{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:40:02Z","timestamp":1767969602929,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The role of genetic and environmental factors in inflammatory bowel disease\u2019s (IBD) clinical course is not fully clear. We aimed to assess the clinical phenotype, disease course, and prognosis of familial IBD in comparison with sporadic cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective national matched case-control study of registered IBD patients in the Iranian Registry of Crohn\u2019s and Colitis (IRCC) recruited from 2017 until 2020. Sporadic and familial IBD patients were matched based on age, sex, and disease duration. Data on demographics, past medical disease, family history of IBD, disease type, clinical phenotype, extraintestinal manifestations, IBD medications, IBD activity using the IBD-control-8 questionnaire and the Manitoba IBD index, emergency visits in the past 12 months, admissions in the past 3 months, history of colon cancer, IBD-related surgeries, and aggressive phenotype were gathered. Variable distributions were compared between sporadic and familial cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 5231 patients with ulcerative colitis (UC, 18.3% familial) and 1438 patients with Crohn\u2019s disease (CD, 16.7% familial) were registered in the IRCC. Age at diagnosis was similar between familial and sporadic cases. After matching, 3523 UC patients and 908 CD patients were enrolled in the study. Extraintestinal manifestations, UC extent, CD location and behavior, anti-TNF use, disease activity, colon cancer, IBD-related surgeries and the aggressive phenotype were similar between these sporadic and familial cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence of familial UC and CD cases in Iran was more similar to western countries, and family history did not show a predictive value for disease phenotype, course, and outcomes in our study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izab202","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T13:40:47Z","timestamp":1629553247000},"page":"1004-1011","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Phenotype and Disease Course of Inflammatory Bowel Disease: A Comparison Between Sporadic and Familial Cases"],"prefix":"10.1093","volume":"28","author":[{"given":"Bahar","family":"Saberzadeh-Ardestani","sequence":"first","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Anushiravani","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariborz","family":"Mansour-Ghanaei","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences , Rasht , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafez","family":"Fakheri","sequence":"additional","affiliation":[{"name":"Gut and Liver Research Center, Mazandaran University of Medical Sciences , Sari , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homayoon","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farshad","family":"Sheikhesmaeili","sequence":"additional","affiliation":[{"name":"Liver and Digestive Research Center, Kurdistan University of Medical Sciences , Sanandaj , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Yazdanbod","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, Digestive Diseases Research Center, Ardabil University of Medical Sciences , Ardabil , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hamid","family":"Moosavy","sequence":"additional","affiliation":[{"name":"Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences , Bandar Abbas , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Vosoghinia","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hematology Department, Faculty of Medicine, Ghaem Hospital , Mashhad , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iradj","family":"Maleki","sequence":"additional","affiliation":[{"name":"Gut and Liver Research Center, Mazandaran University of Medical Sciences , Sari , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siavosh","family":"Nasseri-Moghaddam","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bardia","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoud","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Kasaeian","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"},{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudabeh","family":"Alatab","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-4631","authenticated-orcid":false,"given":"Anahita","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Kolahdoozan","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Rayatpisheh","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1397-4846","authenticated-orcid":false,"given":"Ali Reza","family":"Sima","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences , Tehran , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"key":"2022070108565393900_CIT0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Collaborators GBDIBD.","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2022070108565393900_CIT0002","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/ecco-jcc\/jjz081","article-title":"A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015","volume":"13","author":"Park","year":"2019","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0003","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.crohns.2013.01.010","article-title":"The burden of inflammatory bowel disease in Europe","volume":"7","author":"Burisch","year":"2013","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0004","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2015.11.029","article-title":"The changing landscape of inflammatory bowel disease: east meets west","volume":"150","author":"Kaplan","year":"2016","journal-title":"Gastroenterology."},{"key":"2022070108565393900_CIT0005","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet."},{"key":"2022070108565393900_CIT0006","first-page":"619","article-title":"Prevalence of inflammatory bowel disease in pediatric and adult populations: recent estimates from large national databases in the United States, 2007-2016","volume":"26","author":"Ye","year":"2020","journal-title":"Inflamm Bowel Dis."