{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:06:19Z","timestamp":1792415179435,"version":"4.4.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psychiatric disorders in patients with inflammatory bowel disease (IBD) represent a significant but uncertain facet of the disease, with unsolved questions regarding their overall magnitude, their impact on intestinal disease, and the whole burden of psychiatric manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review summarizes the evidence on the prevalence and impact of psychiatric disorders, including depression, anxiety, bipolar disorder (BD), and schizophrenia, among patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search across PubMed\/MEDLINE, Embase, and Scopus databases from January 2010 to January 2023 was performed to identify relevant studies. The focus was on studies exploring the prevalence of specific psychiatric disorders in IBD patients compared to the general population and that reported specific outcome measures. A subsequent meta-analysis (MA) assessed the strength of the association between IBD and these psychiatric disorders, with data reliability ensured through rigorous extraction and quality assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 3,209 articles, 193 met the inclusion criteria and only 26 provided complete data for comprehensive analysis. These studies showed a significantly higher overall prevalence of psychiatric comorbidities in IBD patients compared to the general population. The MA showed a significant association between IBD and depression (pooled OR 1.42, 95% CI\u2005=\u20051.33-1.52, P\u2005&amp;lt;\u2005.0001) and anxiety (pooled OR 1.3, 95% CI\u2005=\u20051.22-1.44, P\u2005&amp;lt;\u2005.0001). The association between IBD and BD was significant (pooled OR 1.64, 95% CI\u2005=\u20051.20-2.24, P\u2005&amp;lt;\u2005.0001) but showed considerable heterogeneity (I2\u2005=\u200594.01%). Only 3 studies examined the association between schizophrenia and IBD, providing widely heterogeneous results, with an inconclusive OR, estimated at 0.93 (95% CI\u2005=\u20050.62-1.39, P\u2005=\u2005.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This MA highlights the high prevalence of psychiatric disorders, particularly depression and anxiety, in IBD patients, which exceeds rates in the general population. BD in IBD is proving to be an important but under-researched area. The sparse and contradictory data on schizophrenia requires further investigation. These findings highlight the need for better understanding, early detection, and tailored mental health interventions in the management of IBD to significantly improve patients\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izae206","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T20:13:13Z","timestamp":1724357593000},"page":"1441-1459","source":"Crossref","is-referenced-by-count":56,"title":["The Burden of Psychiatric Manifestations in Inflammatory Bowel Diseases: A Systematic Review With Meta-analysis"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-8192","authenticated-orcid":false,"given":"Sara","family":"Massironi","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Monza ,","place":["Italy"]},{"name":"Division of Gastroenterology, Fondazione IRCCS San Gerardo dei Tintori , Monza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pigoni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Anna Maria","family":"Vegni","sequence":"additional","affiliation":[{"name":"Department of Mental Health, ASST Santi Paolo e Carlo , Milan ,","place":["Italy"]},{"name":"Department of Health Sciences, University of Milan , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-8593","authenticated-orcid":false,"given":"Laurie","family":"Keefer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Icahn School of Medicine at Mount Sinai , New York City, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marla C","family":"Dubinsky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Icahn School of Medicine , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-8456","authenticated-orcid":false,"given":"Paolo","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico , Milan ,","place":["Italy"]},{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Delvecchio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-1351","authenticated-orcid":false,"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital , Milan ,","place":["Italy"]},{"name":"School of Medicine, Vita-Salute San Raffaele University , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"issue":"1","key":"2025051304061800500_CIT0001","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S2468-1253(19)30358-9","article-title":"Global burden of inflammatory bowel disease","volume":"5","author":"Jairath","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"6","key":"2025051304061800500_CIT0002","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/17474124.2023.2209723","article-title":"Psychological distress in inflammatory bowel disease","volume":"17","author":"Balestrieri","year":"2023","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"12","key":"2025051304061800500_CIT0003","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1002\/ibd.22916","article-title":"Mood disorders in inflammatory bowel disease: relation to diagnosis, disease activity, perceived stress, and other factors","volume":"18","author":"Goodhand","year":"2012","journal-title":"Inflamm Bowel Dis."