{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:07:47Z","timestamp":1790474867572,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007028","name":"The Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with ulcerative colitis (UC) undergoing proctocolectomy and ileal pouch\u2013anal anastomosis (IPAA) may eventually require biologic therapy. Factors associated with biologic therapy after IPAA have not been previously studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients with UC after total proctocolectomy and IPAA who were followed at Rabin Medical Center comprehensive pouch clinic and who consented to prospective observational follow-up were included. The primary outcome was the initiation of biologic therapy after IPAA. Cox proportional hazard models were used to evaluate potential associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 400 patients receiving their care at the pouch clinic, 148 patients consented to prospective observational follow-up and constituted the study cohort. The median age at diagnosis was 21 years and the age at IPAA was 30 years. Median time-to-biologic therapy initiation post-IPAA was 9.2 years, with 34 patients (23%) initiating biologic therapy: Associated factors for initiating biologic therapy post-IPAA were preoperative treatment with biologic therapy and immunomodulatory therapy (hazard ratio [HR] 6.1 and 3.6, respectively, P\u2005&amp;lt;\u2005.001); Arab descent (HR 5.3, P\u2005&amp;lt;\u2005.001); heterozygosity of NOD2 variant rs2066845 (HR 5.1, P\u2005=\u2005.03); past smoking status (HR 2.3, P\u2005=\u2005.03); 3-stage IPAA (HR 2.3, P\u2005=\u2005.02); immediate postoperative complications (HR 2.1, P\u2005=\u2005.033); and pediatric-onset UC (HR 2.1, P\u2005=\u2005.03). None of the patients undergoing IPAA due to dysplasia (n\u2005=\u200527) required biologic therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Several demographic, disease-related, surgery-related, and genetic factors associated with post-IPAA biologic therapy were identified. Physicians treating patients with UC undergoing colectomy should incorporate these factors into their decision-making process. These patients may benefit from closer postoperative follow-up, and earlier initiation of biologic therapy should be considered.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izae272","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:30:58Z","timestamp":1731583858000},"page":"1934-1942","source":"Crossref","is-referenced-by-count":2,"title":["Factors Associated With Biologic Therapy After Ileal Pouch\u2013Anal Anastomosis in Patients With Ulcerative Colitis"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8191-055X","authenticated-orcid":false,"given":"Maya","family":"Fischman","sequence":"first","affiliation":[{"name":"Department of Military Medicine, Faculty of Medicine, Hebrew University of Jerusalem , Jerusalem,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-6466","authenticated-orcid":false,"given":"Lihi","family":"Godny","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Friedenberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital","family":"Barkan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"White","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]},{"name":"Division of Surgery, Rabin Medical Center , Petah-Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Wasserberg","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]},{"name":"Division of Surgery, Rabin Medical Center , Petah-Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University , Petah-Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Avni-Biron","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar","family":"Banai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Snir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Broitman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-5271","authenticated-orcid":false,"given":"Henit","family":"Yanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Dotan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-0699","authenticated-orcid":false,"given":"Jacob E","family":"Ollech","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center , Petah Tikva,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"issue":"3","key":"2025070803374526400_CIT0001","doi-asserted-by":"publisher","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG clinical guideline: ulcerative colitis in adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am J Gastroenterol."},{"issue":"Suppl 3","key":"2025070803374526400_CIT0002","doi-asserted-by":"publisher","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"Lamb","year":"2019","journal-title":"Gut."},{"issue":"2","key":"2025070803374526400_CIT0003","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/DCR.0b013e3182753e10","article-title":"Long-term functional and quality-of-life outcomes after IPAA in children","volume":"56","author":"Zmora","year":"2013","journal-title":"Dis Colon Rectum."},{"issue":"6","key":"2025070803374526400_CIT0004","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1007\/DCR.0b013e3181d98d66","article-title":"A longitudinal study of quality of life and functional outcome of patients with ulcerative colitis after proctocolectomy with ileal pouch-anal anastomosis","volume":"53","author":"Tulchinsky","year":"2010","journal-title":"Dis Colon Rectum."