{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:52:23Z","timestamp":1790113943909,"version":"4.0.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>We sought to define the prevalence and to characterize possible predictive factors of Crohn\u2019s disease (CD) occurring in children with ulcerative colitis (UC) after ileal pouch\u2013anal anastomosis (IPAA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a multicenter, retrospective study including 15 centers of the Porto IBD group of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. Children with a confirmed diagnosis of UC undergoing colectomy with IPAA and a minimal follow up of 6 months were identified. The following data were collected: demographic data; endoscopic and histologic data; disease activity; laboratory exams; therapeutic history; indication for surgery, type, and timing; and IPAA functional outcomes and complications. In de novo CD cases, time of diagnosis, phenotype, location, and therapies were gathered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 111 UC children undergoing IPAA from January 2008 to June 2018 (median age at colectomy: 13 years; age range: 1-18 years; female\/male: 59\/52). The median time from diagnosis to colectomy was 16 (range, 0-202) months. At the last follow-up, 40 (36%) of 111 children developed pouchitis. The criteria for de novo CD were met in 19(17.1%) of 111 children with a 25-month median (range, 3-61 months). At last follow-up, 12 (63.1%) of 19 were treated with biologics and in 5 (26.3%) of 19 children, the pouch was replaced with definitive ileostomy. In a multivariable logistic regression model, decreased preoperative body mass index z scores (odds ratio, 2.2; 95% confidence interval, 1.1-4.4; P\u2005=\u2005.01) resulted as the only variable associated with CD development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Children with UC undergoing IPAA carry a high risk of developing subsequent CD. De novo CD cases showed decreased preoperative body mass index z scores, identifying a poor nutritional status as a possible predictive factor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izad199","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:48:29Z","timestamp":1696970909000},"page":"1475-1481","source":"Crossref","is-referenced-by-count":10,"title":["De Novo Crohn\u2019s Disease in Children With Ulcerative Colitis Undergoing Ileal Pouch\u2013Anal Anastomosis: A Multicenter, Retrospective Study From the Pediatric IBD Porto Group of the ESPGHAN"],"prefix":"10.1093","volume":"30","author":[{"given":"Massimo","family":"Martinelli","sequence":"first","affiliation":[{"name":"Section of Pediatrics, Department of Translational Medical Science, University of Naples Federico II , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminia","family":"Romeo","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy and Surgery Unit, Bambino Gesu Children\u2019s Hospital\u2013IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Caldaro","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy and Surgery Unit, Bambino Gesu Children\u2019s Hospital\u2013IRCCS , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Dimakou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, First Department of Pediatrics, Children\u2019s Hospital Agia Sofia, University of Athens , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, First Department of 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Romano","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina , Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Aloi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Department of Women\u2019s and Children\u2019s Health, Sapienza University , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Alvisi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Maggiore Hospital, Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"R\u00f6ser","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Hvidovre University Hospital , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaija Leena","family":"Kolho","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, University of Helsinki and HUS Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology, Southampton Children\u2019s Hospital , Southampton , United Kingdom"},{"name":"University of Portsmouth , Portsmouth , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-814X","authenticated-orcid":false,"given":"Oren","family":"Ledder","sequence":"additional","affiliation":[{"name":"Juliet Keidan institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Hebrew University , Jerusalem , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schlomi","family":"Cohen","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Institute, Dana-Dwek Children\u2019s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Bronsky","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Motol , Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C","family":"Escher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Erasmus MC-Sophia Children\u2019s Hospital , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annecarin","family":"Brueckner","sequence":"additional","affiliation":[{"name":"Dr. von Hauner Children\u2019s Hospital, Department of Pediatrics, University Hospital, Ludwig Maximilians University , Munich , 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