{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:30:47Z","timestamp":1792621847884,"version":"4.5.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity, sarcopenia, and myosteatosis in inflammatory bowel disease may confer negative outcomes, but their prevalence and impact among patients with Crohn\u2019s disease (CD) have not been systematically studied. The aim of this study was to assess nutritional status and body composition among patients undergoing resectional surgery for CD and determine impact on operative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with CD undergoing resection from 2000 to 2018 were studied. Total, subcutaneous, and visceral fat areas and lean tissue area (LTA) and intramuscular adipose tissue (IMAT) were determined preoperatively by computed tomography at L3 using SliceOmatic (Tomovision, Canada). Univariable and multivariable linear, logistic, and Cox proportional hazards regression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred twenty-four consecutive patients were studied (ileocolonic disease 53%, n\u2005=\u200562, biologic therapy 34.4% n\u2005=\u200543). Mean fat mass was 22.7 kg, with visceral obesity evident in 23.9% (n\u2005=\u200527). Increased fat stores were associated with reduced risk of emergency presentation but increased corticosteroid use (\u03b2 9.09, standard error 3.49; P\u2005=\u2005.011). Mean LBM was 9.9 kg. Sarcopenia and myosteatosis were associated with impaired baseline nutritional markers. Myosteatosis markers IMAT (P\u2005=\u2005.002) and muscle attenuation (P\u2005=\u2005.0003) were associated with increased grade of complication. On multivariable analysis, IMAT was independently associated with increased postoperative morbidity (odds ratio [OR], 1.08; 95% confidence interval (CI), 1.01-1.16; P\u2005=\u2005.037) and comprehensive complications index (P\u2005=\u2005.029). Measures of adiposity were not associated with overall morbidity; however, increased visceral fat area independently predicted venous thromboembolism (OR, 1.02; 95% CI, 1.00-1.05; P\u2005=\u2005.028), and TFA was associated with increased wound infection (OR, 1.00; 95% CI, 1.00-1.01; P\u2005=\u2005.042) on multivariable analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Myosteatosis is associated with nutritional impairment and predicts increased overall postoperative morbidity following resection for CD. Despite its association with specific increased postoperative risks, increased adiposity does not increase overall morbidity, reflecting preservation of nutritional status and relatively more quiescent disease phenotype. Impaired muscle mass and function represent an appealing target for patient optimization to improve outcomes in the surgical management of CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izad225","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T10:12:42Z","timestamp":1694167962000},"page":"1517-1528","source":"Crossref","is-referenced-by-count":27,"title":["Obesity, Sarcopenia and Myosteatosis: Impact on Clinical Outcomes in the Operative Management of Crohn\u2019s Disease"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-3312","authenticated-orcid":false,"given":"Mark","family":"Donnelly","sequence":"first","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Driever","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-0836","authenticated-orcid":false,"given":"\u00c9anna J","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie A","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Finnegan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tallaght University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"McNamara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tallaght University Hospital , Dublin , Ireland"},{"name":"School of Medicine, Trinity College Dublin, The University of Dublin , Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tallaght University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C","family":"Conlon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"},{"name":"School of Medicine, Trinity College Dublin, The University of Dublin , Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C","family":"Neary","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"},{"name":"School of Medicine, Trinity College Dublin, The University of Dublin , Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara O","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"},{"name":"Royal College of Surgeons in Ireland, Department of Surgical Affairs , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"O\u2019Riordan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tallaght University Hospital , Dublin , Ireland"},{"name":"School of Medicine, Trinity College Dublin, The University of Dublin , Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"issue":"10114","key":"2024090305503750300_CIT0001","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet."},{"issue":"10","key":"2024090305503750300_CIT0002","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.cgh.2018.12.022","article-title":"Decreasing risk of first and subsequent surgeries in patients with Crohn\u2019s disease in England from 1994 through 2013","volume":"17","author":"Burr","year":"2019","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"15","key":"2024090305503750300_CIT0003","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab, azathioprine, or combination therapy for Crohn\u2019s disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N Engl J Med."