},{"key":"2022070108565393900_CIT0007","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/ajg.2015.50","article-title":"Familial risk of inflammatory bowel disease: a population-based cohort study 1977\u20132011","volume":"110","author":"Moller","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2022070108565393900_CIT0008","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1572-0241.2006.00381.x","article-title":"A population-based case control study of potential risk factors for IBD","volume":"101","author":"Bernstein","year":"2006","journal-title":"Am J Gastroenterol."},{"key":"2022070108565393900_CIT0009","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1097\/01.mib.0000235094.01608.59","article-title":"Familial occurrence of inflammatory bowel disease in Korea","volume":"12","author":"Park","year":"2006","journal-title":"Inflamm Bowel Dis."},{"key":"2022070108565393900_CIT0010","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/gast.1996.v111.pm8780562","article-title":"Familial aggregation in Crohn\u2019s disease: increased age-adjusted risk and concordance in clinical characteristics","volume":"111","author":"Peeters","year":"1996","journal-title":"Gastroenterology."},{"key":"2022070108565393900_CIT0011","doi-asserted-by":"crossref","first-page":"556","DOI":"10.4292\/wjgpt.v7.i4.556","article-title":"Family history and disease outcomes in patients with Crohn\u2019s disease: a comparison between China and the United States","volume":"7","author":"Wang","year":"2016","journal-title":"World J Gastrointest Pharmacol Ther."},{"key":"2022070108565393900_CIT0012","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","article-title":"Environmental triggers in IBD: a review of progress and evidence","volume":"15","author":"Ananthakrishnan","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"2022070108565393900_CIT0013","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1572-0241.2007.01124.x","article-title":"Inflammatory bowel disease in the South Asian pediatric population of British Columbia","volume":"102","author":"Pinsk","year":"2007","journal-title":"Am J Gastroenterol."},{"key":"2022070108565393900_CIT0014","doi-asserted-by":"crossref","first-page":"e00213","DOI":"10.14309\/ctg.0000000000000213","article-title":"Host genetic and gut microbial signatures in familial inflammatory bowel disease","volume":"11","author":"Park","year":"2020","journal-title":"Clin Transl Gastroenterol."},{"key":"2022070108565393900_CIT0015","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00535-012-0558-3","article-title":"Effects of family history on inflammatory bowel disease characteristics in Japanese patients","volume":"47","author":"Kuwahara","year":"2012","journal-title":"J Gastroenterol."},{"key":"2022070108565393900_CIT0016","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5217\/ir.2018.00174","article-title":"Familial aggregation of inflammatory bowel disease in India: prevalence, risks and impact on disease behavior","volume":"17","author":"Banerjee","year":"2019","journal-title":"Intest Res."},{"key":"2022070108565393900_CIT0017","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/ecco-jcc\/jjx154","article-title":"Differences in Clinical course, genetics, and the microbiome between familial and sporadic inflammatory bowel diseases","volume":"12","author":"Borren","year":"2018","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0018","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00054725-200405000-00004","article-title":"Clinical characteristics of familial versus sporadic Crohn\u2019s disease using the Vienna classification","volume":"10","author":"Dorn","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"2022070108565393900_CIT0019","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/(SICI)1096-8628(20000529)92:3<178::AID-AJMG4>3.0.CO;2-P","article-title":"Anticipation in inflammatory bowel disease: a phenomenon caused by an accumulation of confounders","volume":"92","author":"Hampe","year":"2000","journal-title":"Am J Med Genet"},{"key":"2022070108565393900_CIT0020","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/00365520212511","article-title":"Familial and sporadic inflammatory bowel disease: comparison of clinical features and serological markers in a genetically homogeneous population","volume":"37","author":"Halme","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"2022070108565393900_CIT0021","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5217\/ir.2018.00157","article-title":"Iranian registry of Crohn\u2019s and Colitis: study profile of first nation-wide inflammatory bowel disease registry in Middle East","volume":"17","author":"Malekzadeh","year":"2019","journal-title":"Intest Res."},{"key":"2022070108565393900_CIT0022","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/MCG.0000000000000660","article-title":"World gastroenterology organisation global guidelines inflammatory bowel disease: update August 2015","volume":"50","author":"Bernstein","year":"2016","journal-title":"J Clin Gastroenterol."},{"key":"2022070108565393900_CIT0023","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications","volume":"55","author":"Satsangi","year":"2006","journal-title":"Gut."},{"key":"2022070108565393900_CIT0024","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/gutjnl-2013-305600","article-title":"Development and validation of a rapid, generic measure of disease control from the patient\u2019s perspective: the IBD-control questionnaire","volume":"63","author":"Bodger","year":"2014","journal-title":"Gut."},{"key":"2022070108565393900_CIT0025","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/ajg.2009.197","article-title":"The Manitoba IBD index: evidence for a new and simple indicator of IBD activity","volume":"104","author":"Clara","year":"2009","journal-title":"Am J Gastroenterol."