},{"issue":"1","key":"2025070803374526400_CIT0005","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/ecco-jcc\/jjx112","article-title":"Long-term risk of cancer following ileal pouch-anal anastomosis for ulcerative colitis","volume":"12","author":"Mark-Christensen","year":"2018","journal-title":"J Crohns Colitis."},{"issue":"4","key":"2025070803374526400_CIT0006","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1097\/SLA.0b013e31827d99a2","article-title":"Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients","volume":"257","author":"Fazio","year":"2013","journal-title":"Ann Surg."},{"issue":"6","key":"2025070803374526400_CIT0007","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1002\/ibd.20378","article-title":"Guidelines for the management of growth failure in childhood inflammatory bowel disease","volume":"14","author":"Heuschkel","year":"2008","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025070803374526400_CIT0008","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/apt.14205","article-title":"The outcome of ulcerative colitis patients undergoing pouch surgery is determined by pre-surgical factors","volume":"46","author":"Yanai","year":"2017","journal-title":"Aliment Pharmacol Ther."},{"issue":"8","key":"2025070803374526400_CIT0009","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1016\/j.cgh.2021.11.012","article-title":"Fecal calprotectin is increased in pouchitis and progressively increases with more severe endoscopic and histologic disease","volume":"20","author":"Ollech","year":"2022","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"7","key":"2025070803374526400_CIT0010","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1093\/ibd\/izab209","article-title":"Long-term antibiotic treatment in pouchitis\u2014patterns of use and safety","volume":"28","author":"Bar","year":"2022","journal-title":"Inflamm Bowel Dis."},{"issue":"2","key":"2025070803374526400_CIT0011","doi-asserted-by":"publisher","first-page":"367","DOI":"10.14309\/ajg.0000000000002038","article-title":"Fecal calprotectin and quality of life questionnaires are responsive to change in pouch disease activity after antibiotic therapy: results from a prospective clinical trial","volume":"118","author":"Ollech","year":"2023","journal-title":"Am J Gastroenterol."},{"issue":"5","key":"2025070803374526400_CIT0012","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1093\/ibd\/izy020","article-title":"Management of pouchitis and other common complications of the pouch","volume":"24","author":"Dalal","year":"2018","journal-title":"Inflamm Bowel Dis."},{"issue":"1","key":"2025070803374526400_CIT0013","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1053\/j.gastro.2023.10.015","article-title":"AGA clinical practice guideline on the management of pouchitis and inflammatory pouch disorders","volume":"166","author":"Barnes","year":"2024","journal-title":"Gastroenterology."},{"issue":"2","key":"2025070803374526400_CIT0014","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/ibd.21037","article-title":"Efficacy of infliximab in refractory pouchitis and Crohn\u2019s disease-related complications of the pouch: a Belgian case series","volume":"16","author":"Ferrante","year":"2010","journal-title":"Inflamm Bowel Dis."},{"issue":"13","key":"2025070803374526400_CIT0015","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1056\/NEJMoa2208450","article-title":"Vedolizumab for the treatment of chronic pouchitis","volume":"388","author":"Travis","year":"2023","journal-title":"N Engl J Med."},{"issue":"12","key":"2025070803374526400_CIT0016","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1007\/s10620-019-05697-1","article-title":"Ustekinumab is effective for the treatment of chronic antibiotic-refractory pouchitis","volume":"64","author":"Ollech","year":"2019","journal-title":"Dig Dis Sci."},{"issue":"4","key":"2025070803374526400_CIT0017","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/ibd\/izy302","article-title":"Ustekinumab is effective for the treatment of Crohn\u2019s disease of the pouch in a multicenter cohort","volume":"25","author":"Weaver","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025070803374526400_CIT0018","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/ibd.21821","article-title":"Efficacy of infliximab rescue therapy in patients with chronic refractory pouchitis: a multicenter study","volume":"18","author":"Barreiro-de Acosta","year":"2012","journal-title":"Inflamm Bowel Dis."},{"issue":"10","key":"2025070803374526400_CIT0019","doi-asserted-by":"publisher","first-page":"e457","DOI":"10.1016\/j.crohns.2013.02.018","article-title":"Long term benefit of one year infliximab administration for the treatment of chronic refractory pouchitis","volume":"7","author":"Viazis","year":"2013","journal-title":"J Crohns Colitis."},{"issue":"10","key":"2025070803374526400_CIT0020","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1046\/j.1365-2036.2003.01535.x","article-title":"Infliximab in refractory pouchitis complicated by fistulae following ileo-anal pouch for ulcerative colitis","volume":"17","author":"Viscido","year":"2003","journal-title":"Aliment Pharmacol Ther."},{"issue":"5","key":"2025070803374526400_CIT0021","first-page":"239","article-title":"Management of refractory fistulizing pouchitis with infliximab","volume":"8","author":"Viscido","year":"2004","journal-title":"Eur Rev Med Pharmacol Sci."