{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:41:21Z","timestamp":1789674081949,"version":"4.0.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Small bowel capsule endoscopy is a valuable modality for evaluating small intestinal lesions in children with inflammatory bowel disease. However, its application for very early-onset inflammatory bowel disease remains insufficiently documented. This study investigated the feasibility and safety of small bowel capsule endoscopy for very early-onset inflammatory bowel disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort of patients with very early-onset inflammatory bowel disease who underwent small bowel capsule endoscopy at under 6 years of age between January 2013 and December 2022 at 7 Japanese pediatric centers was included. Their medical records were retrospectively reviewed for actual procedures, safety, and test results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty-two patients (21 with ulcerative colitis, 25 with Crohn\u2019s, 31 with inflammatory bowel disease\u2014unclassified, 4 with monogenic inflammatory bowel disease, and 1 with intestinal Beh\u00e7et\u2019s disease) were enrolled, and 104 small bowel capsule endoscopies (median age, 3.8 years; median body weight, 13.0\u00a0kg) were analyzed. All capsules were deployed endoscopically, mostly using delivery devices (95%). Gastrointestinal patency was assessed in 95% of procedures, most commonly using patency capsules (70%). Abnormal small bowel findings were observed in 42% of patients, with aphthae being the most common (34%), followed by ulcers (18%). No serious complications, including small intestinal retention and perforation, were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Small bowel capsule endoscopy for very early-onset inflammatory bowel disease is feasible with diagnostic utility, and it can be performed safely with appropriate evaluation using patency capsules.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf144","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:01:39Z","timestamp":1750838499000},"page":"3279-3285","source":"Crossref","is-referenced-by-count":6,"title":["Feasibility and Safety of Small Bowel Capsule Endoscopy in Very Early-Onset Inflammatory Bowel Disease: A Multi-Institutional Study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-1329","authenticated-orcid":false,"given":"Shin-ichiro","family":"Hagiwara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women\u2019s and Children\u2019s Hospital , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-0420","authenticated-orcid":false,"given":"Hirotaka","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Center for Pediatric Inflammatory Bowel Disease, National Center for Child Health and Development , Tokyo,","place":["Japan"]},{"name":"Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-7111","authenticated-orcid":false,"given":"Ryusuke","family":"Nambu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Saitama Children\u2019s Medical Center , Saitama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-4305","authenticated-orcid":false,"given":"Keisuke","family":"Jimbo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Juntendo University Faculty of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-7085","authenticated-orcid":false,"given":"Emiri","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Osaka Medical and Pharmaceutical University , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2515-3508","authenticated-orcid":false,"given":"Takuya","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gunma University Graduate School of Medicine , Maebashi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-0937","authenticated-orcid":false,"given":"Fumihiko","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Gastroenterology, Miyagi Children\u2019s Hospital , Sendai,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-8195","authenticated-orcid":false,"given":"Itaru","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Saitama Children\u2019s Medical Center , Saitama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-7359","authenticated-orcid":false,"given":"Takashi","family":"Ishige","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gunma University Graduate School of Medicine , Maebashi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4708-8049","authenticated-orcid":false,"given":"Takahiro","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Juntendo University Faculty of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-4640","authenticated-orcid":false,"given":"Katsuhiro","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Center for Pediatric Inflammatory Bowel Disease, National Center for Child Health and 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