{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:05:45Z","timestamp":1793066745169,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ocular manifestations (OMs) in patients with inflammatory bowel disease (IBD) are uncommon, particularly in children. We aimed to explore the prevalence and characteristics of IBD-associated OM in a large cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was performed using the Maccabi Healthcare Services (MHS) database. The eligible population included all patients diagnosed with IBD as children (&amp;lt;18 years) between January 2005 and July 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 2567 children with IBD (males 55%, Crohn\u2019s disease 64%), 78 (3%) were diagnosed with OM at any time during the disease course. In 54 patients (69%), the ocular disease occurred after IBD diagnosis with a median time of 2.6 (0.47-7) years between the 2 events, whereas in 24 patients (31%), ocular involvement preceded IBD diagnosis with a median time of 2.1 (0.6-5.7) years. The presence of ocular involvement was associated with increased usage of systemic corticosteroids (P &amp;lt; .001) and biologic agents (P = .04). There were 55 patients with ocular involvement during childhood who were ever diagnosed with IBD. In this population, ocular involvement was also associated with increased usage of systemic corticosteroids (P &amp;lt; .001). The prevalence of OM among patients with IBD did not change significantly over time (P = .75), with a prevalence of 2.3% at the end of the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of ocular involvement in children with IBD is rare and steady; it is also associated with a greater usage of systemic corticosteroids and biologic agents, potentially representing a more severe disease course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izae160","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:25:22Z","timestamp":1720052722000},"page":"1256-1262","source":"Crossref","is-referenced-by-count":7,"title":["The Prevalence and Characteristics of Inflammatory Bowel Disease-related Ocular Involvement in Children"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-7626","authenticated-orcid":false,"given":"Amir","family":"Ben-Tov","sequence":"first","affiliation":[{"name":"Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services , Tel Aviv ,","place":["Israel"]},{"name":"Pediatric Gastroenterology Institute, Dana-Dwek Children\u2019s Hospital , Tel Aviv ,","place":["Israel"]},{"name":"Faculty of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Achler","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Patalon","sequence":"additional","affiliation":[{"name":"Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Gazit","sequence":"additional","affiliation":[{"name":"Kahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-5271","authenticated-orcid":false,"given":"Henit","family":"Yanai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]},{"name":"IBD Center, Division of Gastroenterology, Rabin Medical Center , Petah Tikva ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiri","family":"Shulman","sequence":"additional","affiliation":[{"name":"Ophthalmology Institute, Assuta Medical Center , Tel Aviv ,","place":["Israel"]},{"name":"Faculty of health sciences, Ben-Gurion University of the Negev , Beer-Sheva 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