},{"issue":"11","key":"2025070803374526400_CIT0022","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1111\/j.1463-1318.2012.02993.x","article-title":"Risk factors for chronic pouchitis after ileal pouch\u2013anal anastomosis: a prospective cohort study","volume":"14","author":"Hashavia","year":"2012","journal-title":"Colorectal Dis."},{"issue":"9","key":"2025070803374526400_CIT0023","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.dld.2021.03.027","article-title":"Chronic pouchitis and Crohn\u2019s disease of the pouch after ileal pouch-anal anastomosis: Incidence and risk factors","volume":"53","author":"Bresteau","year":"2021","journal-title":"Dig Liver Dis."},{"issue":"1","key":"2025070803374526400_CIT0024","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cgh.2005.10.004","article-title":"Risk factors for diseases of ileal pouch\u2013anal anastomosis after restorative proctocolectomy for ulcerative colitis","volume":"4","author":"Shen","year":"2006","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"2","key":"2025070803374526400_CIT0025","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1136\/gut.38.2.234","article-title":"Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis","volume":"38","author":"Penna","year":"1996","journal-title":"Gut."},{"issue":"6","key":"2025070803374526400_CIT0026","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1007\/s10620-012-2050-6","article-title":"ASCA IgG and CBir antibodies are associated with the development of Crohn\u2019s disease and fistulae following ileal pouch-anal anastomosis","volume":"57","author":"Coukos","year":"2012","journal-title":"Dig Dis Sci."},{"issue":"9","key":"2025070803374526400_CIT0027","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/apt.12274","article-title":"Meta-analysis: serological markers and the risk of acute and chronic pouchitis","volume":"37","author":"Singh","year":"2013","journal-title":"Aliment Pharmacol Ther."},{"issue":"12","key":"2025070803374526400_CIT0028","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1093\/ibd\/izad039","article-title":"Acute severe ulcerative colitis is associated with an increased risk of acute pouchitis","volume":"29","author":"Kayal","year":"2023","journal-title":"Inflamm Bowel Dis."},{"issue":"8","key":"2025070803374526400_CIT0029","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.cgh.2020.06.035","article-title":"Incidence, risk factors, and outcomes of pouchitis and pouch-related complications in patients with ulcerative colitis","volume":"19","author":"Barnes","year":"2021","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"11","key":"2025070803374526400_CIT0030","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1097\/DCR.0000000000001467","article-title":"Exposure to anti-tumor necrosis factor medications increases the incidence of pouchitis after restorative proctocolectomy in patients with ulcerative colitis","volume":"62","author":"Bertucci Zoccali","year":"2019","journal-title":"Dis Colon Rectum."},{"issue":"10","key":"2025070803374526400_CIT0031","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1097\/MIB.0000000000000487","article-title":"Serology of patients with ulcerative colitis after pouch surgery is more comparable with that of patients with Crohn\u2019s disease","volume":"21","author":"Goren","year":"2015","journal-title":"Inflamm Bowel Dis."},{"issue":"2","key":"2025070803374526400_CIT0032","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ng1954","article-title":"A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1","volume":"39","author":"Hampe","year":"2007","journal-title":"Nat Genet."},{"issue":"3","key":"2025070803374526400_CIT0033","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3109\/08820139.2014.988721","article-title":"Association between CARD8 rs2043211 polymorphism and inflammatory bowel disease: a meta-analysis","volume":"44","author":"Liu","year":"2015","journal-title":"Immunol Invest."},{"issue":"9","key":"2025070803374526400_CIT0034","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1093\/ibd\/izz016","article-title":"The unsolved link of genetic markers and Crohn\u2019s disease progression: a North American cohort experience","volume":"25","author":"O\u2019Donnell","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"1","key":"2025070803374526400_CIT0035","doi-asserted-by":"publisher","first-page":"2024415","DOI":"10.1080\/19490976.2021.2024415","article-title":"Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease","volume":"14","author":"Sharma","year":"2022","journal-title":"Gut Microbes"},{"issue":"6837","key":"2025070803374526400_CIT0036","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature."},{"issue":"11","key":"2025070803374526400_CIT0037","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/DCR.0b013e3181f22635","article-title":"NOD2\/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis","volume":"53","author":"Sehgal","year":"2010","journal-title":"Dis Colon Rectum."},{"issue":"10","key":"2025070803374526400_CIT0038","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1136\/gutjnl-2011-301957","article-title":"The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis","volume":"62","author":"Tyler","year":"2013","journal-title":"Gut."