{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:55:59Z","timestamp":1778010959319,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007273","name":"Weill Cornell Medical College","doi-asserted-by":"publisher","award":["1-UL1-TR002384-01"],"award-info":[{"award-number":["1-UL1-TR002384-01"]}],"id":[{"id":"10.13039\/100007273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Ulcerative proctitis (UP) is a limited form of ulcerative colitis. While achieving endoscopic healing (EH) in ulcerative colitis improves long-term outcomes, the benefit of EH in UP is uncertain. This study aimed to assess the impact of EH on outcomes in UP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective study included adults with UP and \u22652 endoscopies, with active inflammation (Mayo endoscopic score [MES] 1-3) at index. EH was defined as MES 0-1 at follow-up procedure. The relationship of EH to inflammatory bowel disease (IBD)-related outcomes was assessed using univariate analysis and multivariable logistic regression assessed the effect of EH on IBD-related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 200 UP patients, 109 (54.5%) had EH at follow-up endoscopy at median 19 months (interquartile range: 7, 32). EH was associated with fewer IBD-related emergency department (ED) visits (EH: 8.3%, no EH: 21%, P\u2005=\u2005.01), hospitalizations (5.5% vs 18%), and GI visits (mean: 1.47\/year [SD: 1.40], vs 2.96\/year [2.52], P\u2005&amp;lt;\u2005.001). Patients with EH were less likely to have iron deficiency anemia (23% vs 41%, P\u2005=\u2005.007), Clostridioides difficile (0.9% vs 6.6%, P\u2005=\u2005.048), or initiate new biologic therapy after relapse (15% vs 33%, P\u2005=\u2005.034). Patients with EH had a greater time to clinical relapse (21 [24] vs 9 months [14]; P\u2005=\u2005.006) and lower odds of an IBD-related ED visit (OR: 0.32, 95% CI: 0.13, 0.73) or hospitalization (0.26 [0.09, 0.67]). Baseline presence of a cecal patch did not impact outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UP patients with EH had less IBD-related healthcare utilization, fewer IBD-related complications, and were less likely to escalate therapy after relapse than patients without EH. Using a treatment target of EH may therefore be desirable in UP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf044","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:04:21Z","timestamp":1743455061000},"page":"2725-2734","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Endoscopic Healing on Disease-Related Outcomes in Patients With Ulcerative Proctitis"],"prefix":"10.1093","volume":"31","author":[{"given":"Esther Y","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine,\u00a0Weill Cornell Medical College , New York , NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjile","family":"An","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medical College , New York, NY 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