},{"issue":"7","key":"2024090305503750300_CIT0004","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/ecco-jcc\/jjy040","article-title":"Colectomy rates in ulcerative colitis are low and decreasing: 10-year follow-up data from the Swiss IBD Cohort Study","volume":"12","author":"Parragi","year":"2018","journal-title":"J Crohns Colitis."},{"issue":"8","key":"2024090305503750300_CIT0005","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/apt.14930","article-title":"Short and long-term effectiveness and safety of vedolizumab in inflammatory bowel disease: results from the ENEIDA registry","volume":"48","author":"Chaparro","year":"2018","journal-title":"Aliment Pharmacol Ther."},{"issue":"1","key":"2024090305503750300_CIT0006","doi-asserted-by":"crossref","first-page":"9828","DOI":"10.1038\/s41598-017-10603-8","article-title":"Risk factors for postoperative surgical site infections in patients with Crohn\u2019s disease receiving definitive bowel resection","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep."},{"issue":"2","key":"2024090305503750300_CIT0007","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ajg.2016.541","article-title":"Postoperative complications after ileocecal resection in Crohn\u2019s disease: a Prospective Study From the REMIND Group","volume":"112","author":"Fumery","year":"2017","journal-title":"Am J Gastroenterol."},{"issue":"3","key":"2024090305503750300_CIT0008","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/ecco-jcc\/jju028","article-title":"Risk factors for postoperative intra-abdominal septic complications after surgery in Crohn\u2019s disease: a meta-analysis of observational studies","volume":"9","author":"Huang","year":"2015","journal-title":"J Crohns Colitis."},{"issue":"7","key":"2024090305503750300_CIT0009","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3109\/00365521.2016.1161069","article-title":"Body composition analysis using abdominal scans from routine clinical care in patients with Crohn\u2019s Disease","volume":"51","author":"Holt","year":"2016","journal-title":"Scand J Gastroenterol."},{"issue":"4","key":"2024090305503750300_CIT0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing."},{"issue":"60","key":"2024090305503750300_CIT0011","doi-asserted-by":"crossref","first-page":"102474","DOI":"10.18632\/oncotarget.19687","article-title":"Clinical significance of sarcopenia in the treatment of patients with primary hepatic malignancies, a systematic review and meta-analysis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget."},{"key":"2024090305503750300_CIT0012","doi-asserted-by":"crossref","first-page":"155533","DOI":"10.1016\/j.metabol.2023.155533","article-title":"Epidemiology of sarcopenia: prevalence, risk factors, and consequences","volume":"144","author":"Yuan","year":"2023","journal-title":"Metabolism."},{"key":"2024090305503750300_CIT0013","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3389\/fphys.2020.00963","article-title":"Myosteatosis in the context of skeletal muscle function deficit: an interdisciplinary Workshop at the National Institute on Aging","volume":"11","author":"Correa-de-Araujo","year":"2020","journal-title":"Front Physiol."},{"issue":"2","key":"2024090305503750300_CIT0014","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jamcollsurg.2010.03.039","article-title":"Sarcopenia and mortality after liver transplantation","volume":"211","author":"Englesbe","year":"2010","journal-title":"J Am Coll Surg."},{"issue":"8","key":"2024090305503750300_CIT0015","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1007\/s11605-012-1923-5","article-title":"Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinoma","volume":"16","author":"Peng","year":"2012","journal-title":"J Gastrointest Surg."},{"issue":"7","key":"2024090305503750300_CIT0016","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1477-2574.2011.00301.x","article-title":"Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis","volume":"13","author":"Peng","year":"2011","journal-title":"HPB (Oxford)."},{"issue":"6","key":"2024090305503750300_CIT0017","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jso.23862","article-title":"Sarcopenia is an independent predictor of complications following pancreatectomy for adenocarcinoma","volume":"111","author":"Joglekar","year":"2015","journal-title":"J Surg Oncol."},{"issue":"7","key":"2024090305503750300_CIT0018","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00268-012-1581-5","article-title":"Worsening central sarcopenia and increasing intra-abdominal fat correlate with decreased survival in patients with adrenocortical carcinoma","volume":"36","author":"Miller","year":"2012","journal-title":"World J Surg."},{"issue":"4","key":"2024090305503750300_CIT0019","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.arr.2010.05.005","article-title":"Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state","volume":"9","author":"Beenakker","year":"2010","journal-title":"Ageing Res Rev."},{"issue":"1","key":"2024090305503750300_CIT0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MCO.0b013e32834dd297","article-title":"Chronic low-grade inflammation and age-related sarcopenia","volume":"15","author":"Beyer","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"2024090305503750300_CIT0021","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1741-7015-9-48","article-title":"Metabolic syndrome: definition and controversies","volume":"9","author":"Kassi","year":"2011","journal-title":"BMC Med."