{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:39:00Z","timestamp":1781278740580,"version":"3.54.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dutch MDL Fonds","award":["ZP 21-13"],"award-info":[{"award-number":["ZP 21-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) may negatively affect health-related physical fitness. However, the development of interventions to improve health-related physical fitness and thereby disease outcomes is hindered by insufficient evidence. This study compared health-related physical fitness between patients with IBD and healthy control subjects, examined associations with disease and treatment characteristics, and explored patients\u2019 perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, 105 patients with IBD and 102 age- and sex-matched healthy control subjects performed validated tests for body fat (4-site skinfold thickness), cardiorespiratory fitness (steep ramp test), muscular strength (steep ramp test, 60-second sit-to-stand test, hand-held dynamometry), muscular endurance (isokinetic dynamometry), and flexibility (sit-and-reach test). Data on disease and treatment characteristics, fatigue, physical activity, and patients\u2019 perspectives were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with IBD had higher body fat (29.5% vs 26.9%; P\u2009=\u2009.012), lower steep ramp test performance (peak work rate 4.2\u2009W\/kg vs 4.8\u2009W\/kg; P\u2009&amp;lt;\u2009.001), fewer sit-to-stand repetitions (42 vs 47; P\u2009=\u2009.002), and reduced hamstring strength (3.0\u2009N\/kg vs 3.2\u2009N\/kg; P\u2009=\u2009.011) compared with healthy control subjects. This was associated with higher age, female sex, higher body mass index, fatigue, arthritis, and multiple biologicals used. Most patients considered physical fitness important and beneficial for their symptoms, and the majority expressed interest in professional support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with IBD have higher body fat and reduced cardiorespiratory fitness and muscular strength compared with healthy control subjects. Especially, patients with a higher age, female sex, higher body mass index, fatigue, arthritis, or multiple biologicals used are at risk for such impairments and may benefit from physical exercise interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf169","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T13:13:19Z","timestamp":1752585199000},"page":"3337-3355","source":"Crossref","is-referenced-by-count":2,"title":["Health-Related Physical Fitness in Patients With Inflammatory Bowel Disease vs Healthy Control Subjects"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-9959","authenticated-orcid":false,"given":"Karlijn","family":"Demers","sequence":"first","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Center+ , 6229 HX Maastricht,","place":["the Netherlands"]},{"name":"Department of Gastroenterology-Hepatology, Maastricht University Medical Center+ , 6229 HX Maastricht,","place":["the Netherlands"]},{"name":"Department of Surgery, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , PO Box 616, 6200 MD Maastricht,","place":["the Netherlands"]},{"name":"Department of Gastroenterology-Hepatology, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , Maastricht, PO Box 616, 6200 MD,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noortje","family":"van den Bergh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology-Hepatology, Maastricht University Medical Center+ , 6229 HX Maastricht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C","family":"Bongers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , PO Box 616, 6200 MD Maastricht,","place":["the Netherlands"]},{"name":"Department of Nutrition and Movement Sciences, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , PO Box 616, 6200 MD Maastricht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-729X","authenticated-orcid":false,"given":"Sander M J","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center , PO Box 5800, 6202 AZ Maastricht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-0381","authenticated-orcid":false,"given":"Zlatan","family":"Mujagic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology-Hepatology, Maastricht University Medical Center+ , 6229 HX Maastricht,","place":["the Netherlands"]},{"name":"Department of Gastroenterology-Hepatology, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , Maastricht, PO Box 616, 6200 MD,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy M A E","family":"Jonkers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology-Hepatology, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , Maastricht, PO Box 616, 6200 MD,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J","family":"Pierik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology-Hepatology, Maastricht University Medical Center+ , 6229 HX Maastricht,","place":["the Netherlands"]},{"name":"Department of Gastroenterology-Hepatology, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , Maastricht, PO Box 616, 6200 MD,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurents P S","family":"Stassen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maastricht University Medical Center+ , 6229 HX Maastricht,","place":["the Netherlands"]},{"name":"Department of Surgery, Institute of Nutrition and Translational Research in Metabolism, Maastricht University , PO Box 616, 6200 MD Maastricht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"2025120914525178400_izaf169-B1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.crohns.2013.01.010","article-title":"The burden of inflammatory bowel disease in Europe","volume":"7","author":"Burisch","year":"2013","journal-title":"J Crohns 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