},{"key":"2022070108565393900_CIT0026","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/ecco-jcc\/jjx161","article-title":"Developing a standard set of patient-centred outcomes for inflammatory bowel disease-an international, cross-disciplinary consensus","volume":"12","author":"Kim","year":"2018","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0027","doi-asserted-by":"crossref","first-page":"17120","DOI":"10.3748\/wjg.v20.i45.17120","article-title":"Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea","volume":"20","author":"Chung","year":"2014","journal-title":"World J Gastroenterol."},{"key":"2022070108565393900_CIT0028","first-page":"710","article-title":"Inflammatory bowel disease in children: the role of a positive family history","volume":"22","author":"Roma","year":"2010","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"2022070108565393900_CIT0029","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.crohns.2014.05.008","article-title":"Family history of inflammatory bowel disease among patients with ulcerative colitis: a systematic review and meta-analysis","volume":"8","author":"Childers","year":"2014","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jgh.14872","article-title":"The epidemiology of inflammatory bowel disease: East meets west","volume":"35","author":"Mak","year":"2020","journal-title":"J Gastroenterol Hepatol."},{"key":"2022070108565393900_CIT0031","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/ecco-jcc\/jjy016","article-title":"Does Familial IBD Have its Own Signature?","volume":"12","author":"Chao","year":"2018","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0032","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1111\/j.1572-0241.2007.01368.x","article-title":"Are there any differences in phenotype or disease course between familial and sporadic cases of inflammatory bowel disease? Results of a population-based follow-up study","volume":"102","author":"Henriksen","year":"2007","journal-title":"Am J Gastroenterol."},{"key":"2022070108565393900_CIT0033","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ecco-jcc\/jjw063","article-title":"Influence of a positive family history on the clinical course of inflammatory bowel disease","volume":"10","author":"Hwang","year":"2016","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0034","first-page":"285","article-title":"Familial ulcerative colitis in Israeli Jews: its prevalence and clinical severity compared to sporadic disease","volume":"24","author":"Ben-Horin","year":"2011","journal-title":"Ann Gastroenterol."},{"key":"2022070108565393900_CIT0035","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.crohns.2013.12.005","article-title":"Phenotypic concordance in familial inflammatory bowel disease (IBD). Results of a nationwide IBD Spanish database","volume":"8","author":"Cabr\u00e9","year":"2014","journal-title":"J Crohns Colitis."},{"key":"2022070108565393900_CIT0036","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1053\/gast.1996.v111.pm8780561","article-title":"Inflammatory bowel disease in 67 families each with three or more affected first-degree relatives","volume":"111","author":"Lee","year":"1996","journal-title":"Gastroenterology."},{"key":"2022070108565393900_CIT0037","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ajg.2010.343","article-title":"Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort","volume":"106","author":"Vavricka","year":"2011","journal-title":"Am J Gastroenterol."},{"key":"2022070108565393900_CIT0038","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1053\/gast.1996.v111.pm8780563","article-title":"Clinical characteristics of Crohn\u2019s disease in 72 families","volume":"111","author":"Colombel","year":"1996","journal-title":"Gastroenterology."},{"key":"2022070108565393900_CIT0039","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/MEG.0000000000000877","article-title":"Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease","volume":"29","author":"Dragasevic","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2022070108565393900_CIT0040","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1053\/gast.1996.v111.pm8780560","article-title":"Crohn\u2019s disease: influence of age at diagnosis on site and clinical type of disease","volume":"111","author":"Polito","year":"1996","journal-title":"Gastroenterology"},{"key":"2022070108565393900_CIT0041","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11845-020-02326-z","article-title":"The development of extraintestinal manifestation and related risk factors in Crohn\u2019s patients","volume":"190","author":"Kayar","year":"2020","journal-title":"Ir J Med Sci"},{"key":"2022070108565393900_CIT0042","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ibd.20740","article-title":"Familial clustering of Crohn\u2019s disease in Israel: prevalence and association with disease severity","volume":"15","author":"Ben-Horin","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"2022070108565393900_CIT0043","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0140-6736(15)00465-1","article-title":"Inherited determinants of Crohn\u2019s disease and ulcerative colitis phenotypes: a genetic association study","volume":"387","author":"Cleynen","year":"2016","journal-title":"Lancet."},{"key":"2022070108565393900_CIT0044","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/gut.52.4.558","article-title":"CARD15\/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn\u2019s disease","volume":"52","author":"Heli\u00f6","year":"2003","journal-title":"Gut."},{"key":"2022070108565393900_CIT0045","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00384-011-1145-4","article-title":"NOD2 exonic variations in Iranian Crohn\u2019s disease patients","volume":"26","author":"Naderi","year":"2011","journal-title":"Int J Colorectal Dis."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/28\/7\/1004\/44267839\/izab202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/28\/7\/1004\/44267839\/izab202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T08:58:40Z","timestamp":1656665920000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/28\/7\/1004\/6356100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,21]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,8,21]]},"published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izab202","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2021,8,21]]}}}