},{"issue":"9468","key":"2024090305503750300_CIT0022","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet."},{"issue":"3","key":"2024090305503750300_CIT0023","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/apt.12372","article-title":"Systematic review: body composition in adults with inflammatory bowel disease","volume":"38","author":"Bryant","year":"2013","journal-title":"Aliment Pharmacol Ther."},{"issue":"7","key":"2024090305503750300_CIT0024","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/sj.ejcn.1601378","article-title":"Body composition in patients with an ileostomy and inflammatory bowel disease: validation of bio-electric impedance spectroscopy (BIS)","volume":"56","author":"Carlsson","year":"2002","journal-title":"Eur J Clin Nutr."},{"issue":"2","key":"2024090305503750300_CIT0025","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ajcn\/76.2.378","article-title":"Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method","volume":"76","author":"Kim","year":"2002","journal-title":"Am J Clin Nutr."},{"issue":"2","key":"2024090305503750300_CIT0026","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/ajcn\/59.2.325","article-title":"Critical assessment of body-composition measurements in malnourished subjects with Crohn\u2019s disease: the role of bioelectric impedance analysis","volume":"59","author":"Royall","year":"1994","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"2024090305503750300_CIT0027","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/ibd\/izy212","article-title":"Sarcopenia and inflammatory bowel disease: a systematic review","volume":"25","author":"Ryan","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"1","key":"2024090305503750300_CIT0028","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13244-021-01083-6","article-title":"Computed tomography-based multiple body composition parameters predict outcomes in Crohn\u2019s disease","volume":"12","author":"Zhou","year":"2021","journal-title":"Insights Imaging."},{"issue":"1","key":"2024090305503750300_CIT0029","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00054725-200002000-00002","article-title":"A simple classification of Crohn\u2019s disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998","volume":"6","author":"Gasche","year":"2000","journal-title":"Inflamm Bowel Dis."},{"key":"2024090305503750300_CIT0030","doi-asserted-by":"crossref","first-page":"5A","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can J Gastroenterol."},{"issue":"2","key":"2024090305503750300_CIT0031","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/ecco-jcc\/jjz187","article-title":"ECCO guidelines on therapeutics in Crohn\u2019s disease: surgical treatment","volume":"14","author":"Adamina","year":"2020","journal-title":"J Crohns Colitis."},{"issue":"2","key":"2024090305503750300_CIT0032","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg."},{"issue":"1","key":"2024090305503750300_CIT0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0b013e318296c732","article-title":"The comprehensive complication index: a novel continuous scale to measure surgical morbidity","volume":"258","author":"Slankamenac","year":"2013","journal-title":"Ann Surg."},{"issue":"5","key":"2024090305503750300_CIT0034","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","article-title":"A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care","volume":"33","author":"Mourtzakis","year":"2008","journal-title":"Appl Physiol Nutr Metab."},{"issue":"3","key":"2024090305503750300_CIT0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.nutres.2012.12.007","article-title":"Establishing computed tomography-defined visceral fat area thresholds for use in obesity-related cancer research","volume":"33","author":"Doyle","year":"2013","journal-title":"Nutr Res."},{"issue":"7","key":"2024090305503750300_CIT0036","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumors of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol."},{"issue":"4","key":"2024090305503750300_CIT0037","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0148607115612054","article-title":"Prevalence of sarcopenia and its impact on postoperative outcome in patients with Crohn\u2019s disease undergoing bowel resection","volume":"41","author":"Zhang","year":"2017","journal-title":"JPEN J Parenter Enteral Nutr."},{"issue":"10","key":"2024090305503750300_CIT0038","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1097\/MIB.0000000000001166","article-title":"Sarcopenia is a predictor of surgical morbidity in inflammatory bowel disease","volume":"23","author":"Pedersen","year":"2017","journal-title":"Inflamm Bowel Dis."},{"issue":"11","key":"2024090305503750300_CIT0039","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/ibd.20504","article-title":"Sarcopenia is prevalent in patients with Crohn\u2019s disease in clinical remission","volume":"14","author":"Schneider","year":"2008","journal-title":"Inflamm Bowel Dis."},{"issue":"11","key":"2024090305503750300_CIT0040","doi-asserted-by":"crossref","first-page":"O256","DOI":"10.1111\/codi.13067","article-title":"Sarcopenia, as defined by low muscle mass, strength and physical performance, predicts complications after surgery for colorectal cancer","volume":"17","author":"Huang","year":"2015","journal-title":"Colorectal Dis."