{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:15:51Z","timestamp":1792080951220,"version":"4.4.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Proyectos de investigaci\u00f3n en salud","award":["PI22\/01157"],"award-info":[{"award-number":["PI22\/01157"]}]},{"name":"Proyectos de investigaci\u00f3n en salud","award":["CIBEREHD CB06\/04\/0071"],"award-info":[{"award-number":["CIBEREHD CB06\/04\/0071"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIPROM2021\/044"],"award-info":[{"award-number":["CIPROM2021\/044"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD), which encompasses ulcerative colitis (UC) and Crohn\u2019s disease (CD), is a chronic condition characterized by recurrent intestinal inflammation and complications. Despite extensive research on bacterial dysbiosis in IBD, the role of the gut mycobiome remains largely unexplored, particularly in surgical tissue specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we performed a comprehensive analysis of the intestinal fungal communities in surgical resections obtained from 20 patients with UC and 30 patients with CD, with non-IBD resections serving as controls. Fungal DNA was extracted and the internal transcribed spacer (ITS) region was amplified and sequenced using high-throughput Illumina technology. RNA from surgical resections from both non-IBD and IBD patients was obtained and the expression of pro-inflammatory and profibrotic genes was analyzed by real-time quantitative polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bioinformatic analysis revealed modest changes in fungal diversity in UC resections compared with those from controls. However, CD specimens exhibited significant alterations in mycobiome composition, including an increased abundance of Malassezia, specifically Malassezia globose, alongside a reduction in Yarrowia lipolytica. Moreover, stratification of CD into complicated phenotypes (B2 stricturing vs B3 penetrating) identified distinct fungal signatures capable of discriminating between these clinical phenotypes. Correlation analyses revealed a direct association between the mycobiome and intestinal inflammation and fibrosis, in parallel with several interactions between fungal and bacterial species, further reporting interkingdom interactions between both microbial communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results underscore the potential of fungal biomarkers in elucidating IBD pathogenesis and its associated complications, which opens up promising avenues for targeted therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf178","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:31:06Z","timestamp":1753183866000},"page":"3256-3270","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of Intestinal Mycobiome in Surgical Resections from Inflammatory Bowel Disease Patients: A Deeper Analysis in Complicated Crohn\u2019s Disease Phenotypes"],"prefix":"10.1093","volume":"31","author":[{"given":"Andrea","family":"Cejudo-Garc\u00e9s","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Valencia , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Carda-Di\u00e9guez","sequence":"additional","affiliation":[{"name":"Genomics and Health Department, FISABIO Foundation , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Navarro-Vicente","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda General y del Aparato Digestivo, Hospital de Manises , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Calatayud","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Valencia , Valencia,","place":["Spain"]},{"name":"CIBEREHD (Centro de Investigaciones en Red Enfermedad Hep\u00e1tica y Digestiva) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Ortiz-Masi\u00e1","sequence":"additional","affiliation":[{"name":"CIBEREHD (Centro de Investigaciones en Red Enfermedad Hep\u00e1tica y Digestiva) , Madrid,","place":["Spain"]},{"name":"Departamento de Medicina, Facultad de Medicina, Universidad de Valencia , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lex","family":"Mira","sequence":"additional","affiliation":[{"name":"Genomics and Health Department, FISABIO Foundation , Valencia,","place":["Spain"]},{"name":"CIBER Center for Epidemiology and Public Health , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Barrachina","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Valencia , Valencia,","place":["Spain"]},{"name":"CIBEREHD (Centro de Investigaciones en Red Enfermedad Hep\u00e1tica y Digestiva) , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-4908","authenticated-orcid":false,"given":"Jes\u00fas","family":"Cos\u00edn-Roger","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de Valencia , Valencia,","place":["Spain"]},{"name":"CIBEREHD (Centro de Investigaciones en Red Enfermedad Hep\u00e1tica y Digestiva) , 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