{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:40:10Z","timestamp":1790894410378,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect of overweight and obesity at the start of anti-TNF therapy on treatment response and relapse rate in children with inflammatory bowel disease (IBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, retrospective cohort study included 22 IBD centers in 14 countries. Children diagnosed with IBD in whom antitumor necrosis factor (anti-TNF) was introduced were included; those who were overweight\/obese were compared with children who were well\/undernourished.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six hundred thirty-seven children (370 [58%] males; mean age 11.5\u2005\u00b1\u20053.5 years) were included; 140 (22%) were in the overweight\/obese group (OG) and 497 (78%) had BMI \u22641 SD (CG). The mean follow-up time was 141\u2005\u00b1\u200578 weeks (median 117 weeks). There was no difference in the loss of response (LOR) to anti-TNF between groups throughout the follow-up. However, children in OG had more dose escalations than controls. Male sex and lack of concomitant immunomodulators at the start of anti-TNF were risk factors associated with the LOR. There was no difference in the relapse rate in the first year after anti-TNF introduction; however, at the end of the follow-up, the relapse rate was significantly higher in the OG compared with CG (89 [64%] vs 218 [44%], respectively, P &amp;lt; .001). Univariate and multivariate analysis revealed that being overweight\/obese, having UC, or being of male sex were factors associated with a higher risk for relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overweight\/obese children with IBD were not at a higher risk of LOR to anti-TNF. Relapse in the first year after anti-TNF was introduced, but risk for relapse was increased at the end of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izae165","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T16:29:05Z","timestamp":1720110545000},"page":"1263-1271","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Overweight and Obesity on the Response to Anti-TNF Therapy and Disease Course in Children With IBD"],"prefix":"10.1093","volume":"31","author":[{"given":"Sara","family":"Sila","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital Zagreb, University of Zagreb Medical School , Zagreb ,","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-2279","authenticated-orcid":false,"given":"Marina","family":"Aloi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit, Sapienza University\u2013Umberto 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