{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:22:18Z","timestamp":1787008938527,"version":"build-2736575974"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011684","name":"Crohn\u2019s & Colitis Foundation","doi-asserted-by":"crossref","award":["614963"],"award-info":[{"award-number":["614963"]}],"id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK127157"],"award-info":[{"award-number":["K23DK127157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK034987"],"award-info":[{"award-number":["P30DK034987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Development Award","award":["K23DK127241-01A1"],"award-info":[{"award-number":["K23DK127241-01A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Lay Summary<\/jats:title>\n                  <jats:p>In this prospective, multicenter observational study of highly refractory patients with Crohn\u2019s disease of the pouch, risankizumab achieved the primary outcome of clinical remission in 50% and the more stringent secondary outcome of antibiotic- and steroid-free remission in 30.8% at 12 weeks.<\/jats:p>","DOI":"10.1093\/ibd\/izae164","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:25:23Z","timestamp":1720052723000},"page":"878-881","source":"Crossref","is-referenced-by-count":8,"title":["Risankizumab Is Effective for The Management of Crohn\u2019s Disease of the Pouch"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-950X","authenticated-orcid":false,"given":"Maia","family":"Kayal","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, The Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6787-1164","authenticated-orcid":false,"given":"Elizabeth A","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Smyth","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-2592","authenticated-orcid":false,"given":"Laura","family":"Raffals","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6770-9055","authenticated-orcid":false,"given":"Taha","family":"Qazi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-9784","authenticated-orcid":false,"given":"Parakkal","family":"Deepak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Washington University School of Medicine in St . Louis, St. Louis, MO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Beniwal-Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Medical College of Wisconsin , Milwaukee, WI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, NYU Langone Health , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Higgins","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Michigan , Ann Arbor, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond K","family":"Cross","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Anderson","sequence":"additional","affiliation":[{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina , Chapel Hill, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millie","family":"Long","sequence":"additional","affiliation":[{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina , Chapel Hill, NC ,","place":["USA"]},{"name":"Division of Gastroenterology and Hepatology, University of North Carolina , Chapel Hill, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans H","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina , Chapel Hill, NC ,","place":["USA"]},{"name":"Division of Gastroenterology and Hepatology, University of North Carolina , Chapel Hill, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-5795","authenticated-orcid":false,"given":"Marla C","family":"Dubinsky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L","family":"Barnes","sequence":"additional","affiliation":[{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina , Chapel Hill, NC ,","place":["USA"]},{"name":"Division of Gastroenterology and Hepatology, University of North Carolina , Chapel Hill, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"issue":"9","key":"2025030423095494900_CIT0001","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1093\/ibd\/izz005","article-title":"The incidence and definition of Crohn\u2019s disease of the pouch: a systematic review and meta-analysis","volume":"25","author":"Barnes","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"3","key":"2025030423095494900_CIT0002","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cgh.2017.06.016","article-title":"Natural history of adult ulcerative colitis in population-based cohorts: a systematic review","volume":"16","author":"Fumery","year":"2018","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"1","key":"2025030423095494900_CIT0003","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1053\/j.gastro.2023.10.015","article-title":"AGA clinical practice guideline on the management of pouchitis and inflammatory pouch disorders","volume":"166","author":"Barnes","year":"2024","journal-title":"Gastroenterology."},{"issue":"3","key":"2025030423095494900_CIT0004","doi-asserted-by":"publisher","first-page":"584","DOI":"10.14309\/ajg.0000000000002599","article-title":"Changes in therapy are not associated with increased remission in patients with Crohn\u2019s disease of the pouch","volume":"119","author":"Kayal","year":"2024","journal-title":"Am J Gastroenterol."},{"issue":"3","key":"2025030423095494900_CIT0005","doi-asserted-by":"publisher","first-page":"otac030","DOI":"10.1093\/crocol\/otac030","article-title":"Treatment patterns and standardized outcome assessments among patients with Inflammatory conditions of the pouch in a prospective multicenter registry","volume":"4","author":"Barnes","year":"2022","journal-title":"Crohns Colitis 360."},{"issue":"1","key":"2025030423095494900_CIT0006","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S2468-1253(21)00214-4","article-title":"Treatment of pouchitis, Crohn\u2019s disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium","volume":"7","author":"Shen","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"10340","key":"2025030423095494900_CIT0007","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/S0140-6736(22)00467-6","article-title":"Risankizumab as induction therapy for Crohn\u2019s disease: results from the phase 3 ADVANCE and MOTIVATE induction trials","volume":"399","author":"D\u2019Haens","year":"2022","journal-title":"Lancet."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izae164\/58610302\/izae164.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/3\/878\/58610302\/izae164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/3\/878\/58610302\/izae164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T18:10:49Z","timestamp":1741111849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/31\/3\/878\/7718025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,7,22]]},"published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izae164","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2024,7,22]]}}}