{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:46:40Z","timestamp":1782179200701,"version":"3.54.5"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:00:00Z","timestamp":1691193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011684","name":"Crohn\u2019s & Colitis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["U01 CA272977-01"],"award-info":[{"award-number":["U01 CA272977-01"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["U01 CA272977-01"],"award-info":[{"award-number":["U01 CA272977-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Individuals with ulcerative colitis (UC) seek complementary treatment methods, including diet and physical activity, to manage the burden of living with UC. This study examined associations between diet-associated inflammation, physical activity (PA), and UC-related health outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were obtained from 2052 IBD Partners e-cohort participants with UC. To quantify the inflammatory potential of food intake, dietary data were converted into Dietary Inflammatory Index (DII) and energy adjusted (E-DII) scores. Physical activity data were collected using the Godin-Shephard Leisure Time Activity Index. Outcome variables included the Simple Clinical Colitis Activity Index, Short Inflammatory Bowel Disease Questionnaire, and psychosocial PROMIS domains.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher E-DII scores, as indicator of increased dietary inflammatory potential, were associated with increased disease activity (\u03b2\u2005=\u20050.166; P &amp;lt; .001), anxiety (\u03b2\u2005=\u20050.342; P = .006), depression (\u03b2\u2005=\u20050.408; P = .004), fatigue (\u03b2\u2005=\u20050.386; P = .005), sleep disturbance (\u03b2\u2005=\u20050.339; P = .003), and decreased social satisfaction (\u03b2\u2005=\u2005-0.370; P = .004) and quality of life (\u03b2\u2005=\u2005\u22120.056; P &amp;lt; .001). Physical activity was inversely associated with disease activity (\u03b2\u2005=\u2005\u22120.108; P &amp;lt; .001), anxiety (\u03b2\u2005=\u2005\u22120.025; P = .001), depression (\u03b2\u2005=\u2005\u22120.025; P = .001), fatigue (\u03b2\u2005=\u2005\u22120.058; P &amp;lt; .001), and sleep disturbance (\u03b2\u2005=\u2005\u22120.019; P = .008), while positively associated with social satisfaction (\u03b2\u2005=\u20050.063; P &amp;lt; .001) and quality of life (\u03b2\u2005=\u20050.005; P &amp;lt; .001). Beneficial effects were generally greater for strenuous PA intensity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>An anti-inflammatory diet and increased PA are associated with decreased disease activity, anxiety symptoms, depression symptoms, and fatigue, and associated with improved quality of life, sleep, and social satisfaction for patients with UC. Such modalities may reduce the daily burden of illness and aid in managing systemic and localized inflammation associated with UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izad139","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T19:04:36Z","timestamp":1691262276000},"page":"273-280","source":"Crossref","is-referenced-by-count":19,"title":["Ulcerative Colitis Is Associated With Diet-related Inflammation and Physical Activity in the IBD Partners E-cohort"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-8845","authenticated-orcid":false,"given":"Kelli E","family":"DuBois","sequence":"first","affiliation":[{"name":"Prevention Research Center, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]},{"name":"Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E","family":"Blake","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rudisill","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayward E","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of South Carolina , Columbia, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Wirth","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]},{"name":"Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]},{"name":"Department of Nutrition, Connecting Health Innovations, LLC , Columbia, SC ,","place":["USA"]},{"name":"College of Nursing, University of South Carolina , Columbia SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]},{"name":"Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina , Columbia, SC ,","place":["USA"]},{"name":"Department of Nutrition, Connecting Health Innovations, LLC , Columbia, SC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,5]]},"reference":[{"issue":"F1000 Faculty Rev","key":"2025052401370759900_CIT0001","doi-asserted-by":"crossref","first-page":"294","DOI":"10.12688\/f1000research.20805.1","article-title":"Ulcerative colitis: recent advances in the understanding of disease pathogenesis","volume":"9","author":"Porter","year":"2020","journal-title":"F1000Research"},{"issue":"1","key":"2025052401370759900_CIT0002","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S2468-1253(19)30358-9","article-title":"Global burden of inflammatory bowel disease. 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