{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:04:48Z","timestamp":1781661888983,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>It has been suggested that eosinophils may be a prognostic marker of disease outcome in ulcerative colitis (UC), but conflicting data exist. The objective was to investigate the extent of mucosal eosinophils and peripheral blood eosinophil count in newly diagnosed UC patients and to investigate its predictive value in short- and long-term disease outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The degree of eosinophilia in baseline colonic biopsies and blood of newly diagnosed UC patients was retrospectively analyzed. It was investigated if tissue and blood eosinophilia could be a marker of a severe phenotype of UC, defined as the need for corticosteroids or immunomodulators in the first year or treatment with therapeutic monoclonal antibodies or colectomy during follow-up. Time to therapeutic monoclonal antibodies and time to colectomy were also evaluated as outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 103 UC patients (median age 26 years) included. Median tissue peak eosinophil count (PEC) was 70.0 and median peripheral blood eosinophil count was 0.3\u2005\u00d7\u2005109\/L at diagnosis. Tissue PEC (r\u2005=\u2005-0.161, P = .104) and blood eosinophil count (r\u2005=\u20050.022, P = .877) were not correlated with the severity of histologic inflammation. Logistic regression analyses did not identify PEC and blood eosinophil count as predictors of more severe disease outcomes. Tissue PEC and peripheral blood eosinophil count did not predict the time the initiation of therapeutic monoclonal antibodies or colectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Baseline tissue or peripheral blood eosinophils are not markers of disease activity and cannot be used as a predictor of severe disease outcomes in both adults and children with UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izac044","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T14:35:03Z","timestamp":1647009303000},"page":"62-69","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic Value of Colonic Tissue and Blood Eosinophils in Ulcerative Colitis"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-067X","authenticated-orcid":false,"given":"Maria L","family":"Haasnoot","sequence":"first","affiliation":[{"name":"Department of Gastroenterology & Hepatology , Amsterdam UMC, Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aart","family":"Mookhoek","sequence":"additional","affiliation":[{"name":"Department of Pathology , Amsterdam UMC, Amsterdam , the Netherlands"},{"name":"Institute of Pathology, University of Bern , Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn","family":"Duijvestein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology , Amsterdam UMC, Amsterdam , the Netherlands"},{"name":"Department of Gastroenterology and Hepatology , Radboudumc, Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R A M","family":"D\u2019Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology , Amsterdam UMC, Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology , Amsterdam UMC, Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"issue":"3","key":"2023010801582290700_CIT0001","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG clinical guideline: ulcerative colitis in adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am J Gastroenterol."},{"issue":"10","key":"2023010801582290700_CIT0002","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.crohns.2013.06.001","article-title":"European consensus on the histopathology of inflammatory bowel disease","volume":"7","author":"Magro","year":"2013","journal-title":"J Crohns Colitis."},{"issue":"3","key":"2023010801582290700_CIT0003","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bpg.2007.12.001","article-title":"Role of gastrointestinal eosinophils in inflammatory bowel disease and intestinal tumours","volume":"22","author":"Wedemeyer","year":"2008","journal-title":"Best Pract Res Clin Gastroenterol."},{"issue":"3","key":"2023010801582290700_CIT0004","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4049\/jimmunol.1400413","article-title":"Roles and regulation of gastrointestinal eosinophils in immunity and disease","volume":"193","author":"Jung","year":"2014","journal-title":"J Immunol."},{"issue":"6","key":"2023010801582290700_CIT0005","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.jaip.2020.01.060","article-title":"Epidemiology of nonesophageal eosinophilic gastrointestinal diseases in symptomatic patients: a systematic review and meta-analysis","volume":"8","author":"Licari","year":"2020","journal-title":"J Allergy Clin Immunol Pract."},{"issue":"7","key":"2023010801582290700_CIT0006","doi-asserted-by":"crossref","first-page":"e14072","DOI":"10.1111\/nmo.14072","article-title":"Emerging incidence trends of eosinophilic esophagitis over 25 years: Results of a nationwide register-based pathology cohort","volume":"33","author":"de Rooij","year":"2021","journal-title":"Neurogastroenterol Motil."