{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:15:20Z","timestamp":1791238520468,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK083256-13"],"award-info":[{"award-number":["5T32DK083256-13"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["PR181960"],"award-info":[{"award-number":["PR181960"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity is associated with progression of inflammatory bowel disease (IBD). Visceral adiposity may be a more meaningful measure of obesity compared with traditional measures such as body mass index (BMI). This study compared visceral adiposity vs BMI as predictors of time to IBD flare among patients with Crohn\u2019s disease and ulcerative colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study. IBD patients were included if they had a colonoscopy and computed tomography (CT) scan within a 30-day window of an IBD flare. They were followed for 6 months or until their next flare. The primary exposure was the ratio of visceral adipose tissue to subcutaneous adipose tissue (VAT:SAT) obtained from CT imaging. BMI was calculated at the time of index CT scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 100 Crohn\u2019s disease and 100 ulcerative colitis patients were included. The median age was 43 (interquartile range, 31-58) years, 39% had disease duration of 10 years or more, and 14% had severe disease activity on endoscopic examination. Overall, 23% of the cohort flared with median time to flare 90 (interquartile range, 67-117) days. Higher VAT:SAT was associated with shorter time to IBD flare (hazard ratio of 4.8 for VAT:SAT \u22651.0 vs VAT:SAT ratio &amp;lt;1.0), whereas higher BMI was not associated with shorter time to flare (hazard ratio of 0.73 for BMI \u226525 kg\/m2 vs BMI &amp;lt;25 kg\/m2). The relationship between increased VAT:SAT and shorter time to flare appeared stronger for Crohn\u2019s than for ulcerative colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Visceral adiposity was associated with decreased time to IBD flare, but BMI was not. Future studies could test whether interventions that decrease visceral adiposity will improve IBD disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izad111","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:52:11Z","timestamp":1686142331000},"page":"594-601","source":"Crossref","is-referenced-by-count":60,"title":["Visceral Adiposity Independently Predicts Time to Flare in Inflammatory Bowel Disease but Body Mass Index Does Not"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-2767","authenticated-orcid":false,"given":"Priya","family":"Sehgal","sequence":"first","affiliation":[{"name":"Division of Digestive and Liver Diseases, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medicine, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Zech","sequence":"additional","affiliation":[{"name":"Department of Radiology, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Nobel","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndon","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Radiology, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Economou","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E","family":"Freedberg","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, NewYork-Presbyterian\/Columbia University Irving Medical Center , New York, NY , 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