{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T21:50:41Z","timestamp":1763761841420,"version":"3.45.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The Toronto IBD Global Endoscopic Reporting (TIGER) score is a single endoscopic scoring index for both patients with Crohn\u2019s disease (CD) and ulcerative colitis (UC). The goal of this study was to assess the direct relationship between TIGER scores and fecal calprotectin (FC) and C-reactive protein (CRP) after 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective 12-month study conducted in 1 tertiary IBD center. Baseline colonoscopy was performed. Moderate-to-severe mucosal involvement was defined as a TIGER score\u2005\u2265\u2005100, Simple Endoscopic Score for Crohn\u2019s disease\u2005\u2265\u20056, Mayo Endoscopic Score\u2005&amp;gt;\u20051. FC and CRP levels were documented at each visit. Baseline TIGER, SES-CD, and MES were utilized as a predictor for FC and CRP levels after 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population included 107 adults, 52 with CD and 55 with UC. A baseline TIGER score\u2005\u2265\u2005100 had a sensitivity and specificity of 0.964 and 0.941, respectively, at predicting a patient having an FC level\u2005\u2265\u2005800 \u03bcg\/g and\/or a CRP level\u2005\u2265\u20051.0\u00a0mg\/dL at 12-month follow-up. A baseline TIGER score\u2005\u2265\u2005100 was associated with increased likelihood of having FC\u2005&amp;gt;\u2005100 \u03bcg\/g (P\u2005&amp;lt;\u2005.001), and\u2005\u2265\u2005800 \u03bcg\/g (P\u2005&amp;lt;\u2005.001) after 12 months, despite receiving advanced therapy, after the 12-month follow-up period. Similar trends were observed with the SES-CD and MES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The TIGER score is a simple endoscopic score that can be used for both CD and UC that has been shown to have both construct validity with inflammatory marker and noninferiority to the current best-referenced endoscopic scores over a 12-month follow-up period. Future studies should begin incorporating TIGER as a measure of clinical response to interventions and therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf142","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T07:34:15Z","timestamp":1749972855000},"page":"3120-3131","source":"Crossref","is-referenced-by-count":0,"title":["Construct Validity of the Toronto IBD Global Endoscopic Reporting Score Compared to Inflammatory Biomarkers After 12-Month Follow-Up"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-4932","authenticated-orcid":false,"given":"Eran","family":"Zittan","sequence":"first","affiliation":[{"name":"The Abraham and Sonia Rochlin IBD Unit, Department of Gastroenterology and Liver Diseases, Emek Medical Center , Afula ,","place":["Israel"]},{"name":"The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology , Haifa ,","place":["Israel"]},{"name":"School of 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