},{"issue":"6","key":"2023010801582290700_CIT0007","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/MPG.0b013e3182128512","article-title":"Role of eosinophils in inflammatory bowel and gastrointestinal diseases","volume":"52","author":"Woodruff","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"2023010801582290700_CIT0008","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.4049\/jimmunol.181.10.7390","article-title":"Intestinal macrophage\/epithelial cell-derived CCL11\/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis","volume":"181","author":"Ahrens","year":"2008","journal-title":"J Immunol."},{"issue":"12","key":"2023010801582290700_CIT0009","doi-asserted-by":"crossref","first-page":"O420","DOI":"10.1111\/codi.12725","article-title":"Severe eosinophilic infiltration in colonic biopsies predicts patients with ulcerative colitis not responding to medical therapy","volume":"16","author":"Zezos","year":"2014","journal-title":"Colorectal Dis."},{"key":"2023010801582290700_CIT0010","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF01296289","article-title":"Significance of eosinophil and mast cell counts in rectal mucosa in ulcerative colitis. a prospective controlled study","volume":"32","author":"Sarin","year":"1987","journal-title":"Dig Dis Sci."},{"issue":"2","key":"2023010801582290700_CIT0011","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.dld.2016.11.007","article-title":"Tissue and peripheral eosinophilia as predictors for disease outcome in children with ulcerative colitis","volume":"49","author":"Morgenstern","year":"2017","journal-title":"Dig Liver Dis."},{"issue":"12","key":"2023010801582290700_CIT0012","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10151-018-1896-9","article-title":"Colonic hypereosinophilia in ulcerative colitis may help to predict the failure of steroid therapy","volume":"22","author":"Leoncini","year":"2018","journal-title":"Tech Coloproctol."},{"issue":"8","key":"2023010801582290700_CIT0013","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ibd\/izz251","article-title":"Mucosal eosinophilia is an independent predictor of vedolizumab efficacy in inflammatory bowel diseases","volume":"26","author":"Kim","year":"2020","journal-title":"Inflamm Bowel Dis."},{"issue":"3","key":"2023010801582290700_CIT0014","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/1319-3767.80383","article-title":"Biological and histological parameters as predictors of relapse in ulcerative colitis: a prospective study","volume":"17","author":"Azad","year":"2011","journal-title":"Saudi J Gastroenterol."},{"issue":"2","key":"2023010801582290700_CIT0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/003655202753416885","article-title":"Biopsy pathology predicts patients with ulcerative colitis subsequently requiring surgery","volume":"37","author":"Tanaka","year":"2002","journal-title":"Scand J Gastroenterol."},{"key":"2023010801582290700_CIT0016","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/gut.20.9.787","article-title":"Eosinophils in the rectal mucosa. A simple method of predicting the outcome of ulcerative proctocolitis?","volume":"20","author":"Heatley","year":"1978","journal-title":"Gut."},{"issue":"12","key":"2023010801582290700_CIT0017","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S2468-1253(17)30252-2","article-title":"Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study","volume":"2","author":"Hyams","year":"2017","journal-title":"Lancet Gastroenterol Hepatol."},{"issue":"12","key":"2023010801582290700_CIT0018","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1038\/ajg.2017.402","article-title":"Peripheral eosinophilia in patients with inflammatory bowel disease defines an aggressive disease phenotype","volume":"112","author":"Click","year":"2017","journal-title":"Am J Gastroenterol."},{"issue":"12","key":"2023010801582290700_CIT0019","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/ibd\/izz323","article-title":"Peripheral blood eosinophilia and long-term severity in pediatric-onset inflammatory bowel disease","volume":"26","author":"Prathapan","year":"2020","journal-title":"Inflamm Bowel Dis."},{"issue":"1","key":"2023010801582290700_CIT0020","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10620-012-2329-7","article-title":"Recurrent blood eosinophilia in ulcerative colitis is associated with severe disease and primary sclerosing cholangitis","volume":"58","author":"Barrie","year":"2013","journal-title":"Dig Dis Sci."},{"issue":"11","key":"2023010801582290700_CIT0021","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/ecco-jcc\/jjaa110","article-title":"ECCO position paper: harmonization of the approach to ulcerative colitis histopathology","volume":"14","author":"Magro","year":"2020","journal-title":"J Crohns Colitis."