{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:07:03Z","timestamp":1790201223174,"version":"4.1.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K23DK136977-01A1"],"award-info":[{"award-number":["1K23DK136977-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is growing recognition that inflammatory bowel disease (IBD), including Crohn\u2019s disease (CD) and ulcerative colitis (UC), is preceded by a prolonged preclinical phase marked by subtle but measurable changes in the immune system, gut microbiome, and epithelial barrier function. These early alterations, often detectable years before diagnosis, offer a window of opportunity for disease interception. In this review, we examine the current evidence for environmental, microbial, and molecular factors that may contribute to the initiation of IBD, with a particular focus on modifiable risk pathways. We discuss preventive strategies across different levels of risk\u2014from lifestyle and environmental interventions in the general population to more targeted approaches in individuals with familial predisposition, such as first-degree relatives. We also highlight recent findings on emerging biomarkers, including anti-flagellin antibodies, anti-GM-CSF autoantibodies, glycome, and integrin-targeted immune responses, that could guide precision prevention efforts. While most evidence to date has focused on CD, we also review preclinical insights relevant to UC. As the field moves toward earlier identification of at-risk individuals, the concept of \u201cprecision prevention\u201d\u2014matching interventions to individual risk and biology\u2014may ultimately shift the paradigm of IBD care from treatment to prevention.<\/jats:p>","DOI":"10.1093\/ibd\/izaf168","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:09:09Z","timestamp":1752502149000},"page":"S51-S60","source":"Crossref","is-referenced-by-count":6,"title":["Identifying Potential Targets for the Interception of Inflammatory Bowel Disease: Toward Precision Prevention"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0344-0047","authenticated-orcid":false,"given":"Sun-Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Termerty Faculty of Medicine, University of Toronto , Toronto, ON,","place":["Canada"]},{"name":"Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenebaum Research Institute, Mount Sinai Hospital , Toronto, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital , Boston, MA,","place":["United States"]},{"name":"Clinical and Translation Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Frederic","family":"Colombel","sequence":"additional","affiliation":[{"name":"Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8687-3758","authenticated-orcid":false,"given":"Ryan","family":"Ungaro","sequence":"additional","affiliation":[{"name":"Dr Henry D. 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