},{"issue":"3","key":"2025051304061800500_CIT0004","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S2468-1253(16)30206-0","article-title":"Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis","volume":"2","author":"Gracie","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"5","key":"2025051304061800500_CIT0005","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S2468-1253(21)00014-5","article-title":"Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"6","key":"2025051304061800500_CIT0006","doi-asserted-by":"publisher","first-page":"527","DOI":"10.5223\/pghn.2019.22.6.527","article-title":"Burden of psychiatric disorders among pediatric and young adults with inflammatory bowel disease: a population-based analysis","volume":"22","author":"Thavamani","year":"2019","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"issue":"10","key":"2025051304061800500_CIT0007","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1111\/apt.16820","article-title":"Antidepressant medication use in inflammatory bowel disease: a nationally representative population-based study","volume":"55","author":"Jayasooriya","year":"2022","journal-title":"Aliment Pharmacol Ther."},{"issue":"1","key":"2025051304061800500_CIT0008","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/ibd\/izad062","article-title":"Increased risks for suicide, self-harm, substance use, and psychiatric disorders in adults with inflammatory bowel disease: a Nationwide Study in the United States from 2007 to 2017","volume":"30","author":"Tse","year":"2023","journal-title":"Inflamm Bowel Dis."},{"issue":"10","key":"2025051304061800500_CIT0009","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1001\/jamapediatrics.2019.2662","article-title":"Association of childhood-onset inflammatory bowel disease with risk of psychiatric disorders and suicide attempt","volume":"173","author":"Butwicka","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"12","key":"2025051304061800500_CIT0010","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/ibd.21298","article-title":"Inflammatory bowel disease and completed suicide in Danish adults","volume":"16","author":"Gradus","year":"2010","journal-title":"Inflamm Bowel Dis."},{"issue":"6","key":"2025051304061800500_CIT0011","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1399-5618.2010.00853.x","article-title":"Autoimmune diseases, bipolar disorder, and non-affective psychosis","volume":"12","author":"Eaton","year":"2010","journal-title":"Bipolar Disord."},{"issue":"2","key":"2025051304061800500_CIT0012","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/ibd.21346","article-title":"Anxiety and depression in patients with inflammatory bowel disease: comparisons with chronic liver disease patients and the general population","volume":"17","author":"H\u00e4user","year":"2011","journal-title":"Inflamm Bowel Dis."},{"issue":"10","key":"2025051304061800500_CIT0013","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1097\/HJH.0000000000002517","article-title":"Anxiety, depression, chronic inflammation and aortic stiffness in Crohn\u2019s disease: the brain-gut-vascular axis","volume":"38","author":"Zanoli","year":"2020","journal-title":"J Hypertens."},{"issue":"1","key":"2025051304061800500_CIT0014","doi-asserted-by":"publisher","first-page":"48","DOI":"10.24869\/psyd.2021.48","article-title":"Anxiety, depression and personality types in patients with inflammatory bowel disease: comparisons with peptic ulcer and the general population","volume":"33","author":"Babi\u0107","year":"2021","journal-title":"Psychiatr Danub."},{"issue":"4","key":"2025051304061800500_CIT0015","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/ibd\/izad109","article-title":"Association of depression with incident inflammatory bowel diseases: a systematic review and meta-analysis","volume":"30","author":"Piovani","year":"2023","journal-title":"Inflamm Bowel Dis."},{"issue":"Jul-Aug","key":"2025051304061800500_CIT0016","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.genhosppsych.2023.05.002","article-title":"The bidirectional risk of inflammatory bowel disease and anxiety or depression: a systematic review and meta-analysis","volume":"83","author":"Bisgaard","year":"2023","journal-title":"Gen Hosp Psychiatry."