{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:53:32Z","timestamp":1787378012619,"version":"build-2736575974"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["66581437"],"award-info":[{"award-number":["66581437"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic inflammation in immune-mediated conditions has been associated with an increased risk in atherosclerotic disease. There is paucity of evidence regarding the prevalence of asymptomatic atherosclerosis in patients with ulcerative colitis (UC) and its association with disease activity. We sought to compare the prevalence of asymptomatic atherosclerotic disease between young patients with UC with and without mucosal healing (MH) and healthy control individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An observational study was conducted in 2 hospitals in Buenos Aires, Argentina. Patients with UC 18 to 50 years of age with at least 1 previous colonoscopy in the last year were enrolled, along with age- and sex-matched healthy control individuals. Carotid and femoral ultrasound assessments were performed to determine the prevalence of atherosclerotic lesions and abnormal intima-media thickness (IMT). We compared the prevalence of atherosclerotic disease and the prevalence of abnormally increased IMT in at least 1 vascular territory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Sixty patients with UC and 60 healthy control individuals were enrolled. Mean age was 38 years and 53.33% were men. Although the prevalence of atherosclerotic lesions was similar in patients with UC without MH when compared with both patients with UC with MH and control individuals (3.7% vs 0% vs 6.67%; P = .1), we found a significant increase in abnormal IMT in at least 1 vascular territory in UC patients without MH when compared with healthy control individuals (48.15% vs 26.67%; P = .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with UC with active mucosal inflammation showed a significantly increased odds of asymptomatic femoral or carotid vascular disease when compared with control individuals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izad217","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T20:41:31Z","timestamp":1695415291000},"page":"1654-1661","source":"Crossref","is-referenced-by-count":5,"title":["Endoscopically Active Ulcerative Colitis Is Associated With Asymptomatic Atherosclerotic Vascular Disease: A Case-Control Study"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-1659","authenticated-orcid":false,"given":"Juan","family":"Lasa","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Centro de Educaci\u00f3n M\u00e9dica e Investigaci\u00f3n Cl\u00ednica , Buenos Aires ,","place":["Argentina"]},{"name":"Gastroenterology Department, Hospital Brit\u00e1nico de Buenos Aires , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Nazario","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Brit\u00e1nico de Buenos Aires , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro de Educaci\u00f3n M\u00e9dica e Investigaci\u00f3n Cl\u00ednica , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Fern\u00e1ndez Recalde","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Brit\u00e1nico de Buenos Aires , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pereira","family":"Redondo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro de Educaci\u00f3n M\u00e9dica e Investigaci\u00f3n Cl\u00ednica , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Monta\u00f1ana","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro de Educaci\u00f3n M\u00e9dica e Investigaci\u00f3n Cl\u00ednica , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Spernanzoni","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro de Educaci\u00f3n M\u00e9dica e Investigaci\u00f3n Cl\u00ednica , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Zubiaurre","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Brit\u00e1nico de Buenos Aires , Buenos Aires ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-6102","authenticated-orcid":false,"given":"Pablo A","family":"Olivera","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro de Educaci\u00f3n M\u00e9dica e Investigaci\u00f3n Cl\u00ednica , Buenos Aires ,","place":["Argentina"]},{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld-Tanenbaum Research 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