},{"issue":"1","key":"2024090305503750300_CIT0041","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s41747-018-0072-3","article-title":"The impact of sarcopenia and myosteatosis on postoperative outcomes in patients with inflammatory bowel disease","volume":"2","author":"O\u2019Brien","year":"2018","journal-title":"Eur Radiol Exp."},{"issue":"6","key":"2024090305503750300_CIT0042","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00384-010-0902-0","article-title":"The benefit of an enhanced recovery programme following elective laparoscopic sigmoid colectomy","volume":"25","author":"Al Chalabi","year":"2010","journal-title":"Int J Colorectal Dis."},{"issue":"5","key":"2024090305503750300_CIT0043","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"issue":"2","key":"2024090305503750300_CIT0044","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcsm.12159","article-title":"Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: what are we really estimating","volume":"8","author":"Gonzalez","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle."},{"issue":"10","key":"2024090305503750300_CIT0045","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/oby.20346","article-title":"Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes","volume":"21","author":"Miljkovic","year":"2013","journal-title":"Obesity (Silver Spring)."},{"key":"2024090305503750300_CIT0046","doi-asserted-by":"crossref","first-page":"102839","DOI":"10.1016\/j.critrevonc.2019.102839","article-title":"Myosteatosis and prognosis in cancer: systematic review and meta-analysis","volume":"145","author":"Aleixo","year":"2020","journal-title":"Crit Rev Oncol Hematol."},{"issue":"31","key":"2024090305503750300_CIT0047","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"2024090305503750300_CIT0048","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4093\/dmj.2020.0277","article-title":"Computed tomography-derived myosteatosis and metabolic disorders","volume":"45","author":"Miljkovic","year":"2021","journal-title":"Diabetes Metab J."},{"issue":"2","key":"2024090305503750300_CIT0049","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/SLA.0000000000001113","article-title":"Low muscularity and myosteatosis is related to the host systemic inflammatory response in patients undergoing surgery for colorectal cancer","volume":"263","author":"Malietzis","year":"2016","journal-title":"Ann Surg."},{"issue":"2","key":"2024090305503750300_CIT0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"key":"2024090305503750300_CIT0051","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fnagi.2014.00192","article-title":"Sarcopenia and physical frailty: 2 sides of the same coin","volume":"6","author":"Cesari","year":"2014","journal-title":"Front Aging Neurosci."},{"issue":"4","key":"2024090305503750300_CIT0052","doi-asserted-by":"crossref","first-page":"371.e7","DOI":"10.1016\/j.jamda.2016.01.013","article-title":"Common ground? The concordance of sarcopenia and frailty definitions","volume":"17","author":"Reijnierse","year":"2016","journal-title":"J Am Med Dir Assoc."},{"issue":"1","key":"2024090305503750300_CIT0053","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jgo.2017.08.002","article-title":"Frailty and skeletal muscle in older adults with cancer","volume":"9","author":"Williams","year":"2018","journal-title":"J Geriatr Oncol."},{"issue":"5","key":"2024090305503750300_CIT0054","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/ajcn\/60.5.775","article-title":"Mechanisms of decreased food intake during weight loss in adult Crohn\u2019s disease patients without obvious malabsorption","volume":"60","author":"Rigaud","year":"1994","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"2024090305503750300_CIT0055","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/ibd.22965","article-title":"Dietary beliefs and behavior among inflammatory bowel disease patients","volume":"19","author":"Zallot","year":"2013","journal-title":"Inflamm Bowel Dis."},{"issue":"2","key":"2024090305503750300_CIT0056","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0261-5614(03)00132-8","article-title":"Dietary beliefs of people with ulcerative colitis and their effect on relapse and nutrient intake","volume":"23","author":"Jowett","year":"2004","journal-title":"Clin Nutr."},{"issue":"12","key":"2024090305503750300_CIT0057","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/ecco-jcc\/jjx102","article-title":"Prevalence of malnutrition and nutritional characteristics of patients with inflammatory bowel disease","volume":"11","author":"Casanova","year":"2017","journal-title":"J Crohns Colitis."},{"issue":"6","key":"2024090305503750300_CIT0058","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S2468-1253(23)00011-0","article-title":"Inflammation and malnutrition in inflammatory bowel disease","volume":"8","author":"Massironi","year":"2023","journal-title":"Lancet Gastroenterol Hepatol."},{"issue":"7","key":"2024090305503750300_CIT0059","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/MIB.0000000000001128","article-title":"Sarcopenia is common in overweight patients with inflammatory bowel disease and may predict need for surgery","volume":"23","author":"Adams","year":"2017","journal-title":"Inflamm Bowel Dis."},{"issue":"7","key":"2024090305503750300_CIT0060","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1016\/j.crohns.2012.09.009","article-title":"High prevalence of overweight and obesity in adults with Crohn\u2019s disease: associations with disease and lifestyle factors","volume":"7","author":"Nic Suibhne","year":"2013","journal-title":"J Crohns Colitis."