},{"issue":"9","key":"2025051304061800500_CIT0017","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1080\/17474124.2021.1911644","article-title":"Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review","volume":"15","author":"Dubinsky","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"3","key":"2025051304061800500_CIT0018","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/MIB.0000000000000620","article-title":"Controversies revisited: a systematic review of the comorbidity of depression and anxiety with inflammatory bowel diseases","volume":"22","author":"Mikocka-Walus","year":"2016","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025051304061800500_CIT0019","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1007\/s12325-023-02473-6","article-title":"Epidemiological, clinical, patient-reported and economic burden of inflammatory bowel disease (ulcerative colitis and Crohn\u2019s disease) in Spain: a systematic review","volume":"40","author":"Barreiro-de Acosta","year":"2023","journal-title":"Adv Ther."},{"issue":"3","key":"2025051304061800500_CIT0020","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/apt.14171","article-title":"Systematic review with meta-analysis: the impact of a depressive state on disease course in adult inflammatory bowel disease","volume":"46","author":"Alexakis","year":"2017","journal-title":"Aliment Pharmacol Ther."},{"issue":"6","key":"2025051304061800500_CIT0021","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/ajg.2016.98","article-title":"Association between affective-cognitive symptoms of depression and exacerbation of Crohn\u2019s disease","volume":"111","author":"Gaines","year":"2016","journal-title":"Am J Gastroenterol."},{"issue":"6","key":"2025051304061800500_CIT0022","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.cgh.2015.12.045","article-title":"Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease","volume":"14","author":"Mikocka-Walus","year":"2016","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"11","key":"2025051304061800500_CIT0023","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1093\/ecco-jcc\/jjab039","article-title":"Association between inflammatory bowel disease and psychiatric morbidity and suicide: a Swedish Nationwide Population-Based Cohort Study with sibling comparisons","volume":"15","author":"Ludvigsson","year":"2021","journal-title":"J Crohns Colitis."},{"issue":"Aug","key":"2025051304061800500_CIT0024","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","article-title":"Depression and anxiety in patients with inflammatory bowel disease: a systematic review","volume":"87","author":"Neuendorf","year":"2016","journal-title":"J Psychosom Res."},{"issue":"5","key":"2025051304061800500_CIT0025","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/apt.14865","article-title":"Systematic review with meta-analysis: anxiety and depression in children and adolescents with inflammatory bowel disease","volume":"48","author":"Stapersma","year":"2018","journal-title":"Aliment Pharmacol Ther."},{"issue":"May 5","key":"2025051304061800500_CIT0026","doi-asserted-by":"publisher","first-page":"101986","DOI":"10.1016\/j.eclinm.2023.101986","article-title":"Longitudinal trajectories of anxiety, depression, and bipolar disorder in inflammatory bowel disease: a population-based cohort study","volume":"59","author":"Bisgaard","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"6","key":"2025051304061800500_CIT0027","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1007\/s12035-022-02800-y","article-title":"Inflammation and nitro-oxidative stress as drivers of endocannabinoid system aberrations in mood disorders and schizophrenia","volume":"59","author":"Morris","year":"2022","journal-title":"Mol Neurobiol."},{"issue":"6","key":"2025051304061800500_CIT0028","doi-asserted-by":"publisher","first-page":"e13593","DOI":"10.1111\/nmo.13593","article-title":"Aberrant brain structural large-scale connectome in Crohn\u2019s disease","volume":"31","author":"Thomann","year":"2019","journal-title":"Neurogastroenterol Motil."},{"issue":"Feb 26","key":"2025051304061800500_CIT0029","doi-asserted-by":"publisher","first-page":"1359540","DOI":"10.3389\/fimmu.2024.1359540","article-title":"Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications","volume":"15","author":"Li","year":"2024","journal-title":"Front Immunol."},{"issue":"Oct 8","key":"2025051304061800500_CIT0030","doi-asserted-by":"publisher","first-page":"714057","DOI":"10.3389\/fpsyt.2021.714057","article-title":"Depression and anxiety disorders in patients with inflammatory bowel disease","volume":"12","author":"Hu","year":"2021","journal-title":"Front Psychiatry."