{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:47:24Z","timestamp":1777949244622,"version":"3.51.4"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Lay Summary<\/jats:title>\n                  <jats:p>Our case shows that a diverting ileostomy may be a viable bowel-sparing surgical option instead of colectomy during a refractory ulcerative colitis (UC) flare from checkpoint-inhibitor therapy, allowing time for checkpoint-inhibitor washout and optimization of biologic therapy prior to ileostomy reversal.<\/jats:p>","DOI":"10.1093\/ibd\/izaf187","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:53:44Z","timestamp":1753271624000},"page":"1009-1010","source":"Crossref","is-referenced-by-count":1,"title":["Diverting Loop Ileostomy as an Alternative to Emergent Colectomy in Acute Severe Ulcerative Colitis Flare following Checkpoint-Inhibitor Therapy"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-0020","authenticated-orcid":false,"given":"Ethan X","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, Victoria,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinna","family":"An","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Eastern Health , Box Hill, Victoria,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-3589","authenticated-orcid":false,"given":"Mayur","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Northern Health , Epping, Victoria,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Parkville, Victoria,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"2026050317364342100_izaf187-B1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/apt.16217","article-title":"Systematic review with meta-analysis: safety and tolerability of immune checkpoint inhibitors in patients with pre-existing inflammatory bowel diseases","volume":"53","author":"Meserve","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"2026050317364342100_izaf187-B2","doi-asserted-by":"publisher","first-page":"e003277","DOI":"10.1136\/jitc-2021-003277","article-title":"Efficacy and safety of vedolizumab and infliximab treatment for immune-mediated diarrhea and colitis in patients with cancer: a two-center observational study","volume":"9","author":"Zou","year":"2021","journal-title":"J Immunother Cancer"},{"key":"2026050317364342100_izaf187-B3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1097\/DCR.0000000000000985","article-title":"Rescue diverting loop ileostomy: an alternative to emergent colectomy in the setting of severe acute refractory IBD-Colitis","volume":"61","author":"Russell","year":"2018","journal-title":"Dis Colon Rectum"},{"key":"2026050317364342100_izaf187-B4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/CJI.0000000000000309","article-title":"Complete recovery of immune checkpoint inhibitor-induced colitis by diverting loop ileostomy","volume":"43","author":"Horisberger","year":"2020","journal-title":"J Immunother"}],"container-title":["Inflammatory Bowel Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/32\/5\/1009\/64326575\/izaf187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article-pdf\/32\/5\/1009\/64326575\/izaf187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:36:47Z","timestamp":1777844207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ibdjournal\/article\/32\/5\/1009\/8258730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":4,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,19]]},"published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ibd\/izaf187","relation":{},"ISSN":["1078-0998","1536-4844"],"issn-type":[{"value":"1078-0998","type":"print"},{"value":"1536-4844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,9,19]]}}}