{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:41:30Z","timestamp":1783726890845,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013958","name":"Telemark Hospital Trust","doi-asserted-by":"publisher","award":["3092.03"],"award-info":[{"award-number":["3092.03"]}],"id":[{"id":"10.13039\/501100013958","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Takeda Pharmaceuticals"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004914","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009471","name":"Dam Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"crossref"}]},{"name":"South-Eastern Health Authorities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with ulcerative colitis and Crohn\u2019s disease were recruited from the IBD in South-Eastern Norway III cohort study. Irritable bowel-like symptoms were assessed using the Rome IV criteria for patients in remission from IBD at 1- and 3-year follow-ups. Remission was defined objectively using the biochemical marker fecal calprotectin (FC)\u2005\u2264\u2005250 \u00b5g\/g, and comparisons to remission based on endoscopic indices were made at 1-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among patients with FC\u2005\u2264\u2005250 \u00b5g\/g, IBS prevalences were 21.9% (n\u2005=\u200562\/283) and 16.1% (n\u2005=\u200549\/304) at the 1- and 3-year follow-ups, respectively, which were higher than that in the Norwegian population (9.5%; P\u2005&amp;lt;\u2005.005). Of patients in endoscopic remission at 1-year follow-up, 19.2% (n\u2005=\u200543\/224) reported IBS-like symptoms, which was not significantly different from IBS prevalence for patients with FC\u2005\u2264\u2005250 \u00b5g\/g. Irritable bowel syndrome was independently associated with substantial fatigue (odds ratio: 3.05 [95% CI, 1.48-6.27]) and female sex (odds ratio: 2.67 [95% CI, 1.34-5.32]) at the 1-year follow-up. Patients with IBS reported significantly reduced health-related quality of life (HRQoL) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of IBS among patients in remission from IBD was approximately twice as common as that in the Norwegian population. Irritable bowel syndrome was independently associated with substantial fatigue, female sex, and reduced HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf047","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:34:10Z","timestamp":1740123250000},"page":"2704-2713","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of Irritable Bowel Syndrome Based on Rome IV Criteria in Patients in Biochemical and Endoscopic Remission From Newly Diagnosed Inflammatory Bowel Disease: One- and Three-Year Results (the IBSEN III Cohort)"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-753X","authenticated-orcid":false,"given":"Bjorn Christian","family":"Olsen","sequence":"first","affiliation":[{"name":"Telemark Hospital Trust, Department of Gastroenterology , Skien ,","place":["Norway"]},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo 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