},{"issue":"10","key":"2025051304061800500_CIT0031","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/s2468-1253(23)00186-3","article-title":"Efficacy of psychological therapies in people with inflammatory bowel disease: a systematic review and meta-analysis","volume":"8","author":"Riggott","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"Mar 29","key":"2025051304061800500_CIT0032","doi-asserted-by":"publisher","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"Jan 30","key":"2025051304061800500_CIT0033","doi-asserted-by":"publisher","first-page":"k4597","DOI":"10.1136\/bmj.k4597","article-title":"A guide to systematic review and meta-analysis of prognostic factor studies","volume":"364","author":"Riley","year":"2019","journal-title":"BMJ"},{"issue":"10","key":"2025051304061800500_CIT0034","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1177\/1049732312452938","article-title":"Beyond PICO: the SPIDER tool for qualitative evidence synthesis","volume":"22","author":"Cooke","year":"2012","journal-title":"Qual Health Res."},{"issue":"1","key":"2025051304061800500_CIT0035","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1398-9995.2009.02142.x","article-title":"Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids","volume":"65","author":"Aceves","year":"2010","journal-title":"Allergy."},{"issue":"9","key":"2025051304061800500_CIT0036","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol."},{"key":"2025051304061800500_CIT0037","volume-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-analyses.","author":"Wells","year":"2021"},{"issue":"May-Jun","key":"2025051304061800500_CIT0038","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.genhosppsych.2023.03.002","article-title":"Inflammatory bowel disease and the long-term risk of depression: a prospective cohort study of the UK biobank","volume":"82","author":"Ma","year":"2023","journal-title":"Gen Hosp Psychiatry."},{"issue":"5","key":"2025051304061800500_CIT0039","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3390\/jcm8050654","article-title":"Risk of anxiety and depression in patients with inflammatory bowel disease: a Nationwide, Population-Based Study","volume":"8","author":"Choi","year":"2019","journal-title":"J Clin Med"},{"issue":"2","key":"2025051304061800500_CIT0040","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00384-021-04056-9","article-title":"Burden of depression and anxiety among patients with inflammatory bowel disease: results of a nationwide analysis","volume":"37","author":"Tarar","year":"2022","journal-title":"Int J Colorectal Dis."},{"issue":"5","key":"2025051304061800500_CIT0041","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/apt.17110","article-title":"The association between inflammatory bowel disease and mental ill health: a retrospective cohort study using data from UK primary care","volume":"56","author":"Umar","year":"2022","journal-title":"Aliment Pharmacol Ther."},{"issue":"7","key":"2025051304061800500_CIT0042","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/jgh.15855","article-title":"Bidirectional association between inflammatory bowel disease and depression among patients and their unaffected siblings","volume":"37","author":"Zhang","year":"2022","journal-title":"J Gastroenterol Hepatol."},{"issue":"9","key":"2025051304061800500_CIT0043","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1136\/gutjnl-2020-322308","article-title":"Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case-control study","volume":"70","author":"Blackwell","year":"2021","journal-title":"Gut."},{"issue":"9","key":"2025051304061800500_CIT0044","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1136\/gutjnl-2018-317610","article-title":"Inflammatory bowel disease and new-onset psychiatric disorders in pregnancy and post partum: a population-based cohort study","volume":"68","author":"Vigod","year":"2019","journal-title":"Gut."},{"issue":"4","key":"2025051304061800500_CIT0045","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s12664-018-0870-9","article-title":"Psychiatric comorbidities in patients with inflammatory bowel disease","volume":"37","author":"Bhamre","year":"2018","journal-title":"Indian J Gastroenterol."},{"issue":"2","key":"2025051304061800500_CIT0046","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/ibd\/izy235","article-title":"Increased burden of psychiatric disorders in inflammatory bowel disease","volume":"25","author":"Bernstein","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"2025051304061800500_CIT0047","doi-asserted-by":"publisher","first-page":"512","DOI":"10.5009\/gnl16347","article-title":"Association of inflammatory bowel disease (IBD) with depressive symptoms in the United States population and independent predictors of depressive symptoms in an IBD population: a NHANES Study","volume":"11","author":"Bhandari","year":"2017","journal-title":"Gut Liver"},{"issue":"Jul-Aug","key":"2025051304061800500_CIT0048","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.genhosppsych.2018.06.001","article-title":"Psychiatric comorbidity increases mortality in immune-mediated inflammatory diseases","volume":"53","author":"Marrie","year":"2018","journal-title":"Gen Hosp Psychiatry."