{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:00:04Z","timestamp":1774728004417,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development, LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005565","name":"Janssen Biotech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"Abbvie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endoscopic mucosal healing is the gold standard for evaluating Crohn\u2019s disease (CD) treatment efficacy. Standard endoscopic indices are not routinely used in clinical practice, limiting the quality of retrospective research. A method for retrospectively quantifying mucosal activity from documentation is needed. We evaluated the simplified endoscopic mucosal assessment for CD (SEMA-CD) to determine if it can accurately quantify mucosal severity recorded in colonoscopy reports.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Pediatric patients with CD underwent colonoscopy that was video recorded and evaluated via Simple Endoscopic Score for CD (SES-CD) and SEMA-CD by central readers. Corresponding colonoscopy reports were de-identified. Central readers blinded to clinical history and video scoring were randomly assigned colonoscopy reports with and without images. The SEMA-CD was scored for each report. Correlation with video SES-CD and SEMA-CD were assessed with Spearman rho, inter-rater, and intrarater reliability with kappa statistics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-seven colonoscopy reports were read a total of 347 times. The simplified endoscopic mucosal assessment for CD without images correlated with both SES-CD and SEMA-CD from videos (rho\u2005=\u20050.82, P\u2005&amp;lt; .0001 for each). The addition of images provided similar correlation. Inter-rater and intrarater reliability were 0.93 and 0.92, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The SEMA-CD applied to retrospective evaluation of colonoscopy reports accurately and reproducibly correlates with SES-CD and SEMA-CD of colonoscopy videos. The SEMA-CD for evaluating colonoscopy reports will enable quantifying mucosal healing in retrospective research. Having objective outcome data will enable higher-quality research to be conducted across multicenter collaboratives and in clinical registries. External validation is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izab315","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T13:52:40Z","timestamp":1640785960000},"page":"1537-1542","source":"Crossref","is-referenced-by-count":7,"title":["Quantification of Mucosal Activity from Colonoscopy Reports via the Simplified Endoscopic Mucosal Assessment for Crohn\u2019s Disease"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-6098","authenticated-orcid":false,"given":"Jeremy","family":"Adler","sequence":"first","affiliation":[{"name":"C.S. Mott Children\u2019s Hospital, Michigan Medicine, University of Michigan , Ann Arbor, MI , USA"},{"name":"Susan B. Meister Child Health Evaluation and Research Center, Michigan Medicine, University of Michigan , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally J","family":"Eder","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, Michigan Medicine, University of Michigan , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Acham","family":"Gebremariam","sequence":"additional","affiliation":[{"name":"Susan B. Meister Child Health Evaluation and Research Center, Michigan Medicine, University of Michigan , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J","family":"Moran","sequence":"additional","affiliation":[{"name":"MassGeneral Hospital for Children, Harvard Medical School , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee M","family":"Bass","sequence":"additional","affiliation":[{"name":"Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Moses","sequence":"additional","affiliation":[{"name":"UH\/Rainbow Babies & Children\u2019s Hospital, Division of Pediatric Gastroenterology, Hepatology and Nutrition , Cleveland, OH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery D","family":"Lewis","sequence":"additional","affiliation":[{"name":"GI Care for Kids , Atlanta, GA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A M","family":"Singer","sequence":"additional","affiliation":[{"name":"C.S. Mott Children\u2019s Hospital, Michigan Medicine, University of Michigan , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina L","family":"Morhardt","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital at Dartmouth-Hitchcock , Lebanon, NH , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A","family":"Picoraro","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Alabama, University of Alabama Birmingham , Birmingham, AL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M","family":"Zacur","sequence":"additional","affiliation":[{"name":"C.S. Mott Children\u2019s Hospital, Michigan Medicine, University of Michigan , Ann Arbor, MI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B","family":"Colletti","sequence":"additional","affiliation":[{"name":"University of Vermont Children\u2019s Hospital , Burlington, VT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"2023112212510845300_CIT0001","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in 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