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After adjusting for all confounders, each 1-year increase in PhenoAge acceleration was associated with a 6.9% increase in UC risk (HR\u2005=\u20051.069, 95% CI, 1.063-1.074) and an 8.5% increase in CD risk (HR\u2005=\u20051.085, 95% CI, 1.079-1.092). Participants who were biologically older showed a higher risk of UC (HR\u2005=\u20051.928, 95% CI, 1.799-2.067) and CD (HR\u2005=\u20052.557, 95% CI, 2.330-2.807) compared with their younger counterparts. Moreover, PhenoAge acceleration partially mediated the associations of alcohol consumption and cigarette smoking with UC and CD risk (11.2%-27.2%). We observed dose\u2013response associations between polygenic risk scores and both UC and CD. Compared with the bottom quintile, high-risk participants (top quintile) showed a 439.9% increase (HR\u2005=\u20052.229, 95% CI, 1.949-2.550) in UC risk and a 501.7% increase (HR\u2005=\u20056.017, 95% CI, 5.254-6.891) in CD risk. Notably, individuals with both high genetic risk and accelerated aging exhibited the greatest susceptibility (UC: HR\u2005=\u200511.569, 95% CI, 9.658-13.858; CD: HR\u2005=\u200512.018, 95% CI, 9.569-15.094).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PhenoAge acceleration may serve as a useful biomarker for identifying high-risk individuals, offering potential for integration into targeted prevention strategies and personalized treatment approaches for IBD.<\/jats:p>\n                    <jats:p>This study explores how accelerated biological aging (PhenoAge acceleration) and genetic susceptibility influence the risk of inflammatory bowel disease. Findings indicate that higher PhenoAge acceleration and genetic risk scores significantly increase the likelihood of developing ulcerative colitis and Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf106","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:48:06Z","timestamp":1745308086000},"page":"2986-2995","source":"Crossref","is-referenced-by-count":3,"title":["Biological Ageing and the Risk of Inflammatory Bowel Disease: Exploring the Role of Lifestyle and Genetic Susceptibility in a Nationwide Prospective Study"],"prefix":"10.1093","volume":"31","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China , Zhuhui, Hengyang 421002 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