},{"issue":"Mar-Apr","key":"2025051304061800500_CIT0049","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.genhosppsych.2018.01.003","article-title":"Physical comorbidities increase the risk of psychiatric comorbidity in immune-mediated inflammatory disease","volume":"51","author":"Marrie","year":"2018","journal-title":"Gen Hosp Psychiatry."},{"issue":"9","key":"2025051304061800500_CIT0050","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/ajg.2011.142","article-title":"Increased risks of developing anxiety and depression in young patients with Crohn\u2019s disease","volume":"106","author":"Loftus","year":"2011","journal-title":"Am J Gastroenterol."},{"issue":"3","key":"2025051304061800500_CIT0051","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/ebmental-2020-300223","article-title":"Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study","volume":"24","author":"Irving","year":"2021","journal-title":"Evid Based Ment Health."},{"issue":"12","key":"2025051304061800500_CIT0052","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/jgh3.12836","article-title":"Depression is associated with increased disease activity in patients with ulcerative colitis: a propensity score-matched analysis using a nationwide database in Japan","volume":"6","author":"Oyama","year":"2022","journal-title":"JGH Open"},{"issue":"4","key":"2025051304061800500_CIT0053","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/ibd\/izab136","article-title":"Depressive symptoms predict clinical recurrence of inflammatory bowel disease","volume":"28","author":"Jordi","year":"2022","journal-title":"Inflamm Bowel Dis."},{"issue":"2","key":"2025051304061800500_CIT0054","doi-asserted-by":"publisher","first-page":"304","DOI":"10.14309\/ajg.0000000000002063","article-title":"Characteristics and effect of anxiety and depression trajectories in inflammatory bowel disease","volume":"118","author":"Fairbrass","year":"2023","journal-title":"Am J Gastroenterol."},{"issue":"3","key":"2025051304061800500_CIT0055","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/apt.14832","article-title":"Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease","volume":"48","author":"van den Brink","year":"2018","journal-title":"Aliment Pharmacol Ther."},{"issue":"12","key":"2025051304061800500_CIT0056","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.dld.2017.08.020","article-title":"Symptoms of anxiety and depression are independently associated with inflammatory bowel disease-related disability","volume":"49","author":"Chan","year":"2017","journal-title":"Dig Liver Dis."},{"key":"2025051304061800500_CIT0057","doi-asserted-by":"publisher","first-page":"6496727","DOI":"10.1155\/2017\/6496727","article-title":"Prevalence of anxiety and depression in patients with inflammatory bowel disease","volume":"2017","author":"Byrne","year":"2017","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"10","key":"2025051304061800500_CIT0058","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1097\/MIB.0000000000000518","article-title":"Robust association between inflammatory bowel disease and generalized anxiety disorder: findings from a Nationally Representative Canadian Study","volume":"21","author":"Fuller-Thomson","year":"2015","journal-title":"Inflamm Bowel Dis."},{"issue":"11","key":"2025051304061800500_CIT0059","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1093\/ibd\/izy143","article-title":"Influences and impact of anxiety and depression in the setting of inflammatory bowel disease","volume":"24","author":"Navabi","year":"2018","journal-title":"Inflamm Bowel Dis."},{"issue":"7","key":"2025051304061800500_CIT0060","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1093\/ibd\/izy385","article-title":"Anxiety but not depression predicts poor outcomes in inflammatory bowel disease","volume":"25","author":"Narula","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025051304061800500_CIT0061","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/ibd\/izab162","article-title":"Anxiety and depressive symptoms are not associated with future pediatric Crohn\u2019s disease activity","volume":"28","author":"Brenner","year":"2022","journal-title":"Inflamm Bowel Dis."},{"issue":"9","key":"2025051304061800500_CIT0062","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/ibd\/izaa310","article-title":"The impact of psychiatric comorbidity on health care utilization in inflammatory bowel disease: a population-based study","volume":"27","author":"Bernstein","year":"2021","journal-title":"Inflamm Bowel Dis."},{"issue":"Mar 15","key":"2025051304061800500_CIT0063","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jad.2019.01.014","article-title":"Inflammatory bowel disease and bipolar disorder: a population-based cross-sectional study","volume":"247","author":"Kao","year":"2019","journal-title":"J Affect Disord."