},{"issue":"6837","key":"2025070803374526400_CIT0039","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature."},{"issue":"6","key":"2025070803374526400_CIT0040","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/gene.2008.49","article-title":"Confirmation of association of IRGM and NCF4 with ileal Crohn\u2019s disease in a population-based cohort","volume":"9","author":"Roberts","year":"2008","journal-title":"Genes Immun."},{"issue":"4","key":"2025070803374526400_CIT0041","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1053\/j.gastro.2016.06.040","article-title":"Genetic complexity of Crohn\u2019s disease in two large Ashkenazi Jewish families","volume":"151","author":"Levine","year":"2016","journal-title":"Gastroenterology."},{"issue":"2","key":"2025070803374526400_CIT0042","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/ng.3755","article-title":"Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn\u2019s disease","volume":"49","author":"Lee","year":"2017","journal-title":"Nat Genet."},{"issue":"4","key":"2025070803374526400_CIT0043","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1053\/j.gastro.2008.06.081","article-title":"Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease","volume":"135","author":"Van Limbergen","year":"2008","journal-title":"Gastroenterology."},{"issue":"6","key":"2025070803374526400_CIT0044","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.3390\/jpm13061008","article-title":"Ethnic issues and disparities in inflammatory bowel diseases: what can we learn from the Arab population in Israel","volume":"13","author":"Abu-Freha","year":"2023","journal-title":"J Pers Med"},{"issue":"7","key":"2025070803374526400_CIT0045","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1097\/MIB.0000000000001119","article-title":"Pouch-related symptoms and quality of life in patients with ileal pouch\u2013anal anastomosis","volume":"23","author":"Barnes","year":"2017","journal-title":"Inflamm Bowel Dis."},{"issue":"9","key":"2025070803374526400_CIT0046","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1093\/ibd\/izz005","article-title":"The incidence and definition of Crohn\u2019s disease of the pouch: a systematic review and meta-analysis","volume":"25","author":"Barnes","year":"2019","journal-title":"Inflamm Bowel Dis."},{"issue":"7","key":"2025070803374526400_CIT0047","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1093\/ibd\/izz227","article-title":"Inflammatory pouch conditions are common after ileal pouch anal anastomosis in ulcerative colitis patients","volume":"26","author":"Kayal","year":"2020","journal-title":"Inflamm Bowel Dis."},{"issue":"5","key":"2025070803374526400_CIT0048","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1463-1318.2009.01816.x","article-title":"Long-term failure and function after restorative proctocolectomy\u2014a multi-centre study of patients from the UK National Ileal Pouch Registry","volume":"12","author":"Tekkis","year":"2010","journal-title":"Colorectal Dis."},{"issue":"2","key":"2025070803374526400_CIT0049","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cgh.2021.02.010","article-title":"Endoscopic phenotype of the J Pouch in patients with inflammatory bowel disease: a new classification for pouch outcomes","volume":"20","author":"Akiyama","year":"2022","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"5","key":"2025070803374526400_CIT0050","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/s0025-6196(12)61634-6","article-title":"Pouchitis after ileal pouch-anal anastomosis: a pouchitis disease activity index","volume":"69","author":"Sandborn","year":"1994","journal-title":"Mayo Clin Proc."},{"issue":"2","key":"2025070803374526400_CIT0051","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.gie.2018.04.2330","article-title":"Reliability among central readers in the evaluation of endoscopic disease activity in pouchitis","volume":"88","author":"Samaan","year":"2018","journal-title":"Gastrointest Endosc."},{"issue":"11-12","key":"2025070803374526400_CIT0052","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1111\/apt.15505","article-title":"Endoscopic activity in asymptomatic patients with an ileal pouch is associated with an increased risk of pouchitis","volume":"50","author":"Kayal","year":"2019","journal-title":"Aliment Pharmacol Ther."},{"key":"2025070803374526400_CIT0053","doi-asserted-by":"publisher","first-page":"S1542-3565(24)00636","DOI":"10.1016\/j.cgh.2024.06.037","article-title":"Mucosal healing with vedolizumab in patients with chronic pouchitis: EARNEST, a randomized, double-blind, placebo-controlled trial","author":"Jairath","year":"2024","journal-title":"Clin Gastroenterol Hepatol."}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izae272\/60669184\/izae272.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/7\/1934\/60669184\/izae272.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/7\/1934\/60669184\/izae272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:37:52Z","timestamp":1751960272000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/31\/7\/1934\/7900199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,11,14]]},"published-print":{"date-parts":[[2025,7,7]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izae272","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2024,11,14]]}}}