{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:07:56Z","timestamp":1790838476723,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011684","name":"Crohn\u2019s & Colitis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with Crohn\u2019s disease (CD) undergo frequent endoscopic procedures, with visualization of the gastrointestinal mucosa central to treatment decision-making. Subsequently, a noninvasive alternative to optical colonoscopy (OC) would be welcomed. One such technology is capsule endoscopy, including the PillCam COLON 2 (PCC2), though research validating its use in ileocolonic CD is limited. This study aims to compare PCC2 with ileocolonoscopy (OC) in assessing mucosal CD through use of a standardized scoring system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>At an Australian tertiary hospital, same-day PCC2 and ileocolonoscopy results of 47 CD patients, with known nonstricturing disease, were prospectively collected and analyzed for correlation and agreement. Deidentified recordings were reported by a single expert gastroenterologist. Mucosal disease was quantified using the Simple Endoscopic Score for Crohn\u2019s Disease (SES-CD). The SES-CD results of paired endoscopic modalities were compared in total per bowel segment and per SES-CD variable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 47 PCC2 recordings, 68% were complete, fully assessing terminal ileum to rectum, and OC was complete in 89%. Correlation (r) between total SES-CD scores was strongest in the terminal ileum (r\u2005=\u20050.77, P\u2005&amp;lt; .001), with the SES-CD variable of \u201culcer detection\u201d showing the strongest agreement. The PCC2 (vs OC) identified additional ulcers in the terminal ileum; ascending, transverse, and descending colon; and rectum; scores were 5 (1), 5 (3), 1 (1), 2 (1), and 2 (2), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The PCC2 shows promise in assessing ileocolonic mucosa, especially in proximal bowel segments, with greater reach of visualization in the small bowel. Given the resource and safety considerations raised by the Coronavirus disease 2019 pandemic, capsule endoscopy has particular significance.<\/jats:p>\n                  <jats:p>This article aims to contribute to the limited body of research surrounding the validity of capsule endoscopy technology in assessing ileocolonic mucosa in Crohn\u2019s Disease patients. In doing so, an alternative option for patients enduring frequent endoscopies is given potential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izab180","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T03:52:30Z","timestamp":1637207550000},"page":"S25-S32","source":"Crossref","is-referenced-by-count":14,"title":["Colon Capsule Endoscopy in the Assessment of Mucosal Healing in Crohn\u2019s Disease"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-4549","authenticated-orcid":false,"given":"Isabella","family":"Papalia","sequence":"first","affiliation":[{"name":"The University of Melbourne , Parkville, VIC , Australia"},{"name":"Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital , Parkville, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Tjandra","sequence":"additional","affiliation":[{"name":"Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital , Parkville, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Quah","sequence":"additional","affiliation":[{"name":"Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital , Parkville, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital , Parkville, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gorelik","sequence":"additional","affiliation":[{"name":"Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital , Parkville, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Sivanesan","sequence":"additional","affiliation":[{"name":"Department of Colorectal Medicine and 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