{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:22:22Z","timestamp":1773231742568,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD17\/00014"],"award-info":[{"award-number":["CD17\/00014"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>MicroRNAs (miRNAs) play a key role in regulating gene expression in Crohn\u2019s disease (CD). Although several studies have identified miRNAs with biomarker potential, an exhaustive characterization of the miRNAome in CD is still lacking. We performed the largest miRNA profiling effort to date to analyze miRNA variability across intestinal tissues, disease activity status, and infliximab treatment in CD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We generated 119 transcriptomic profiles from the terminal ileum and left colon biopsies of 30 individuals (10 with active CD, 10 with quiescent CD, and 10 healthy controls). Half of the samples were cultured ex vivo with infliximab, and the remaining half with basal medium. Using variance analyses and linear mixed differential expression models, we explored the determinants of miRNAome variability in CD. We also generated infliximab response signatures to identify candidates and examine interactions between miRNAs and the coding transcriptome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Tissue location, and patient-specific effects, were the main factors in miRNA variability in CD, with some differentially expressed miRNAs involved in epithelial\u2013mesenchymal transition (miR-200s, miR-429). We identified 9 miRNAs with treatment-responsive behaviour, particularly to the terminal ileum of active CD cases. Although the changes observed in active CD cases suggest that many alterations are not offset by infliximab incubation, we described 13 miRNAs\u2013mRNA pairs with potential involvement in the anti-tumor necrosis factor (TNF) treatment, 7 of which have been already validated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A comprehensive miRNA profiling revealed significant intestinal tissue-specific variability and identified key alterations in the miRNA\u2013mRNA interactome that might be involved in therapeutic response to anti-TNF in CD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ibd\/izaf029","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:38:44Z","timestamp":1741700324000},"page":"1980-1993","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of the Regulatory Landscape in Crohn\u2019s Disease Reveals microRNA-Associated Alterations that Shape Anti-TNF Response"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-6410","authenticated-orcid":false,"given":"Luis","family":"Cervera-Seco","sequence":"first","affiliation":[{"name":"Integrative Genomics Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) , Derio, Basque Country ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-8154","authenticated-orcid":false,"given":"Montse","family":"Bald\u00e1n-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid , Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-4833","authenticated-orcid":false,"given":"Samuel","family":"Fern\u00e1ndez-Tom\u00e9","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Ciencia de los Alimentos, Facultad de Farmacia, Universidad Complutense de Madrid , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-8559","authenticated-orcid":false,"given":"Lorena","family":"Ortega Moreno","sequence":"additional","affiliation":[{"name":"\u00c1rea de Farmacolog\u00eda y Nutrici\u00f3n y Bromatolog\u00eda, Grupo de Investigaci\u00f3n de Alto Rendimiento en Fisiopatolog\u00eda del Sistema Digestivo URJC: NeuGut-URJC, Departamento Ciencias B\u00e1sicas de la Salud, Universidad Rey Juan Carlos , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-3908","authenticated-orcid":false,"given":"Juan J","family":"Lozano","sequence":"additional","affiliation":[{"name":"Bioinformatics Platform, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-612X","authenticated-orcid":false,"given":"Ana M","family":"Aransay","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid ,","place":["Spain"]},{"name":"Genome Analysis Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) , Derio, Basque Country ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid , Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS-Princesa), Universidad Aut\u00f3noma de Madrid , Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-6609","authenticated-orcid":false,"given":"Urko M","family":"Marigorta","sequence":"additional","affiliation":[{"name":"Integrative Genomics Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) , Derio, Basque Country ,","place":["Spain"]},{"name":"IKERBASQUE, Basque Foundation for Sciences , Bilbao ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"issue":"10080","key":"2025070803365085000_CIT0001","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"2025070803365085000_CIT0002","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3390\/cells8060535","article-title":"Molecular profiling of inflammatory bowel disease: is it ready for use in clinical decision-making","volume":"8","author":"Lee","year":"2019","journal-title":"Cells"},{"issue":"9","key":"2025070803365085000_CIT0003","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1093\/ecco-jcc\/jjab050","article-title":"Results of the Seventh Scientific Workshop of ECCO: precision medicine in IBD-disease outcome and response to therapy","volume":"15","author":"Verstockt","year":"2021","journal-title":"J Crohns Colitis."