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Studies comparing fecal, gut mucosal, and salivary microbiomes are rare, and questions remain regarding the interaction of these compartments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case-control study, 16S rRNA gene amplicon sequencing was performed on samples from stool, intestinal mucosa, and saliva of 120 patients with IBD. Patients with signs of non-IBD colonic inflammation (N\u2009=\u200928) and healthy subjects (N\u2009=\u200967) served as controls. A total of 480 16S profiles were analyzed. The results were evaluated with multiple clinical and pathological parameters and potential confounders were considered. The study aimed to find microbial biomarkers specific to IBD and signatures of intestinal barrier dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fecal \u03b1-diversity of IBD patients was reduced and Pseudomonas species was significantly increased in the mucosa of IBD patients (Pseudomonas-positive mucosa [PSM positive], P value &amp;lt; .001, Mann-Whitney U test). Comparison of matched stool and mucosa samples showed high abundance of Pseudomonas species in gut mucosa but not in fecal samples, especially in CD patients. Interestingly, in PSM positive, Paracoccus species, Bacteroides species, and Streptococcus species were more abundant. Importantly, the results were independent of disease severity, histopathology, medication, and other metadata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The opportunistic pathogenic bacterium Pseudomonas species is more prevalent in the gut mucosa of patients with IBD. This indicates a disruption of the gut barrier with increasing mucosal colonization or invasion of the bacteria. The finding is independent of clinical metadata and confounders and occurs in new-onset IBD but not in non-IBD intestinal inflammation, which suggests disease specificity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ibd\/izaf185","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:50Z","timestamp":1753876310000},"page":"339-349","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Different Sites of Microbiota Shows Increased\n                    <i>Pseudomonas<\/i>\n                    Species in the Gut Mucosa in Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-799X","authenticated-orcid":false,"given":"David","family":"Schult-Hannemann","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Clinical Department for Internal Medicine II, Technical University Munich (TUM) School of Medicine and Health, University Medical 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