{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:22:18Z","timestamp":1787008938851,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Emma Foundation of Amsterdam"},{"DOI":"10.13039\/501100003761","name":"UMC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003761","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cornelia Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is currently no consensus on the definition of an abnormal intestinal ultrasound (IUS) for children with ulcerative colitis (UC). This cross-sectional study aimed to externally validate and compare 2 existing IUS indices in children with UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children undergoing colonoscopy for UC assessment underwent IUS the day before colonoscopy, assessed with the Mayo endoscopic subscore. The UC-IUS index and the Civitelli index were compared with the Mayo endoscopic score in the ascending, transverse, and descending colon. The area under the receiver-operating characteristic curve for detecting a Mayo endoscopic score \u22652 of both scores was compared and sensitivity and specificity were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 35 UC patients were included (median age 15 years, 39% female). The area under the receiver-operating characteristic curve was higher for the UC-IUS index in the ascending colon (0.82 [95% confidence interval (CI), 0.67-0.97] vs 0.76 [95% CI, 0.59-0.93]; P = .046) and transverse colon (0.88 [95% CI, 0.76-1.00] vs 0.77 [95% CI, 0.60-0.93]; P = .01). In the descending colon, there was no difference (0.84 [95% CI, 0.70-0.99] vs 0.84 [95% CI, 0.70-0.98]). The optimal cutoff for the UC-IUS was &amp;lt;1 point to rule out a Mayo endoscopic score \u22652 (sensitivity: 88%, 100%, and 90% in the ascending, transverse, and descending colon, respectively) and a Mayo endoscopic score \u22652 could be detected using a cutoff of &amp;gt;1 (specificity: 84%, 83%, and 87%, respectively). For the Civitelli index, in our cohort, the optimal cutoff was &amp;lt;1 to rule out a Mayo endoscopic score \u22652 (sensitivity 75%, 65%, and 80%, respectively) and a cutoff &amp;gt;1 to detect a Mayo endoscopic score \u22652 (specificity 89%, 89%, and 93%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort, the UC-IUS index performed better than the Civitelli index. The UC-IUS index had both a high sensitivity and specificity in this cohort, when using 1 point as cutoff for a Mayo endoscopic score \u22652.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izac197","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T15:25:00Z","timestamp":1663946700000},"page":"1217-1222","source":"Crossref","is-referenced-by-count":23,"title":["Intestinal Ultrasound to Assess Ulcerative Colitis Disease Activity in Children: External Validation and Comparison of 2 Intestinal Ultrasound Activity Indices"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3149-953X","authenticated-orcid":false,"given":"Elsa A","family":"van Wassenaer","sequence":"first","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-6515","authenticated-orcid":false,"given":"Rick R","family":"van Rijn","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina L M","family":"Zwetsloot","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris A E","family":"de Voogd","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"van Schuppen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Kindermann","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim G J","family":"de Meij","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC and Vrije Universiteit Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan E","family":"van Limbergen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K B","family":"Gecse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R","family":"D\u2019Haens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart G P","family":"Koot","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"issue":"4","key":"2023080117200482000_CIT0001","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000358131","article-title":"An overview of the natural history of inflammatory bowel diseases","volume":"32","author":"Dom\u00e8nech","year":"2014","journal-title":"Dig 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