{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:18:43Z","timestamp":1776665923224,"version":"3.51.2"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U19AR069522"],"award-info":[{"award-number":["U19AR069522"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DK007634"],"award-info":[{"award-number":["T32DK007634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Studies of adults with Crohn\u2019s disease (CD) suggest that poor mental health precedes worsening disease activity. We evaluated whether depression and\/or anxiety forecast worsening pediatric CD disease activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Through the Inflammatory Bowel Disease Partners Kids &amp; Teens internet-based cohort, children with CD age 9 to 17 completed Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures and the short Crohn\u2019s disease activity index (sCDAI). Using general linear models, we examined how baseline PROMIS Pediatric anxiety and depressive symptom scores independently associate with subsequent sCDAI scores (average survey interval 6.4 months). Models included baseline PROMIS Pediatric anxiety and depressive symptoms scores, baseline sCDAI, sex, age, parental education, race\/ethnicity, and prior IBD-related surgery. We performed a post hoc subanalysis of children in baseline remission (sCDAI &amp;lt;150) with otherwise identical models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We analyzed 159 children with CD (mean age 14 years, 45% female, 84% in baseline remission). We found no association between baseline PROMIS Pediatric anxiety score and subsequent sCDAI (change in sCDAI for 3-point change in PROMIS Pediatric \u22120.89; 95% CI \u22124.81 to 3.03). Baseline PROMIS Pediatric depressive symptoms score was not associated with future sCDAI (change in sCDAI for 3-point change in PROMIS Pediatric &amp;lt;0.01; 95% CI \u22124.54 to 4.53). In a subanalysis of patients in remission at baseline, the lack of association remained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We found that neither anxiety nor depressive symptoms associate with subsequent disease activity in pediatric CD. These findings contrast with adult IBD studies, thus underschoring the unique pathophysiology, natural history, and outcomes of pediatric CD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izab162","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T15:27:20Z","timestamp":1625930840000},"page":"728-733","source":"Crossref","is-referenced-by-count":4,"title":["Anxiety and Depressive Symptoms Are Not Associated With Future Pediatric Crohn\u2019s Disease Activity"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-3637","authenticated-orcid":false,"given":"Erica J","family":"Brenner","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Millie 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America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Reyes","sequence":"additional","affiliation":[{"name":"Office of Clinical Research, School of Medicine, Duke University , Durham, North Carolina , United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten M","family":"Bahnson","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, School of Medicine, Duke University , Durham, North Carolina , United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-8714","authenticated-orcid":false,"given":"Bryce B","family":"Reeve","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, School of Medicine, Duke University , Durham, North Carolina , United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D","family":"Kappelman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"2022092311480872100_CIT0001","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ibd\/izx100","article-title":"Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part I","volume":"24","author":"Knowles","year":"2018","journal-title":"Inflamm Bowel Dis."},{"key":"2022092311480872100_CIT0002","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/MOP.0b013e3282ef4426","article-title":"Psychological factors affecting pediatric inflammatory bowel disease","volume":"19","author":"Mackner","year":"2007","journal-title":"Curr Opin 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