},{"issue":"11","key":"2024090305503750300_CIT0061","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1111\/j.1572-0241.2007.01439.x","article-title":"A comprehensive approach to evaluate nutritional status in Crohn\u2019s patients in the era of biologic therapy: a case-control study","volume":"102","author":"Sousa Guerreiro","year":"2007","journal-title":"Am J Gastroenterol."},{"issue":"7","key":"2024090305503750300_CIT0062","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00384-022-04190-y","article-title":"Systematic review and meta-analysis: association between obesity\/overweight and surgical complications in IBD","volume":"37","author":"Jiang","year":"2022","journal-title":"Int J Colorectal Dis."},{"issue":"4","key":"2024090305503750300_CIT0063","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s11605-015-3060-4","article-title":"Obesity does not impact perioperative or postoperative outcomes in patients with inflammatory bowel disease","volume":"20","author":"Guardado","year":"2016","journal-title":"J Gastrointest Surg."},{"issue":"5","key":"2024090305503750300_CIT0064","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/SLA.0000000000002895","article-title":"The RESTORE randomized controlled trial: impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship","volume":"268","author":"O\u2019Neill","year":"2018","journal-title":"Ann Surg."},{"issue":"4","key":"2024090305503750300_CIT0065","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00003246-199504000-00012","article-title":"Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: an immunologic evaluation of Impact","volume":"23","author":"Kemen","year":"1995","journal-title":"Crit Care Med."},{"issue":"3","key":"2024090305503750300_CIT0066","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/SLA.0b013e31819a4789","article-title":"Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trial","volume":"249","author":"Ryan","year":"2009","journal-title":"Ann Surg."},{"issue":"9","key":"2024090305503750300_CIT0067","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/ibd\/izaa306","article-title":"Assessment of body composition from CT images at the level of the third lumbar vertebra in inflammatory bowel disease","volume":"27","author":"Bamba","year":"2021","journal-title":"Inflamm Bowel Dis."},{"issue":"1","key":"2024090305503750300_CIT0068","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.clnu.2007.10.008","article-title":"Fat-free mass and fat mass reference values by dual-energy X-ray absorptiometry (DEXA) in a 20-80 year-old Italian population","volume":"27","author":"Coin","year":"2008","journal-title":"Clin Nutr."},{"issue":"12","key":"2024090305503750300_CIT0069","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol."},{"issue":"2","key":"2024090305503750300_CIT0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41430-017-0034-5","article-title":"Percentiles for skeletal muscle index, area and radiation attenuation based on computed tomography imaging in a healthy Caucasian population","volume":"72","author":"van der Werf","year":"2018","journal-title":"Eur J Clin Nutr."},{"issue":"6","key":"2024090305503750300_CIT0071","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.juro.2010.08.007","article-title":"Early complications of cystectomy after high dose pelvic radiation","volume":"184","author":"Eisenberg","year":"2010","journal-title":"J Urol."},{"issue":"7","key":"2024090305503750300_CIT0072","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3390\/cancers13071745","article-title":"Clinical validation of the comprehensive complication index in colon cancer surgery","volume":"13","author":"Tamini","year":"2021","journal-title":"Cancers (Basel)."},{"issue":"2","key":"2024090305503750300_CIT0073","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4292\/wjgpt.v10.i2.50","article-title":"Nutritional status as a predictor of hospitalization in inflammatory bowel disease: a review","volume":"10","author":"Rocha","year":"2019","journal-title":"World J Gastrointest Pharmacol Ther."},{"issue":"2","key":"2024090305503750300_CIT0074","doi-asserted-by":"crossref","first-page":"e000823","DOI":"10.1136\/bmjopen-2012-000823","article-title":"Thirty-day mortality after elective and emergency total colectomy in Danish patients with inflammatory bowel disease: a population-based nationwide cohort study","volume":"2","author":"Tottrup","year":"2012","journal-title":"BMJ Open."},{"issue":"8","key":"2024090305503750300_CIT0075","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1001\/jamasurg.2017.0918","article-title":"Risk associated with complications and mortality after urgent surgery vs elective and emergency surgery: implications for defining \u201cquality\u201d and reporting outcomes for urgent surgery","volume":"152","author":"Mullen","year":"2017","journal-title":"JAMA Surg."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izad225\/52305217\/izad225.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/30\/9\/1517\/58843718\/izad225.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/30\/9\/1517\/58843718\/izad225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T01:51:21Z","timestamp":1725328281000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/30\/9\/1517\/7325269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":75,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,10,20]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izad225","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2023,10,20]]}}}