{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:22:19Z","timestamp":1787008939711,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Takeda Israel Ltd","award":["IISR-2017-102336"],"award-info":[{"award-number":["IISR-2017-102336"]}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Small bowel video capsule endoscopy (SB-VCE) assesses mucosal inflammation in Crohn\u2019s disease (CD), while intestinal ultrasound (IUS) examines transmural involvement. We aimed to correlate SB-VCE with IUS in evaluating active CD and monitoring treatment response over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with active SB-CD who initiated biologics were prospectively followed with fecal calprotectin (FC), SB-VCE, and IUS at baseline and after 14 and 52 weeks. The Lewis score (LS), Limberg index (LI), and terminal ileum bowel wall thickness (TI-BWT) were documented, and the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS) was retrospectively calculated. Biochemical, endoscopic, and ultrasonographic remission were defined as FC\u2005&amp;lt;\u2005150 \u03bcg\/g, LS\u2005&amp;lt;\u2005135, and LI\u2005&amp;lt;\u20052\u2005+\u2005TI-BWT\u2005\u2264\u20053 mm, respectively. A therapeutic response for each index was defined as a 25% reduction compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy-one patients were included (median age: 30 years [23-43], 49.3% male). The median interval between SB-VCE and IUS was 3 days (0-25). Initially, the LS strongly correlated with TI-BWT (r\u2005=\u20050.647, P\u2005&amp;lt;\u2005.001), LI (r\u2005=\u20050.597, P\u2005&amp;lt;\u2005.001), and IBUS-SAS (r\u2005=\u20050.647, P\u2005&amp;lt;\u2005.001), but these correlations weakened over time (TI-BWT: r\u2005=\u20050.344, P\u2005=\u2005.002; LI: r\u2005=\u20050.471, P\u2005=\u2005.001; IBUS-SAS: r\u2005=\u20050.236, P\u2005=\u2005.122). Moderate agreement was found between ultrasonographic and endoscopic treatment responses (LS and TI-BWT: K\u2005=\u20050.51, P\u2005=\u2005.015; LS and LI: K\u2005=\u20050.44, P\u2005=\u2005.063), with fair agreement for remission (K\u2005=\u20050.27, P\u2005=\u2005.006). TI-BWT best cutoffs for mild (LS\u2005\u2265\u2005135) and moderate-to-severe (LS\u2005\u2265\u2005790) inflammation were 2.25 mm and 3.6 mm, respectively<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IUS measures are strongly correlated with VCE-inflammatory LS in active CD and may provide an assessment of endoscopic response and remission over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izae296","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T07:21:04Z","timestamp":1733210464000},"page":"2164-2172","source":"Crossref","is-referenced-by-count":5,"title":["Intestinal Ultrasound Measures are Strongly Correlated With Small Bowel Endoscopic Lewis Score in Active Crohn\u2019s 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Ashdod,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bella","family":"Ungar","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0490-0607","authenticated-orcid":false,"given":"Ido","family":"Veisman","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar","family":"Levy","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassem","family":"Sharif","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinhas","family":"Eidler","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Eliakim","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-0588","authenticated-orcid":false,"given":"Uri","family":"Kopylov","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-6803","authenticated-orcid":false,"given":"Dan","family":"Carter","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Sheba Medical Center Tel Hashomer , Ramat Gan,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel-Aviv University , Tel 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