{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:18:09Z","timestamp":1784269089831,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with an ileal pouch-anal anastomosis (IPAA) can experience pouch inflammation postoperatively. The use of antitumor necrosis factor (anti-TNF) biologics may be associated with pouch inflammation, but limited data exist on the impact of multiple advanced therapies on development of subsequent pouch inflammation. The aim of this study was to assess for an association between preoperative use of multiple advanced therapies and risk of endoscopically detected inflammatory pouch diseases (EIPDs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective analysis of ulcerative colitis (UC) and indeterminate colitis (IBDU) patients who underwent an IPAA at a quaternary care center from January 2015 to December 2019. Patients were grouped based on number and type of preoperative drug exposures. The primary outcome was EIPD within 5 years of IPAA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred ninety-eight patients were included in this analysis. Most of these patients had UC (95.0%) and demonstrated pancolonic disease distribution (86.1%). The majority of patients were male (57.4%) and underwent surgery for medically refractory disease (79.2%). The overall median age at surgery was 38.6 years. Preoperatively, 68 patients were biologic\/small molecule-na\u00efve, 125 received anti-TNF agents only, and 105 received non-anti-TNF agents only or multiple classes. Ninety-one patients developed EIPD. There was no significant association between type (P = .38) or number (P = .58) of exposures and EIPD, but older individuals had a lower risk of EIPD (P = .001; hazard ratio, 0.972; 95% confidence interval, 0.956-0.989).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Development of EIPD was not associated with number or type of preoperative advanced therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izad054","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T07:13:06Z","timestamp":1681629186000},"page":"203-212","source":"Crossref","is-referenced-by-count":3,"title":["Preoperative Use of Multiple Advanced Therapies Is Not Associated With Endoscopic Inflammatory Pouch Diseases"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-7934","authenticated-orcid":false,"given":"Joseph Carter","family":"Powers","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine of Case Western Reserve University , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Rieder","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H","family":"Click","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruishen","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Lerner Research Institute , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Foundation , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hull","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-9042","authenticated-orcid":false,"given":"Stefan","family":"Holubar","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel D","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6770-9055","authenticated-orcid":false,"given":"Taha","family":"Qazi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"issue":"6","key":"2024102107370111700_CIT0001","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European evidence-based consensus on diagnosis and management of ulcerative colitis. part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders","volume":"11","author":"Magro","year":"2017","journal-title":"J Crohns Colitis"},{"key":"2024102107370111700_CIT0002","doi-asserted-by":"crossref","article-title":"Ileal pouch-anal anastomosis in ulcerative colitis: outcomes, functional results, and quality of life in patients with more than 10-year follow-up","author":"Carcamo","DOI":"10.1007\/s00384-020-03529-7"},{"issue":"2","key":"2024102107370111700_CIT0003","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/bjs.7711","article-title":"Quality of life and health status before and after ileal pouch\u2013anal anastomosis for ulcerative colitis","volume":"99","author":"Heikens","year":"2012","journal-title":"Br J Surg."},{"issue":"10","key":"2024102107370111700_CIT0004","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S2468-1253(21)00101-1","article-title":"Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium","volume":"6","author":"Shen","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"7","key":"2024102107370111700_CIT0005","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/ibd\/izz227","article-title":"Inflammatory pouch conditions are common after ileal pouch anal anastomosis in ulcerative colitis patients","volume":"26","author":"Kayal","year":"2020","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"2024102107370111700_CIT0006","first-page":"191","article-title":"Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients","volume":"257","author":"Vw","year":"2013","journal-title":"Ann Surg."},{"issue":"7","key":"2024102107370111700_CIT0007","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/MIB.0000000000001119","article-title":"Pouch-related symptoms and quality of life in patients with ileal pouch-anal anastomosis","volume":"23","author":"Barnes","year":"2017","journal-title":"Inflamm Bowel Dis."},{"issue":"11","key":"2024102107370111700_CIT0008","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1463-1318.2012.02993.x","article-title":"Risk factors for chronic pouchitis after ileal pouch-anal anastomosis: a prospective cohort 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Hepatol."},{"issue":"2","key":"2024102107370111700_CIT0011","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cgh.2021.02.010","article-title":"Endoscopic phenotype of the J pouch in patients with inflammatory bowel disease: a new classification for pouch outcomes","volume":"20","author":"Akiyama","year":"2022","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"1","key":"2024102107370111700_CIT0012","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cgh.2022.04.015","article-title":"increasing incidence of pouchitis between 1996 and 2018: a population-based danish cohort study","volume":"21","author":"Barnes","year":"2022","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"11-12","key":"2024102107370111700_CIT0013","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/apt.15505","article-title":"Endoscopic activity in asymptomatic patients with an ileal pouch is associated with an increased risk of 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