},{"key":"2025070803365085000_CIT0004","doi-asserted-by":"publisher","first-page":"17562848241251600","DOI":"10.1177\/17562848241251600","article-title":"Biomarkers in inflammatory bowel disease: a practical guide","volume":"17","author":"Clough","year":"2024","journal-title":"Therap Adv Gastroenterol"},{"key":"2025070803365085000_CIT0005","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-0716-2823-2_1","article-title":"miRNA biogenesis and regulation of diseases: an updated overview","volume":"2595","author":"Vishnoi","year":"2023","journal-title":"Methods Mol Biol"},{"issue":"5","key":"2025070803365085000_CIT0006","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.tig.2023.01.009","article-title":"miRNA biogenesis and inherited disorders: clinico-molecular insights","volume":"39","author":"Pelletier","year":"2023","journal-title":"Trends Genet"},{"issue":"6","key":"2025070803365085000_CIT0007","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1093\/ibd\/izac250","article-title":"Deep dive into MicroRNAs in inflammatory bowel disease","volume":"29","author":"Alfaifi","year":"2023","journal-title":"Inflamm Bowel Dis."},{"issue":"8","key":"2025070803365085000_CIT0008","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1053\/j.gastro.2019.02.023","article-title":"MicroRNA-31 reduces inflammatory signaling and promotes regeneration in colon epithelium, and delivery of mimics in microspheres reduces colitis in mice","volume":"156","author":"Tian","year":"2019","journal-title":"Gastroenterology."},{"issue":"8","key":"2025070803365085000_CIT0009","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10238-022-00935-9","article-title":"Updated immunomodulatory roles of gut flora and microRNAs in inflammatory bowel diseases","volume":"23","author":"Cheng","year":"2023","journal-title":"Clin Exp Med."},{"key":"2025070803365085000_CIT0010","doi-asserted-by":"publisher","first-page":"7565076","DOI":"10.1155\/2018\/7565076","article-title":"The role of autophagy and related microRNAs in inflammatory bowel disease","volume":"2018","author":"Wang","year":"2018","journal-title":"Gastroenterol Res Pract"},{"issue":"Supplement_2","key":"2025070803365085000_CIT0011","doi-asserted-by":"publisher","first-page":"ii30","DOI":"10.1093\/ecco-jcc\/jjac011","article-title":"Ustekinumab in Crohn\u2019s disease: new data for positioning in treatment algorithm","volume":"16","author":"D\u2019Amico","year":"2022","journal-title":"J Crohns Colitis."},{"issue":"10","key":"2025070803365085000_CIT0012","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/ueg2.12336","article-title":"Treat-to-target and sequencing therapies in Crohn\u2019s disease","volume":"10","author":"Garcia","year":"2022","journal-title":"United European Gastroenterol J"},{"issue":"10","key":"2025070803365085000_CIT0013","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1093\/ecco-jcc\/jjad086","article-title":"Defining biological remission in Crohn\u2019s disease: interest, challenges and future directions","volume":"17","author":"Pierre","year":"2023","journal-title":"J Crohns Colitis."},{"key":"2025070803365085000_CIT0014","doi-asserted-by":"publisher","first-page":"103329","DOI":"10.1016\/j.ebiom.2021.103329","article-title":"Evaluation of anti-TNF therapeutic response in patients with inflammatory bowel disease: current and novel biomarkers","volume":"66","author":"Cui","year":"2021","journal-title":"EBioMedicine"},{"issue":"9","key":"2025070803365085000_CIT0015","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1038\/ctg.2016.49","article-title":"Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease","volume":"7","author":"Heier","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"issue":"10","key":"2025070803365085000_CIT0016","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1093\/ibd\/izaa209","article-title":"Serum miRNAs are pharmacodynamic biomarkers associated with therapeutic response in pediatric inflammatory bowel disease","volume":"26","author":"Batra","year":"2020","journal-title":"Inflamm Bowel Dis."},{"issue":"21","key":"2025070803365085000_CIT0017","doi-asserted-by":"publisher","first-page":"15691","DOI":"10.3390\/ijms242115691","article-title":"Long non-coding RNA signatures in the ileum and colon of Crohn\u2019s disease patients and effect of anti-TNF-\u03b1 treatment on their modulation","volume":"24","author":"Baldan-Martin","year":"2023","journal-title":"Int J Mol Sci ."},{"issue":"3","key":"2025070803365085000_CIT0018","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"issue":"2","key":"2025070803365085000_CIT0019","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/bioinformatics\/btaa687","article-title":"Powerful differential expression analysis for repeated measures designs","volume":"37","author":"Hoffman","year":"2021","journal-title":"Bioinformatics."},{"issue":"D1","key":"2025070803365085000_CIT0020","doi-asserted-by":"publisher","first-page":"D142","DOI":"10.1093\/nar\/gkz1022","article-title":"miRPathDB 2.0: a novel release of the miRNA pathway dictionary database","volume":"48","author":"Kehl","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"2025070803365085000_CIT0021","doi-asserted-by":"publisher","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA\u2013target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"2025070803365085000_CIT0022","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"11","key":"2025070803365085000_CIT0023","doi-asserted-by":"publisher","first-page":"e7984","DOI":"10.1371\/journal.pone.0007984","article-title":"Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment","volume":"4","author":"Arijs","year":"2009","journal-title":"PLoS One."},{"issue":"11","key":"2025070803365085000_CIT0024","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1093\/ecco-jcc\/jjac059","article-title":"Network analysis of inflammatory bowel disease research: towards the interactome","volume":"16","author":"Fernandez","year":"2022","journal-title":"J Crohns Colitis."