{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:03:36Z","timestamp":1788383016999,"version":"build-2803163510"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies investigated the risks of neurological conditions in patients with inflammatory bowel disease (IBD), with some variability in findings. We aimed to perform a systematic review and meta-analysis of available evidence to elucidate the association between IBD and the risks of common neurological disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a literature search through Embase, PubMed, Scopus, and ProQuest databases from inception to June 30, 2023, to identify cohort studies assessing the risk of developing stroke, all-cause dementia, Parkinson\u2019s disease (PD), multiple sclerosis (MS), seizure\/epilepsy, and peripheral neuropathy in adult IBD patients compared with non-IBD population. We combined hazard ratios (HRs) with 95% confidence intervals (CIs) to compute pooled estimates using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 22 cohort studies were included, of which 9 studies reported 7074 stroke events in 202 460 IBD patients, 5 studies reported 3783 all-cause dementia diagnoses in 109 602 IBD patients, 7 studies reported 932 PD diagnoses in 354 792 IBD patients, and 1 study reported 6 MS events in 35 581 IBD patients. We observed increased risks of incident stroke (pooled HR\u2005=\u20051.19; 95% CI, 1.06-1.31), all-cause dementia (pooled HR\u2005=\u20051.22; 95% CI, 1.05-1.38), PD (pooled HR\u2005=\u20051.39; 95% CI, 1.20-1.58), and MS (HR\u2005=\u20052.89; 95% CI, 1.02-8.42). No eligible studies were found on peripheral neuropathy and seizure\/epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inflammatory bowel disease may be modestly associated with increased risks of stroke, all-cause dementia, and PD. Further longitudinal studies are warranted to investigate potential links with MS, seizure\/epilepsy, and peripheral neuropathy, as well as their clinical significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izae012","type":"journal-article","created":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T08:03:43Z","timestamp":1704614623000},"page":"2195-2204","source":"Crossref","is-referenced-by-count":24,"title":["Risk of Common Neurological Disorders in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"30","author":[{"given":"Mohammad","family":"Zamani","sequence":"first","affiliation":[{"name":"Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Ebrahimtabar","sequence":"additional","affiliation":[{"name":"Neurology Department, Qazvin University of Medical Sciences , Qazvin ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Alizadeh-Tabari","sequence":"additional","affiliation":[{"name":"Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E","family":"Kasner","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S V","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University , New York, NY 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