{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:14:57Z","timestamp":1780467297542,"version":"3.54.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Aage and Johann Louis-Hansens Foundation"},{"DOI":"10.13039\/501100003035","name":"Aase and Ejnar Danielsens Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pediatric-onset ulcerative colitis (pUC) represents a more aggressive disease phenotype compared with adult-onset UC. We hypothesized that this difference can, in part, be explained by the composition of the microbiota.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a prospective, longitudinal study, we included pediatric (N\u2005=\u200530) and adult (N\u2005=\u200530) patients with newly or previously (&amp;gt;1 year) diagnosed UC. We analyzed the microbiota composition in the mucosa-adherent microbiota at baseline, using 16S rRNA gene sequencing, and the fecal microbiota at baseline and at 3-month intervals, using shotgun metagenomics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For fecal samples, the bacterial composition differed between pUC and aUC in newly diagnosed patients (\u03b2-diversity, Bray Curtis: R2\u2005=\u20050.08, P\u2005=\u2005.02). In colon biopsies, microbial diversity was higher in aUC compared with pUC (\u03b1-diversity, Shannon: estimated difference 0.54, P\u2005=\u2005.006). In the mucosa-adherent microbiota, Alistipes finegoldii was negatively associated with disease activity in pUC while being positively associated in aUC (estimate: \u22120.255 and 0.098, P\u2005=\u2005.003 and P\u2005=\u2005.02 in pUC and aUC, respectively). Finally, we showed reduced stability of the fecal microbiota in pediatric patients, evidenced by a different composition of the fecal microbiota in newly and previously diagnosed pUC, a pattern not found in adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results indicate that pediatric UC patients have a more unstable fecal microbiota and a lower \u03b1 diversity than adult patients and that the microbiota composition differs between aUC and pUC patients. These findings offer some explanation for the observed differences between pUC and aUC and indicate that individualized approaches are needed if microbiota modifications are to be used in the future treatment of UC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izae179","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T18:02:14Z","timestamp":1723831334000},"page":"501-513","source":"Crossref","is-referenced-by-count":5,"title":["The Composition of the Fecal and Mucosa-adherent Microbiota Varies Based on Age and Disease Activity in Ulcerative Colitis"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-7676","authenticated-orcid":false,"given":"Mikkel","family":"Malham","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Copenhagen University Hospital\u2013Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Copenhagen Center for Inflammatory Bowel 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Christian-Albrechts-University of Kiel , 24105 Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Line","family":"Engsbro","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital\u2013Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Copenhagen University Hospital\u2013Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Copenhagen University Hospital\u2013Amager and Hvidovre , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel , 24105 Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Wewer","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Copenhagen University Hospital\u2013Amager and Hvidovre , Hvidovre ,","place":["Denmark"]},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents, and Adults, Copenhagen University Hospital\u2013Amager and Hvidovre , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise B","family":"Thingholm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel , 24105 Kiel ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas M","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Copenhagen University Hospital\u2013Amager 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