},{"issue":"1","key":"2025070803365085000_CIT0025","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13036-023-00333-z","article-title":"The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition","volume":"17","author":"Subbalakshmi","year":"2023","journal-title":"J Biol Eng"},{"issue":"3","key":"2025070803365085000_CIT0026","doi-asserted-by":"publisher","first-page":"e0173664","DOI":"10.1371\/journal.pone.0173664","article-title":"The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients","volume":"12","author":"Lewis","year":"2017","journal-title":"PLoS One."},{"issue":"1","key":"2025070803365085000_CIT0027","doi-asserted-by":"publisher","first-page":"102102","DOI":"10.1016\/j.omtn.2023.102102","article-title":"Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization","volume":"35","author":"Lin","year":"2024","journal-title":"Mol Ther Nucleic Acids."},{"issue":"1","key":"2025070803365085000_CIT0028","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2020.11.006","article-title":"Nrf2-induced miR-23a-27a-24-2 cluster modulates damage repair of intestinal mucosa by targeting the Bach1\/HO-1 axis in inflammatory bowel diseases","volume":"163","author":"Dun","year":"2021","journal-title":"Free Radic Biol Med."},{"issue":"11","key":"2025070803365085000_CIT0029","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.it.2022.09.003","article-title":"MicroRNA effects on gut homeostasis: therapeutic implications for inflammatory bowel disease","volume":"43","author":"Dhuppar","year":"2022","journal-title":"Trends Immunol."},{"issue":"1","key":"2025070803365085000_CIT0030","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/ibd.21691","article-title":"MicroRNAs in inflammatory bowel disease","volume":"18","author":"Pekow","year":"2012","journal-title":"Inflamm Bowel Dis."},{"issue":"1","key":"2025070803365085000_CIT0031","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/1756283X14547360","article-title":"The emerging role of miRNAs in inflammatory bowel disease: a review","volume":"8","author":"Chapman","year":"2015","journal-title":"Therap Adv Gastroenterol"},{"issue":"10","key":"2025070803365085000_CIT0032","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1111\/jcmm.12869","article-title":"Down-regulation of microRNAs of the miR-200 family and up-regulation of Snail and Slug in inflammatory bowel diseases \u2014 hallmark of epithelial\u2212mesenchymal transition","volume":"20","author":"Zidar","year":"2016","journal-title":"J Cell Mol Med."},{"issue":"3","key":"2025070803365085000_CIT0033","doi-asserted-by":"publisher","first-page":"219","DOI":"10.4161\/cbt.10.3.12548","article-title":"The role of the miR-200 family in epithelial-mesenchymal transition","volume":"10","author":"Mongroo","year":"2010","journal-title":"Cancer Biol Ther."},{"key":"2025070803365085000_CIT0034","doi-asserted-by":"publisher","first-page":"991346","DOI":"10.3389\/fimmu.2022.991346","article-title":"Global alteration of colonic microRNAome landscape associated with inflammatory bowel disease","volume":"13","author":"Boros","year":"2022","journal-title":"Front Immunol."},{"issue":"10","key":"2025070803365085000_CIT0035","doi-asserted-by":"publisher","first-page":"e13160","DOI":"10.1371\/journal.pone.0013160","article-title":"Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease","volume":"5","author":"Fasseu","year":"2010","journal-title":"PLoS One."},{"issue":"10","key":"2025070803365085000_CIT0036","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00011-016-0964-8","article-title":"NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells","volume":"65","author":"Negroni","year":"2016","journal-title":"Inflamm Res"},{"issue":"19","key":"2025070803365085000_CIT0037","doi-asserted-by":"publisher","first-page":"7846","DOI":"10.1158\/0008-5472.CAN-08-1942","article-title":"A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition","volume":"68","author":"Bracken","year":"2008","journal-title":"Cancer Res."},{"issue":"6","key":"2025070803365085000_CIT0038","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1093\/neuonc\/not011","article-title":"NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200","volume":"15","author":"Fu","year":"2013","journal-title":"Neuro Oncol"},{"issue":"1","key":"2025070803365085000_CIT0039","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/01.MIB.0000436954.70596.9b","article-title":"NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells","volume":"20","author":"Chuang","year":"2014","journal-title":"Inflamm Bowel Dis."},{"issue":"4","key":"2025070803365085000_CIT0040","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.dld.2016.12.022","article-title":"Altered mucosal expression of microRNAs in pediatric patients with inflammatory bowel disease","volume":"49","author":"B\u00e9res","year":"2017","journal-title":"Dig Liver Dis"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/advance-article-pdf\/doi\/10.1093\/ibd\/izaf029\/62375450\/izaf029.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/7\/1980\/62375450\/izaf029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/31\/7\/1980\/62375450\/izaf029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:36:58Z","timestamp":1751960218000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/31\/7\/1980\/8069452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,3,11]]},"published-print":{"date-parts":[[2025,7,7]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izaf029","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,3,11]]}}}