{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:47:46Z","timestamp":1766587666741,"version":"3.37.3"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Seoul National University Bundang Hospital Research Fund","award":["2022-03808"],"award-info":[{"award-number":["2022-03808"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Growing interest exists in deep remission, beyond clinical and endoscopic remission, to enhance long-term prognosis in patients with ulcerative colitis (UC). Our study aimed to evaluate the risk of relapse according to tissue expression levels of calprotectin and neutrophil elastase (NE) in patients with quiescent UC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Rectal biopsies were performed on 218 patients with UC in clinical and endoscopic remission. Histological activity was prospectively scored using the Robarts Histological Index. Tissue calprotectin and NE levels were evaluated using immunohistochemistry. Optimal tissue calprotectin and NE cutoffs for relapse were determined using log-rank analysis. Cox proportional hazard analyses evaluated relapse risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Tissue calprotectin and NE levels were significantly higher in patients with histological activity than in those in histological remission (P\u2005&amp;lt;\u2005.001). The optimal cutoffs of tissue calprotectin and NE for relapse were 10.61 and 22.08 per mm2, respectively. The 3-year clinical relapse risk was significantly lower in the low-tissue NE group than in the high-tissue NE group (P\u2005=\u2005.009); however, it did not differ between the low- and high-tissue calprotectin group (P\u2005=\u2005.094). In multivariate analyses, a low level of tissue NE expression was independently associated with a lower risk of 3-year clinical relapse (adjusted hazard ratio\u2005=\u20050.453, 95% confidence interval\u2005=\u20050.225\u20130.911, P\u2005=\u2005.026), unlike histological index and tissue calprotectin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with UC who have achieved clinical and endoscopic remission, tissue expression of NE is a better predictor of long-term relapse than histological activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izae194","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T01:44:19Z","timestamp":1724809459000},"page":"514-523","source":"Crossref","is-referenced-by-count":1,"title":["The Potential of Molecular Remission: Tissue Neutrophil Elastase Is Better Than Histological Activity for Predicting Long-Term Relapse in Patients With Ulcerative Colitis in Endoscopic Remission"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-8578","authenticated-orcid":false,"given":"Yu Kyung","family":"Jun","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital , Seongnam,","place":["South Korea"]},{"name":"Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine , Seoul,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-3988","authenticated-orcid":false,"given":"Hyeon Jeong","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University Bundang Hospital , Seongnam,","place":["South 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