{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:13:36Z","timestamp":1786371216550,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1K08DK110421-01"],"award-info":[{"award-number":["1K08DK110421-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5P30DK097948-07"],"award-info":[{"award-number":["5P30DK097948-07"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1F31DK130587-01A1"],"award-info":[{"award-number":["1F31DK130587-01A1"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1U01CA248226-01"],"award-info":[{"award-number":["1U01CA248226-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014042","name":"Peer Reviewed Cancer Research Program","doi-asserted-by":"publisher","award":["W81XWH-21-1-0345"],"award-info":[{"award-number":["W81XWH-21-1-0345"]}],"id":[{"id":"10.13039\/100014042","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Hospitals\u2019 Research and Education Institutes Pilot Award"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. Government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early identification of Crohn\u2019s disease (CD) patients at risk for complications could enable targeted surgical referral, but routine magnetic resonance enterography (MRE) has not been definitively correlated with need for surgery. Our objective was to identify computer-extracted image (radiomic) features from MRE associated with risk of surgery in CD and combine them with clinical and radiological assessments to predict time to intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective single-center pilot study of CD patients who had an MRE within 3 months prior to initiating medical therapy. Radiomic features were extracted from annotated terminal ileum regions on MRE and combined with clinical variables and radiological assessment (via Simplified Magnetic Resonance Index of Activity scoring for wall thickening, edema, fat stranding, ulcers) in a random forest classifier. The primary endpoint was high- and low-risk groups based on need for surgery within 1 year of MRE. The secondary endpoint was time to surgery after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight radiomic features capturing localized texture heterogeneity within the terminal ileum were significantly associated with risk of surgery within 1 year of treatment (P &amp;lt; .05); yielding a discovery cohort area under the receiver-operating characteristic curve of 0.67 (n = 50) and validation cohort area under the receiver-operating characteristic curve of 0.74 (n = 23). Kaplan-Meier analysis of radiomic features together with clinical variables and Simplified Magnetic Resonance Index of Activity scores yielded the best hazard ratio of 4.13 (P = (7.6 \u00d7 10-6) and concordance index of 0.71 in predicting time to surgery after MRE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Radiomic features on MRE may be associated with risk of surgery in CD, and in combination with clinicoradiological scoring can yield an accurate prognostic model for time to surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izac211","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T18:36:54Z","timestamp":1666031814000},"page":"349-358","source":"Crossref","is-referenced-by-count":35,"title":["Integrating Radiomics With Clinicoradiological Scoring Can Predict High-Risk Patients Who Need Surgery in Crohn\u2019s Disease: A Pilot Study"],"prefix":"10.1093","volume":"29","author":[{"given":"Prathyush","family":"Chirra","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamay","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University Hospitals Cleveland Medical Center , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaustav","family":"Bera","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University , Cleveland, OH , USA"},{"name":"Department of Radiology, University Hospitals Cleveland Medical Center , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Matthew","family":"Cohn","sequence":"additional","affiliation":[{"name":"Long Island Digestive Disease Consultants, Northwell Health Physician Partners , Setauket, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-8998","authenticated-orcid":false,"given":"Jacob A","family":"Kurowski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelin","family":"Amann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco-Jose","family":"Rivero","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University Hospitals Cleveland Medical Center , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-0399","authenticated-orcid":false,"given":"Anant","family":"Madabhushi","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Radiology and Imaging Sciences, Biomedical Informatics (BMI) and Pathology, Georgia Institute of Technology and Emory University , Atlanta, GA , USA"},{"name":"Research Health Scientist, Atlanta Veterans Administration Medical Center , Atlanta, GA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajmohan","family":"Paspulati","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospitals Cleveland Medical Center , Cleveland, OH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospitals Cleveland Medical Center , Cleveland, OH , 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