{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:12:42Z","timestamp":1792289562490,"version":"4.4.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Several patients with ulcerative colitis (UC) suffer from psychiatric disorders, such as major depressive disorder, anxiety, or bipolar disorder, and show specific personality traits. Despite this, there are few data about personality profiles\u2019 characterization in UC patients and about correlation of their psychopathological profile with their intestinal microbiota.<\/jats:p>\n                  <jats:p>The aim of our study is to analyze the psychopathological and personality profile of UC patients and correlate it with specific signatures of their gut microbiota.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a prospective interventional longitudinal cohort study. We enrolled consecutive patients affected by UC attending to the IBD Unit of Center for Digestive Disease of \u201cA. Gemelli\u201d IRCCS Hospital in Rome and a group of healthy subjects, matched for specific characteristics. Each patient was evaluated by a gastroenterologist and a psychiatrist. Moreover, all participants underwent psychological tests and a collection of stool samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We recruited 39 UC patients and 37 healthy subjects. Most patients showed high level of alexithymia, anxiety symptoms, depressive symptoms, as well as neuroticism and hypochondria, with obsessive-compulsive features at the behavioral level, which significantly impaired their quality of life and abilities at work. Gut microbiota analysis in UC patients demonstrated an increase in actinobacteria, Proteobacteria and Saccharibacteria (TM7), with a reduction in verrucomicrobia, euryarchaeota and tenericutes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study confirmed the presence of high levels of psycho-emotional distress in UC patients, alongside alterations of the intestinal microbiota, and highlighted some families and genera of bacteria (Enterobacteriaceae, Streptococcus, Veillonella, Klebsiella, and Clostridiaceae) as potential markers of an altered gut-brain axis in these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izad091","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:06:35Z","timestamp":1686207995000},"page":"1805-1818","source":"Crossref","is-referenced-by-count":28,"title":["Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center"],"prefix":"10.1093","volume":"29","author":[{"given":"Franco","family":"Scaldaferri","sequence":"first","affiliation":[{"name":"UOS Malattie Infiammatorie Croniche Intestinali , Centro di Malattie dell\u2019Apparato Digerente (CEMAD), Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome, 00168 , Italy"},{"name":"Dipartimento di Medicina e Chirurgia traslazionale , Universit\u00e0 Cattolica del Sacro Cuore, Rome, 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"D\u2019Onofrio","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Sezione di Psichiatria , Universit\u00e0 Cattolica del Sacro Cuore, Rome, 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Calia","sequence":"additional","affiliation":[{"name":"Servizio di Psicologia Clinica , Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome, 00168 , Italy"},{"name":"Divisione di Chirurgia Generale e del Trapianto di Fegato, Dipartimento di Scienze Mediche e Chirurgiche , Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-7641","authenticated-orcid":false,"given":"Federica","family":"Di Vincenzo","sequence":"additional","affiliation":[{"name":"UOS Malattie Infiammatorie Croniche Intestinali , Centro di Malattie dell\u2019Apparato Digerente (CEMAD), Fondazione Policlinico Universitario \u201cA. 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