healthy controls and that remained significant after conservative Bonferroni correction (P\u2005&amp;lt;\u20050.0015). In particular, CXCL9, CXCL1, and interleukin IL-6 had the greatest effect and were highly significant (P\u2005&amp;lt;\u20055\u2005\u00d7\u200510\u20137). We also identified 9 analytes that were associated with disease location, with VEGF, IL-12p70, and IL-6 being elevated in patients with colorectal disease (P\u2005&amp;lt;\u20053\u2005\u00d7\u200510\u20134).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Multiple serum analytes are elevated in CD. These implicate the involvement of multiple cell types from the immune, epithelial, and endothelial systems, suggesting that circulating analytes reflect the inflammatory processes that are ongoing within the gut. Moreover, the identification of distinct profiles according to disease location supports the existence of a biological difference between ileal and colonic CD, consistent with previous genetic and clinical observations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izab123","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T13:07:28Z","timestamp":1623244048000},"page":"9-20","source":"Crossref","is-referenced-by-count":26,"title":["Serum Analyte Profiles Associated With Crohn\u2019s Disease and Disease Location"],"prefix":"10.1093","volume":"28","author":[{"given":"Gabrielle","family":"Boucher","sequence":"first","affiliation":[{"name":"Montreal Heart Institute , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Paradis","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Chabot-Roy","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Coderre","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E","family":"Hillhouse","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bitton","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University , Montreal, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Des Rosiers","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"D\u00e9partement de Nutrition, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K","family":"Levings","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital Research Institute , Vancouver, British Columbia , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Philip","family":"Schumm","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lazarev","sequence":"additional","affiliation":[{"name":"The Harvey M. and Lyn P. 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