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Birgitta och G\u00f6ran Karlssons Stiftelse"},{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001424","name":"ALF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Avtal om L\u00e4karutbildning och Forskning"},{"DOI":"10.13039\/501100004973","name":"Barndiabetesfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004973","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Child Diabetes Foundation"},{"DOI":"10.13039\/501100001861","name":"Swedish Council for Working Life and Social Research","doi-asserted-by":"publisher","award":["FAS2004-1775"],"award-info":[{"award-number":["FAS2004-1775"]}],"id":[{"id":"10.13039\/501100001861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["K2005-72X-11242-11A"],"award-info":[{"award-number":["K2005-72X-11242-11A"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["K2008-69X-20826-01-4"],"award-info":[{"award-number":["K2008-69X-20826-01-4"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u00d6stg\u00f6ta Brandstodsbolag"},{"DOI":"10.13039\/100010805","name":"Medical Research Council of Southeast Sweden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JDRF Wallenberg Foundation","award":["K 98-99D-12813-01A"],"award-info":[{"award-number":["K 98-99D-12813-01A"]}]},{"name":"Region \u00d6sterg\u00f6tland and Link\u00f6ping University"},{"DOI":"10.13039\/100031862","name":"Joanna Cocozza Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Childhood overweight and obesity are emerging global health issues with potential implications for immune function. We aimed to investigate childhood body mass index (BMI) as a risk factor for later inflammatory bowel disease (IBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ABIS (Sweden) and MoBa (Norway) are population-based cohorts following participants prospectively from birth (1997\u20132009) until 2023. We retrieved anthropometric data at birth, 1, 3, and 7\u20138\u2009years to examine the association of age-specific standardized BMI percentiles and categories (underweight, normal [reference), overweight, obesity) with later IBD. We also analyzed IBD risk according to BMI trajectories across ages. IBD diagnosis was identified in national health registries. Cohort-specific hazard ratios (aHRs) were adjusted for sociodemographics, parental BMI, IBD, and smoking and pooled using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, among 54\u200a890 children with 803\u200a444 person-years of follow-up, we identified 246 IBD events. Eight-year-olds living with obesity had a 5-fold increased risk of ulcerative colitis (pooled aHR\u2009=\u20095.10; 95% CI\u2009, 1.51\u201317.27), but not a significantly increased risk of Crohn\u2019s disease (pooled aHR\u2009=\u20091.38; 95% CI\u2009, 0.24\u20137.98) and IBD overall (pooled aHR\u2009=\u20091.89; 95% CI\u2009, 0.71\u20135.04). Children with overweight or obesity at age 3 had no increased risk of IBD compared to normal-weight children (pooled aHR\u2009=\u20091.15, 95% CI\u2009, 0.74\u20131.77; and 1.05, 95% CI\u2009, 0.43\u20132.58, respectively). Early-life BMI trajectories were not consistently associated with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this Scandinavian birth cohort, 7\u20138 year-old children with obesity had an increased risk of developing ulcerative colitis later in life. Given the high prevalence of childhood obesity, this observation should be corroborated and possible mechanisms behind the association clarified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf167","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:09:09Z","timestamp":1752502149000},"page":"3327-3336","source":"Crossref","is-referenced-by-count":4,"title":["Early-Life Body Mass Index and Inflammatory Bowel Disease Risk: A Scandinavian Birth Cohort Study"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-2347","authenticated-orcid":false,"given":"Tereza","family":"Lerchova","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Biomedical and Clinical Sciences, Link\u00f6ping University , Link\u00f6ping,","place":["Sweden"]},{"name":"Crown Princess Victoria Children\u2019s Hospital , Link\u00f6ping,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"M\u00e5rild","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Imberg","sequence":"additional","affiliation":[{"name":"Statistiska Konsultgruppen Sweden , Gothenburg,","place":["Sweden"]},{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Andersson","sequence":"additional","affiliation":[{"name":"Bioinformatics and Data Centre, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketil","family":"St\u00f8rdal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Research, Faculty of Medicine, University of Oslo , Oslo,","place":["Norway"]},{"name":"Department of Pediatrics and Adolescent Medicine, Oslo University Hospital , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"M\u00e5rild","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]},{"name":"Department of Pediatrics, Queen 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