{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:09:37Z","timestamp":1751515777682,"version":"3.41.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK127157"],"award-info":[{"award-number":["K23DK127157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The value of histologic assessment after ileal pouch-anal anastomosis (IPAA) has not been definitively determined. We evaluated the correlation between histology and endoscopic findings, as well as the proportion of patients with inflammation in areas beyond the pouch body on their initial pouchoscopy after IPAA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a retrospective cohort study, we evaluated patients who underwent IPAA for UC between 2012 and 2020 and subsequently underwent a pouchoscopy with routine biopsies of the pouch body, pre-pouch ileum, and rectal cuff. We compared endoscopic and histologic assessments in each location using \u03c72 testing and Spearman correlation, as well as the development of pouchitis and Crohn\u2019s-like disease of the pouch (CLDP) in longitudinal follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 126 patients, the median time to pouchoscopy after IPAA was 384 days, with 82 patients (65%) having inflammation of the pouch body. Significantly more patients with pouch body inflammation had histologic inflammation compared with patients without pouch body inflammation (96% vs 22%, P\u2005&amp;lt;\u2005.001, r\u2005=\u20050.769). Additionally, 16 patients (13%) were found to have endoscopic inflammation of the pre-pouch ileum with corresponding histologic inflammation in 88%; of these, 31% later developed CLDP. In contrast, 13% of patients with no endoscopic inflammation displayed histologic inflammation, with none later developing CLDP. Forty-six percent of patients had rectal cuff inflammation (correlation with histologic inflammation r\u2005=\u20050.580).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our evaluation, the added benefit of histology in the presence of visible endoscopic inflammation for disease activity assessment scores is unclear. The prognostic value of histologic inflammation without endoscopic inflammation warrants a longitudinal study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izae175","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:55:29Z","timestamp":1723074929000},"page":"1514-1519","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Value of Histology and Anatomic Segment Evaluation Among Patients Undergoing Pouchoscopy"],"prefix":"10.1093","volume":"31","author":[{"given":"Mili","family":"Dave","sequence":"first","affiliation":[{"name":"University of North Carolina School of Medicine , Chapel Hill, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-823X","authenticated-orcid":false,"given":"Hans H","family":"Herfarth","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]},{"name":"Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]},{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-8796","authenticated-orcid":false,"given":"Edward L","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]},{"name":"Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]},{"name":"Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill , Chapel Hill, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"issue":"1","key":"2025070211121877300_CIT0001","doi-asserted-by":"publisher","first-page":"174","DOI":"10.14309\/ajg.0000000000002013","article-title":"Histologic activity in an endoscopically normal-appearing pouch predicts future risk of pouchitis in patients with ulcerative colitis","volume":"118","author":"Gupta","year":"2023","journal-title":"Am J Gastroenterol."},{"issue":"11","key":"2025070211121877300_CIT0002","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1093\/ibd\/izac277","article-title":"Histologic predictors of clinical outcomes and healthcare utilization in patients with ileal pouch anal anastomosis","volume":"29","author":"Chang","year":"2023","journal-title":"Inflamm Bowel Dis."},{"issue":"S1","key":"2025070211121877300_CIT0003","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1097\/DCR.0000000000002553","article-title":"Histopathology of pouch and para-pouch inflammatory and neoplastic disorders","volume":"65","author":"Ballentine","year":"2022","journal-title":"Dis Colon Rectum."},{"issue":"10","key":"2025070211121877300_CIT0004","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1016\/j.cgh.2020.10.039","article-title":"Contemporary risk of surgery in patients with ulcerative colitis and Crohn\u2019s disease: a meta-analysis of population-based cohorts","volume":"19","author":"Tsai","year":"2021","journal-title":"Clin Gastroenterol 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A long-term follow-up study","volume":"13","author":"Setti Carraro","year":"1998","journal-title":"Int J Colorectal Dis."},{"key":"2025070211121877300_CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.012","article-title":"Antibiotic use in the 12 months prior to ileal pouch-anal anastomosis increases the risk for pouchitis","author":"Barnes","year":"2024","journal-title":"Clin Gastroenterol Hepatol."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izae175\/58758790\/izae175.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/6\/1514\/58758790\/izae175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/6\/1514\/58758790\/izae175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:12:26Z","timestamp":1751469146000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/31\/6\/1514\/7729104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,8,7]]},"published-print":{"date-parts":[[2025,6,13]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izae175","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"type":"print","value":"1078-0998"},{"type":"electronic","value":"1536-4844"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2024,8,7]]}}}