},{"issue":"9","key":"2025051304061800500_CIT0064","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1001\/jamainternmed.2015.3540","article-title":"Nationwide population science: lessons from the Taiwan national health insurance research database","volume":"175","author":"Hsing","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"Dec 23","key":"2025051304061800500_CIT0065","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/1741-7015-11-263","article-title":"Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study","volume":"11","author":"Smith","year":"2013","journal-title":"BMC Med."},{"issue":"Mar 6","key":"2025051304061800500_CIT0066","doi-asserted-by":"publisher","first-page":"17562848231155022","DOI":"10.1177\/17562848231155022","article-title":"Effect of antidepressants on psychological comorbidities, disease activity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis","volume":"16","author":"Wang","year":"2023","journal-title":"Therap Adv Gastroenterol"},{"issue":"1","key":"2025051304061800500_CIT0067","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ibd\/izz104","article-title":"The cost of inflammatory bowel disease: an initiative from the Crohn\u2019s & Colitis foundation","volume":"26","author":"Park","year":"2020","journal-title":"Inflamm Bowel Dis."},{"issue":"13","key":"2025051304061800500_CIT0068","doi-asserted-by":"publisher","first-page":"6255","DOI":"10.3390\/ijerph20136255","article-title":"Depressive and anxiety disorders in patients with inflammatory bowel diseases: are there any gender differences","volume":"20","author":"Fracas","year":"2023","journal-title":"Int J Environ Res Public Health."},{"issue":"Oct 13","key":"2025051304061800500_CIT0069","doi-asserted-by":"publisher","first-page":"1267834","DOI":"10.3389\/fimmu.2023.1267834","article-title":"Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study","volume":"14","author":"Yang","year":"2023","journal-title":"Front Immunol."},{"issue":"9","key":"2025051304061800500_CIT0070","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1093\/ibd\/izz032","article-title":"Initial assessment of post-traumatic stress in a US cohort of inflammatory bowel disease patients","volume":"25","author":"Taft","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025051304061800500_CIT0071","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1093\/ibd\/izac148","article-title":"Hospitalization experiences and post-traumatic stress in inflammatory bowel disease: opportunities for change","volume":"29","author":"Taft","year":"2023","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025051304061800500_CIT0072","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/ibd\/izab152","article-title":"Posttraumatic stress in patients with inflammatory bowel disease: prevalence and relationships to patient-reported outcomes","volume":"28","author":"Taft","year":"2022","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"2025051304061800500_CIT0073","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/apt.12195","article-title":"Psychiatric co-morbidity is associated with increased risk of surgery in Crohn\u2019s disease","volume":"37","author":"Ananthakrishnan","year":"2013","journal-title":"Aliment Pharmacol Ther."},{"issue":"5","key":"2025051304061800500_CIT0074","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S2468-1253(21)00066-2","article-title":"What can we do to tackle anxiety and depression in patients with inflammatory bowel disease","volume":"6","author":"Keefer","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"6","key":"2025051304061800500_CIT0075","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.cgh.2020.07.013","article-title":"Anxiety and depression leads to anti-tumor necrosis factor discontinuation in inflammatory bowel disease","volume":"19","author":"Dolovich","year":"2021","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"12","key":"2025051304061800500_CIT0076","first-page":"588","article-title":"Screening for depression in patients with inflammatory bowel disease","volume":"17","author":"Keefer","year":"2021","journal-title":"Gastroenterol Hepatol (N Y)"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izae206\/59107353\/izae206.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/5\/1441\/59107353\/izae206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/5\/1441\/59107353\/izae206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T04:06:24Z","timestamp":1747109184000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/31\/5\/1441\/7756413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":76,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,9,12]]},"published-print":{"date-parts":[[2025,5,12]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izae206","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2024,9,12]]}}}