},{"key":"2023010801582290700_CIT0022","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.47.3.404","article-title":"reproducible grading scale for histological assessment of inflammation in ulcerative colitis","volume":"47","author":"Geboes","year":"2000","journal-title":"Gut."},{"issue":"2","key":"2023010801582290700_CIT0023","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/ecco-jcc\/jjz123","article-title":"Comparing the continuous geboes score with the robarts histopathology index: definitions of histological remission and response and their relation to faecal calprotectin levels","volume":"14","author":"Magro","year":"2020","journal-title":"J Crohns Colitis."},{"key":"2023010801582290700_CIT0024","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/00365521.1970.12096623","article-title":"Cell density in lamina propria of the colon","volume":"5","author":"Binder","year":"1970","journal-title":"Scand J Gastroenterol."},{"issue":"12","key":"2023010801582290700_CIT0025","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gut.2005.066423","article-title":"Eosinophil granulocytes are activated during the remission phase of ulcerative colitis","volume":"54","author":"Lampinen","year":"2005","journal-title":"Gut."},{"issue":"4","key":"2023010801582290700_CIT0026","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/MPG.0000000000000957","article-title":"Prevalence of peripheral eosinophilia at diagnosis in children with inflammatory bowel disease","volume":"62","author":"Sadi","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr."},{"issue":"2","key":"2023010801582290700_CIT0027","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2478\/v10039-012-0029-3","article-title":"Mast cells and eosinophils are involved in activation of ulcerative colitis","volume":"57","author":"Stasikowska-Kanicka","year":"2012","journal-title":"Adv Med Sci."},{"key":"2023010801582290700_CIT0028","first-page":"395","article-title":"Tissue eosinophils in ulcerative colitis","volume":"14","author":"Willoughby","year":"1979","journal-title":"Scand J Gastroenterol."},{"issue":"7110","key":"2023010801582290700_CIT0029","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0140-6736(59)91472-2","article-title":"Eosinophil leucocytes in ulcerative colitis","volume":"274","author":"Riisager","year":"1959","journal-title":"Lancet."},{"key":"2023010801582290700_CIT0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.1996.262309.x","article-title":"Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease","volume":"28(1)","author":"Bischoff","year":"1996","journal-title":"Histopathology."},{"issue":"3","key":"2023010801582290700_CIT0031","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/gut.2007.136481","article-title":"Severe paediatric ulcerative colitis: incidence, outcomes and optimal timing for second-line therapy","volume":"57","author":"Turner","year":"2008","journal-title":"Gut."},{"issue":"6","key":"2023010801582290700_CIT0032","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.humpath.2007.10.012","article-title":"Evaluation of site-specific and seasonal variation in colonic mucosal eosinophils","volume":"39","author":"Polydorides","year":"2008","journal-title":"Hum Pathol."},{"key":"2023010801582290700_CIT0033","first-page":"363","article-title":"Geographic variations in eosinophil concentrations in normal colonic mucosa","volume":"10","author":"Pascal","year":"1997","journal-title":"Mod Pathol."},{"issue":"9084","key":"2023010801582290700_CIT0034","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0140-6736(05)70471-2","article-title":"Mesalazine activation of eosinophil","volume":"350","author":"Morice","year":"1997","journal-title":"Lancet."},{"key":"2023010801582290700_CIT0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/014107680710000314","article-title":"Mesalazine-induced bronchiectasis and eosinophilia in a patient with ulcerative colitis. A case report","volume":"100","author":"Price","year":"2007","journal-title":"J R Soc Med."},{"key":"2023010801582290700_CIT0036","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/0091-6749(94)90333-6","article-title":"The effects of glucocorticoids on human eosinophils","volume":"94","author":"Schleimer","year":"1984","journal-title":"J Allergy Clin Immunol."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izac044\/42843090\/izac044.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/29\/1\/62\/48343043\/izac044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/29\/1\/62\/48343043\/izac044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T02:01:27Z","timestamp":1673143287000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/29\/1\/62\/6547139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3,11]]},"published-print":{"date-parts":[[2023,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izac044","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,3,11]]}}}