{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:46:17Z","timestamp":1792280777728,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["RN279389-35803"],"award-info":[{"award-number":["RN279389-35803"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009776","name":"McMaster University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009776","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Calgary, University of Alberta"},{"DOI":"10.13039\/100008794","name":"Research Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003321","name":"Queen\u2019s University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003321","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002977","name":"Dalhousie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Montreal Heart Institute Research Centre"},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Allergan Incorporated"},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007658","name":"Crohn\u2019s and Colitis Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007658","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We aimed to establish a cohort of persons with Crohn\u2019s disease (CD) enrolled from 14 Canadian centers to describe the contemporary presentation of CD in Canada.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All enrollees were at least 18 years old and underwent chart review for phenotype documentation by Montreal Classification at time of enrollment, comorbidities, inflammatory bowel disease (IBD) and other surgeries, and use IBD and other therapies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 2112 adults, 59% were female, and the mean age was 44.1 (+\/-14.9SD) years. The phenotype distribution was B1\u2005=\u200550.4%, B2\u2005=\u200522.4%, B3\u2005=\u200517.3%, and missing information\u2005=\u20059.9%. Perineal disease was present in 14.2%. Pertaining to disease location, 35.2% of patients had disease in L1, 16.8% in L2, 48% in L3, and 0.4% in L4. There was no difference in phenotype by gender, anxiety score, depression score. Disease duration was significantly different depending on disease behavior type (B1\u2005=\u200512.2\u2005\u00b1\u200510.1; B2\u2005=\u200519.4\u2005\u00b1\u200512.9; B3\u2005=\u200518.9\u2005\u00b1\u200511.8, P\u2005&amp;lt;\u2005.0001). Isolated colonic disease was much less likely to be fibrostenotic or penetrating than inflammatory disease. Penetrating disease was more likely to be associated with ileocolonic location than other locations. Perineal disease was most commonly seen in persons with B3 disease behavior (24%) than other behaviors (11% B1; 20% B2 disease, P\u2005&amp;lt;\u2005.0001) and more likely to be seen in ileocolonic disease (L3;19%) vs L2 (17%) and L1 (11%; P\u2005&amp;lt;\u2005.0001). Surgery related to IBD occurred across each behavior types at the following rates: B1 = 23%, B2 = 64%, and B3 = 74%. Inflammatory bowel disease\u2013related surgery rates by location of disease were L1\u2005=\u200548%, L2\u2005=\u200521%, and L3\u2005=\u200551%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In exploring this large contemporary CD cohort we have determined that inflammatory disease is the main CD phenotype in Canada and that CD-related surgery remains very common.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izae055","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T22:21:18Z","timestamp":1711578078000},"page":"113-122","source":"Crossref","is-referenced-by-count":13,"title":["Crohn\u2019s Disease Phenotypes and Associations With Comorbidities, Surgery Risk, Medications and Nonmedication Approaches: The MAGIC in IMAGINE Study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3574","authenticated-orcid":false,"given":"Charles N","family":"Bernstein","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba ,","place":["Canada"]},{"name":"University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-940X","authenticated-orcid":false,"given":"Remo","family":"Panaccione","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Departments of Medicine, University of Calgary , Calgary, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoann","family":"Nugent","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba ,","place":["Canada"]},{"name":"University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-8008","authenticated-orcid":false,"given":"Deborah A","family":"Marshall","sequence":"additional","affiliation":[{"name":"Departments of Community Health Sciences, University of Calgary , Calgary, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilaad G","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Departments of Medicine, University of Calgary , Calgary, Alberta ,","place":["Canada"]},{"name":"Departments of Community Health Sciences, University of Calgary , Calgary, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Vanner","sequence":"additional","affiliation":[{"name":"Queens University , Kingston, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levinus A","family":"Dieleman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alberta , Edmonton, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A","family":"Graff","sequence":"additional","affiliation":[{"name":"University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada"},{"name":"Department of Clinical Health Psychology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Otley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dalhousie University , Halifax, Nova Scotia ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Buresi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Departments of Medicine, University of Calgary , Calgary, Alberta ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Murthy","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Borgaonkar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial University , St Johns, Newfoundland ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bressler","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of British Columbia , Vancouver, BC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bitton","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Croitoru","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto , Toronto, Ontario 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